Optimization of LCD-Based 3D Printing for the Development of Clotrimazole-Coated Microneedle Systems
Materials,
Год журнала:
2025,
Номер
18(7), С. 1580 - 1580
Опубликована: Март 31, 2025
Fungal
infections
pose
a
significant
global
health
problem,
affecting
20–25%
of
the
population
and
contributing
to
over
3.75
million
deaths
annually.
Clotrimazole
(CLO)
is
widely
used
topical
antifungal
drug,
but
its
efficacy
limited
by
poor
penetration
through
stratum
corneum.
Microneedle
(MN)
systems,
composed
micron-scale
structures
arranged
on
patch,
offer
promising
strategy
overcome
outermost
skin
barrier
enhance
drug
into
deeper
layers.
However,
optimizing
MN
design,
particularly
in
terms
size,
shape,
fabrication
technology,
essential
for
efficient
delivery.
This
study
aimed
develop
CLO-coated
systems
using
an
Liquid
Crystal
Display
(LCD)-based
3D
printing
technique
thin-film
dip-coating
method.
A
comprehensive
optimization
parameters,
including
anti-aliasing,
layer
thickness,
curing
time,
angle,
was
conducted
ensure
desired
mechanical
properties.
The
optimized
MNs
were
coated
with
either
suspension
or
ethanol-based
CLO-hydrogels,
ethanol
hydrogel
demonstrating
superior
characteristics.
Additionally,
investigated
how
microneedle
geometry
coating
formulation
influenced
release.
Antifungal
activity
against
reference
clinical
origin
Candida
albicans
strains
varied
significantly
depending
formulation.
Finally,
acute
toxicity
test
confirmed
no
toxic
effects
Aliivibrio
fischeri,
indicating
potential
biocompatibility
safety
developed
MN-based
delivery
system.
Язык: Английский
Enhancing melanoma therapy with hydrogel microneedles
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
Язык: Английский