Antifungal and Antioxidant Activity of Thiourea Derivatives Against Nosocomial Candida auris Strains Isolated in Romania DOI Creative Commons
Marina Ionela Nedea, Carmellina Daniela Bădiceanu, Irina Gheorghe-Barbu

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1675 - 1675

Опубликована: Апрель 9, 2025

Nosocomial fungal infections caused by Candida auris pose a threat to public health due their increased resistance common antifungal drugs. Four thiourea derivatives of 2-thiophenecarboxylic acid were evaluated for and antioxidant activity. The activity the compounds was tested against strains C. isolated from hospital in Romania. With notable inhibitory effect on biofilm growth microbial adherence, ortho-methylated derivative (SB2) showed highest Furthermore, emphasizing impact structural factors electron-donating capacity these compounds, assays (DPPH, FRAP, TEAC CUPRAC) identified SB2 compound as having antihemolytic effects. low cytotoxicity validated hemocompatibility makes options treatment. results show that action is greatly influenced modifications, especially position methyl group aromatic ring. possible clinical uses molecules drugs treatment multidrug-resistant needs further investigation.

Язык: Английский

Antifungal and Antioxidant Activity of Thiourea Derivatives Against Nosocomial Candida auris Strains Isolated in Romania DOI Creative Commons
Marina Ionela Nedea, Carmellina Daniela Bădiceanu, Irina Gheorghe-Barbu

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1675 - 1675

Опубликована: Апрель 9, 2025

Nosocomial fungal infections caused by Candida auris pose a threat to public health due their increased resistance common antifungal drugs. Four thiourea derivatives of 2-thiophenecarboxylic acid were evaluated for and antioxidant activity. The activity the compounds was tested against strains C. isolated from hospital in Romania. With notable inhibitory effect on biofilm growth microbial adherence, ortho-methylated derivative (SB2) showed highest Furthermore, emphasizing impact structural factors electron-donating capacity these compounds, assays (DPPH, FRAP, TEAC CUPRAC) identified SB2 compound as having antihemolytic effects. low cytotoxicity validated hemocompatibility makes options treatment. results show that action is greatly influenced modifications, especially position methyl group aromatic ring. possible clinical uses molecules drugs treatment multidrug-resistant needs further investigation.

Язык: Английский

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