Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113903 - 113903

Опубликована: Окт. 22, 2022

Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the most serious adverse reaction after DOX treatment, which eventually leads cardiomyopathy and greatly limits clinical application DOX. DOX-induced not result single mechanistic action, multiple mechanisms have been discovered demonstrated experimentally, such oxidative stress, inflammation, mitochondrial damage, calcium homeostasis disorder, ferroptosis, autophagy apoptosis. Dexrazoxane (DEX) only protective approved by FDA for treatment cardiomyopathy, but its still has some limitations. Therefore, we need find other effective drugs soon possible. In this paper, that effectively improve in recent years are mainly described from aspects natural drugs, endogenous substances, new dosage forms, herbal medicines, chemical modification marketed drugs. The aim present study evaluate effects these on anticancer curative effects, so provide reference value future.

Язык: Английский

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Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(3), С. 399 - 422

Опубликована: Март 3, 2024

Introduction Doxorubicin (DOX) emerges as a cornerstone in the arsenal of potent chemotherapeutic agents. Yet, clinical deployment DOX is tarnished by its proclivity to induce severe cardiotoxic effects, culminating heart failure and other consequential morbidities. In response, panoply strategies has undergone rigorous exploration over recent decades, all aimed at attenuating DOX's impact. The advent encapsulating within lipidic or polymeric nanocarriers yielded dual triumph, augmenting therapeutic efficacy while mitigating deleterious side effects.

Язык: Английский

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A hyaluronic acid modified cuprous metal-organic complex for reversing multidrug resistance via redox dyshomeostasis

Carbohydrate Polymers, Год журнала: 2023, Номер 311, С. 120762 - 120762

Опубликована: Март 5, 2023

Язык: Английский

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Doxorubicin-mediated cardiac dysfunction: Revisiting molecular interactions, pharmacological compounds and (nano)theranostic platforms

Environmental Research, Год журнала: 2023, Номер 234, С. 116504 - 116504

Опубликована: Июнь 24, 2023

Язык: Английский

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Phytosynthesis of zinc oxide nanoparticles for enhanced antioxidant, antibacterial, and photocatalytic properties: A greener approach to environmental sustainability

Environmental Research, Год журнала: 2024, Номер 251, С. 118770 - 118770

Опубликована: Март 20, 2024

Язык: Английский

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Box–Behnken Design: Optimization of Proanthocyanidin-Loaded Transferosomes as an Effective Therapeutic Approach for Osteoarthritis

Nanomaterials, Год журнала: 2022, Номер 12(17), С. 2954 - 2954

Опубликована: Авг. 26, 2022

Transferosomes are one of the vesicular carriers that have received extensive research and attention recently because their capacity to get beyond barriers posed by stratum corneum penetration. The intent current study is optimize evaluate proanthocyanidin (PAC) containing transferosomal transdermal gels. PAC-containing transferosomes were prepared using film hydration method then loaded into a 4% methylcellulose gel. A 23 Box-Behnken design was used PAC-loaded gel, where effects phospholipid 90 G (X1), Tween 80 (X2), sonication time (X3) evaluated. formulation factors, such as drug entrapment efficiency percentage (PEE) in vitro release, characterized. PEE 78.29 ± 1.43% release at 6 h 24.2 1.25% obtained. optimized transferosomal-loaded (OTP) penetrated porcine skin an excellent rate (0.123 0.0067 mg/cm2/h). Stability tests conducted for OTP predict various temperature conditions on physical appearance, content, periods 15, 30, 45 days. Finally, this system PAC delivery may be suitable alternative conventional treatment osteoarthritis.

Язык: Английский

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Diosmin-loaded chitosan nanoparticles mitigate doxorubicin-evoked cardiotoxicity in rats by featuring oxidative imbalance mechanism, NF-κB, and Bcl-2/Bax pathways

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140991 - 140991

Опубликована: Фев. 1, 2025

Язык: Английский

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ULK1 Mediated Autophagy-Promoting Effects of Rutin-Loaded Chitosan Nanoparticles Contribute to the Activation of NF-κB Signaling Besides Inhibiting EMT in Hep3B Hepatoma Cells

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4465 - 4493

Опубликована: Май 1, 2024

Background: Liver cancer remains to be one of the leading causes worldwide. The treatment options face several challenges and nanomaterials have proven improve bioavailability drug candidates their applications in nanomedicine. Specifically, chitosan nanoparticles (CNPs) are extremely biodegradable, pose enhanced biocompatibility considered safe for use medicine. Methods: CNPs were synthesized by ionic gelation, loaded with rutin (rCNPs) characterized ultraviolet–visible spectroscopy (UV-Vis), Fourier-transform infrared (FTIR), dynamic light scattering (DLS) transmission electron microscopy (TEM). rCNPs tested cytotoxic effects on human hepatoma Hep3B cells, experiments conducted determine mechanism such effects. Further, was L929 fibroblasts, hemocompatibility determined. Results: Initially, UV–vis FTIR analyses indicated possible loading rCNPs. load quantitatively measured using Ultra-Performance Liquid Chromatography (UPLC) concentration 88 μg/mL 0.22 micron filtered capacity (LC%) observed 13.29 ± 0.68%, encapsulation efficiency (EE%) 19.55 1.01%. release pH-responsive as 88.58% released after 24 hrs at lysosomal pH 5.5, whereas 91.44% physiological 7.4 102 hrs. prominent samples 5 mg/mL precursor. particle size this 144.1 nm polydispersity index (PDI) 0.244, which is deemed ideal tumor targeting. A zeta potential (ζ-potential) value 16.4 mV good stability. IC 50 cells 9.7 0.19 load. In addition, increased production reactive oxygen species (ROS) changes mitochondrial membrane (MMP) observed. Gene expression studies that due activation Unc-51-like autophagy-activating kinase (ULK1) mediated autophagy nuclear factor kappa B (NF-κB) signaling besides inhibiting epithelial–mesenchymal Transition (EMT). less toxic NCTC clone 929 (L929) fibroblasts comparison possessed excellent (less than 2% hemolysis). Conclusion: physicochemical properties suitable particles effectively normal hemocompatibility. very low hemolytic profile indicates could administered intravenously therapy. Keywords: rCNPs, Hep3B, ROS, qPCR,

Язык: Английский

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Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example

Journal of Molecular Histology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Mechanistic analysis for identifying the anti-diabetic effects of Cholic acid-loaded chitosan nanoparticles: An in vitro approach

Journal of King Saud University - Science, Год журнала: 2024, Номер 36(10), С. 103480 - 103480

Опубликована: Окт. 10, 2024

Язык: Английский

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