Advancements in Antibacterial Therapy: Feature Papers
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 557 - 557
Опубликована: Март 1, 2025
Antimicrobial
resistance
(AMR)
is
a
growing
global
health
crisis
that
threatens
the
efficacy
of
antibiotics
and
modern
medical
interventions.
The
emergence
multidrug-resistant
(MDR)
pathogens,
exacerbated
by
misuse
in
healthcare
agriculture,
underscores
urgent
need
for
innovative
solutions.
(1)
Background:
AMR
arises
from
complex
interactions
between
human,
animal,
environmental
health,
further
aggravated
overuse
inadequate
regulation
antibiotics.
Conventional
treatments
are
increasingly
ineffective,
necessitating
alternative
strategies.
Emerging
approaches,
including
bacteriophage
therapy,
antimicrobial
peptides
(AMPs),
nanotechnology,
microbial
extracellular
vesicles
(EVs),
CRISPR-based
antimicrobials,
provide
novel
mechanisms
complement
traditional
combating
resistant
pathogens.
(2)
Methods:
This
review
critically
analyzes
advanced
antibacterial
strategies
conjunction
with
systemic
reforms
such
as
stewardship
programs,
One
Health
framework,
surveillance
tools.
These
methods
can
enhance
detection,
guide
interventions,
promote
sustainable
practices.
Additionally,
economic,
logistical,
regulatory
challenges
impeding
their
implementation
evaluated.
(3)
Results:
technologies,
CRISPR
exhibit
promising
potential
targeting
mechanisms.
However,
disparities
resource
distribution
barriers
hinder
widespread
adoption.
Public–private
partnerships
agriculture
practices
critical
to
overcoming
these
obstacles.
(4)
Conclusions:
A
holistic
integrated
approach
essential
mitigating
impact
AMR.
By
aligning
therapeutic
policies,
fostering
interdisciplinary
collaboration,
ensuring
equitable
distribution,
we
develop
response
this
21st-century
challenge.
Язык: Английский
Coumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents
Molecular Diversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Molecular dynamics simulation-driven focused virtual screening and experimental validation of Fisetin as an inhibitor of Helicobacter pylori HtrA protease
Molecular Diversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Язык: Английский
Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities
BioEssays,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
The
public
health
issue
of
bacterial
multi-resistance
to
antibiotics
has
gained
awareness
among
the
public,
researchers,
and
pharmaceutical
sector.
Nevertheless,
spread
antimicrobial
resistance
been
considerably
aggravated
by
human
activities,
climate
change,
subsequent
increased
release
antibiotics,
drug-resistant
bacteria,
antibiotic
genes
in
environment.
extensive
use
for
medical
veterinary
purposes
not
only
induced
increasing
but
also
other
problems,
including
negative
effects
on
patient's
microbiome.
Preventive
strategies,
new
treatment
modalities,
surveillance
are
progressively
set
up.
A
comprehensive
approach
is,
however,
lacking
urgently
tackling
this
adverse
situation.
To
address
challenge,
we
discussed
here
main
causes
driving
pollution
environment
factors
favorable
emergence
drug
resistance.
We
next
propose
some
key
priorities
research,
prevention,
surveillance,
education
supervise
an
effective
clinical
sustainable
response.
Язык: Английский