Zein-Based Nanocarrier of the Insecticide Cyantraniliprole for the Control of Bemisia tabaciMEAM1 (Whitefly)

ACS Agricultural Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Язык: Английский

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Zein-based nanoparticulate systems: a journey through fabrication, targeting strategies and biomedical applications

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 48

Опубликована: Янв. 2, 2025

Zein, a plant-based protein obtained from the endosperm of corn (

Язык: Английский

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Evaluation of Zein Nanoparticles as Delivery Agents of SARS-CoV-2 Antigens

Vaccines, Год журнала: 2025, Номер 13(2), С. 139 - 139

Опубликована: Янв. 28, 2025

Background/Objectives: Nanovaccines have significant potential to enhance immunization strategies by improving efficacy, safety, and cost-effectiveness. In particular, organic nanoparticles hold promise for the generation of low-cost nanovaccines obtained environmentally friendly methods. this study, feasibility using zein (NPs) as carriers an antigenic peptide (p30) receptor binding domain (RBD) from SARS-CoV-2 spike protein was explored. Methods: A synthesis method NPs established combining previously reported techniques, resulting were characterized in terms morphology, particle size, polydispersity index (PDI), surface charge, colloidal stability dynamic light scattering (DLS) transmission electron microscopy (TEM). Tween 20 employed a surfactant prevent aggregation. Results: The deemed safe based on vitro cytotoxicity assay Vero cells. Immunogenicity assessments demonstrated that NPs:p30 NPs:RBD induced IgG responses test mice, whose magnitude comparable those achieved with alum adjuvant. Conclusions: These findings support use promising vaccine delivery vehicles adjuvant effects due their ease synthesis, high stability, low cost.

Язык: Английский

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Development, Safety, and Therapeutic Evaluation of Voriconazole-Loaded Zein–Pectin–Hyaluronic Acid Nanoparticles Using Alternative In Vivo Models for Efficacy and Toxicity

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 231 - 231

Опубликована: Фев. 11, 2025

Background/Objectives: Fungal infections caused by Candida species remain a significant clinical challenge, exacerbated limitations in current antifungal therapies, including toxicity and poor bioavailability. This study aimed to develop evaluate voriconazole-loaded zein-pectin-hyaluronic acid nanoparticles (ZPHA-VRC NPs) as novel drug delivery system enhance efficacy reduce toxicity. Alternative vitro vivo models were utilized assess the safety therapeutic potential of nanoparticles. Methods: ZPHA-VRC NPs prepared using nanoprecipitation method characterized for particle size, polydispersity index, zeta potential, encapsulation efficiency. Antifungal activity was assessed via MIC assays against albicans, C. krusei, parapsilosis. Cytotoxicity evaluated on Vero cells, while Galleria mellonella Caenorhabditis elegans models. The further an infected model survival health scores. Results: exhibited favorable physicochemical properties, size approximately 192 nm, index 0.079, -24 mV, efficiency 34%. retained comparable free voriconazole significantly reducing cytotoxicity. In studies G. demonstrated that markedly improved rates, reduced fungal burden, enhanced scores models, outperforming drug. Additionally, superior profile, minimizing systemic maintaining efficacy. Conclusions: offer safer more effective VRC, addressing conventional formulations. integration alternative highlights their value preclinical research.

Язык: Английский

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Empowering innovative strategies: Utilizing polymer-based nanotechnology for the prevention, control, and detection of aflatoxins, ochratoxins, and fusarium toxins in food systems

Grain & Oil Science and Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Zein Nanoparticles Loaded with Vitis vinifera L. Grape Pomace Extract: Synthesis and Characterization

Nanomaterials, Год журнала: 2025, Номер 15(7), С. 539 - 539

Опубликована: Апрель 2, 2025

This study investigates the synthesis and characterization of zein nanoparticles (ZNp) loaded with grape pomace extract (GPE) from Vitis vinifera L. for applications in controlled release antioxidant delivery. Grape pomace, a byproduct winemaking industry, is rich bioactive compounds, including phenols flavonoids, which possess properties. To overcome limitations these such as photosensitivity thermal degradation, they were incorporated into using antisolvent technique. The physicochemical properties ZNp-GPE system thoroughly characterized, size, morphology, ζ-potential, total phenol content. Results showed high encapsulation efficiency (89–97%) favorable loading capacities. Characterization techniques, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), confirmed that GPE was successfully nanoparticles, thereby enhancing their process did not significantly alter spherical morphology resulted decrease particle size. Total content analysis effectively retained confirming potential efficient delivery systems antioxidants. approach only provides method protecting bioavailability natural antioxidants but also contributes to valorization agricultural waste, promoting sustainability bio-based industries.

Язык: Английский

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Nanobioinoculants and their applications in different sectors

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 3 - 20

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in modification of plant-based proteins for improved encapsulation performance

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114691 - 114691

Опубликована: Апрель 1, 2025

Язык: Английский

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Multifunctional hydrogel of zein-tartaric acid encapsulated with oregano essential oils to combat Pseudomonas aeruginosa through biofilm inhibition

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106934 - 106934

Опубликована: Апрель 1, 2025

Язык: Английский

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Nanoencapsulation of Turmeric Bioactive Compounds in Zein Nanoparticles: Optimization, Characterization, and Anticancer Potential

ChemistrySelect, Год журнала: 2025, Номер 10(16)

Опубликована: Апрель 1, 2025

Abstract Turmeric ( Curcuma longa ) is a rich source of bioactive compounds, particularly curcuminoids, known for their potent antioxidant, anti‐inflammatory, and anticancer properties. However, hydrophobic nature limits bioavailability. This study aimed to encapsulate turmeric extract in zein nanoparticles coated with sodium caseinate chitosan enhance stability bioactivity. The demonstrated high antioxidant activity: (DPPH (2,2‐diphenyl‐1‐picrylhydrazyl): 94.15%, ABTS: 82.46%, Fe(II) chelation: 57.05%) contained significant phenolic (1737.13 mg GAE (equivalent gallic acid)/100 g) flavonoid (5548.77 RUE (mg rutin 100 g−1 the sample)/100 content. Nanoparticles were optimized at 1:0.8 zein/sodium ratio (183.53 nm), 10% loading (229.32 nm) 0.050% coating (226.51 nm). Encapsulation efficiency reached 66%, capacity 6.6%. Cytotoxicity assays revealed activity against renal (786‐0) liver (HUH7.5) tumor cells, suggesting therapeutic potential, respectively. highlights efficacy nanoencapsulation improving delivery bioactives pharmaceutical applications.

Язык: Английский

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