Implications of nanotechnology for the treatment of Dry Eye Disease: Recent advances

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125355 - 125355

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications

Theranostics, Год журнала: 2025, Номер 15(8), С. 3551 - 3570

Опубликована: Фев. 25, 2025

Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being particular concern due their severity and impact on quality life. Hyperglycemia-induced damage often results in range lesions, including diabetic retinopathy (DR), keratopathy, cataracts, glaucoma. These conditions impose considerable physical discomfort patients place substantial economic burden healthcare advent nanotechnology has facilitated the development innovative therapeutic strategies for managing complications. This review highlights several common complications associated DM, focusing pathogenesis treatment strategies. Emphasis placed applications potential treating

Язык: Английский

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Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery

The Ocular Surface, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Nanomedicines for Dry Eye Syndrome: Targeting Oxidative Stress with Modern Nanomaterial Strategies

Molecules, Год журнала: 2024, Номер 29(16), С. 3732 - 3732

Опубликована: Авг. 7, 2024

Dry eye syndrome (DES) is a dynamic, chronic disease of the ocular surface and appendages caused by inflammation. The most common symptoms include redness, itching, blurred vision, resulting from dysfunction meibomian glands impaired tear-film production. Factors contributing to development DES environmental elements, such as UV radiation, internal hormonal imbalances. These factors increase oxidative stress, which exacerbates inflammation on accelerates DES. In recent years, incidence has risen, leading greater need develop effective treatments. Current treatments for dry are limited primarily focus alleviating individual symptoms, reducing surface. However, it crucial understand pathomechanism tailor treatment address underlying causes achieve best possible therapeutic outcomes. Therefore, in this review, we analyzed impact stress gain better understanding its examined recently developed nanosystems that allow drugs be delivered directly site.

Язык: Английский

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Biomimetic Curcumin-Loaded Liposomes for the Treatment of Dry Eyes and Meibomian Gland Dysfunction: An In Vivo Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(21), С. 6436 - 6436

Опубликована: Окт. 27, 2024

Background/Objectives: Meibomian gland dysfunction (MGD) and dry eye syndrome (DES) are common diseases characterized by altered tear film stability inflammation of the ocular surface, causing significant discomfort possible visual impairment. This study aimed to investigate efficacy curcumin-loaded liposomes (Lipo@Cur) compared cyclosporine A-loaded (Lipo@CycA) in experimental rabbit models MGD DES, with a focus on their ability improve reduce surface inflammation. Methods: DES were induced using complete Freund’s adjuvant (CFA) treated evaluate effect liposomal formulations break-up time (TBUT), clinical signs (telangiectasia, conjunctival hyperemia, meibomian foramen occlusion), corneal as well histological cells. Results: Lipo@Cur increased TBUT reduced inflammation, potentially approaching effectiveness clinically approved A encapsulated (Lipo@CycA). Histological analysis suggested improvements epithelial thickness goblet cell density groups, which may indicate reversal DES-induced damage surface. Conclusions: Plant-originated curcumin offers promising therapeutic strategy for management that patient outcomes addressing underlying inflammatory mechanisms these conditions.

Язык: Английский

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Global research hotspots and trends in anti-inflammatory studies in dry eye: a bibliometric analysis (2004–2024)

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 28, 2024

Inflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide comprehensive overview current status, hotspots and trends DE anti-inflammatory research through bibliometric analysis.

Язык: Английский

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