Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(21), С. 8118 - 8118

Опубликована: Окт. 30, 2020

Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic autoptic findings suggest multifaceted pathophysiology for ischemic just some cases are caused by severe or complicated plaques. Currently there no well-defined assessment of that satisfies all the observations sometimes underlying mechanism everyday ward misleading. In order better examine this provide future perspectives, important know analyze pathophysiological mechanisms underline it, because not always determined complication. Therefore, have more complete comprehension we propose an overview available paradigms, from activation microvascular dysfunction.

Язык: Английский

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The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19

npj Science of Food, Год журнала: 2020, Номер 4(1)

Опубликована: Окт. 5, 2020

Abstract COVID-19 is a pandemic disease caused by the novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2). This new viral infection was first identified in China December 2019, and it has subsequently spread globally. The lack of vaccine or curative treatment for necessitates focus on other strategies to prevent treat infection. Probiotics consist single mixed cultures live microorganisms that can beneficially affect host maintaining intestinal lung microbiota play major role human health. At present, good scientific evidence exists support ability probiotics boost immunity, thereby preventing colonization pathogens reducing incidence severity infections. Herein, we present clinical studies use probiotic supplementation tract These data lead promising benefits risk COVID-19. Further should be conducted assess combat

Язык: Английский

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Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19

Frontiers in Medicine, Год журнала: 2020, Номер 7

Опубликована: Июль 7, 2020

Background: Gastrointestinal disorders are frequent in COVID-19 and SARS-CoV-2 has been hypothesized to impact on host microbial flora gut inflammation, infecting intestinal epithelial cells. Since there currently no coded therapies or guidelines for treatment of COVID-19, this study aimed evaluate the possible role a specific oral bacteriotherapy as complementary therapeutic strategy avoid progression COVID-19. Methods: We provide report 70 patients positive hospitalized between March 9th April 4th, 2020. All had fever, required non-invasive oxygen therapy presented CT lung involvement imaging more than 50%. Forty-two received hydroxychloroquine, antibiotics, tocilizumab, alone combination. A second group 28 subjects same added with bacteriotherapy, using specialized formulation eight bacterial strains. Results: The two cohorts were comparable age, sex, laboratory values, concomitant pathologies, modality support. Within seventy-two hours, nearly all treated showed remission diarrhea other symptoms compared less half not supplemented group. estimated risk developing respiratory failure was eight-fold lower receiving bacteriotherapy. Both prevalence transferred ICU mortality higher among Conclusions: significant ameliorating clinical conditions infection. These results also stress importance gut-lung axis controlling disease.

Язык: Английский

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Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Апрель 8, 2021

In order to inhibit pathogenic complications and enhance animal poultry growth, antibiotics have been extensively used for many years. Antibiotics applications not only affect target pathogens but also intestinal beneficially microbes, inducing long-lasting changes in microbiota associated with diseases. The application of has other side effects like, barrier dysfunction, residues foodstuffs, nephropathy, allergy, bone marrow toxicity, mutagenicity, reproductive disorders, hepatotoxicity carcinogenicity, antibiotic-resistant bacteria, which greatly compromise the efficacy antibiotics. Thus, development new is necessary, while search antibiotic alternatives continues. Probiotics are considered ideal substitute; recent years, probiotic research concerning their during infections humans, aquaculture, poultry, livestock industry, emphasis on modulating immune system host, attracting considerable interest. Hence, adverse remedial probiotics infectious diseases become central points focus among researchers. live microorganisms, when given adequate quantities, confer good health host through different mechanisms. Among them, regulation response one most important A number studies investigated aspects probiotics. this review, we mainly summarize discoveries discuss two aspects: (1) infections; (2) modulatory non-infectious

Язык: Английский

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Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 29, 2022

The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It caused by severe acute respiratory syndrome 2 (SARS-CoV-2). A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea, nausea, or vomiting. Moreover, the and tracts are primary habitats human microbiota targets for SARS-CoV-2 infection they express angiotensin-converting enzyme-2 (ACE2) transmembrane protease serine (TMPRSS2) at levels. There accumulating evidence that significantly altered in with post-acute (PACS). Microbiota powerful immunomodulatory factors various diseases, diabetes, obesity, cancers, ulcerative colitis, Crohn's disease, certain viral infections. In present review, we explore associations between host terms their clinical relevance. Microbiota-derived metabolites components main mediators microbiota-host interactions influence immunity. Hence, discuss potential mechanisms which microbiota-derived modulate immune responses to infection. Finally, review a variety possible microbiota-based prophylaxes therapies PACS, including fecal transplantation (FMT), probiotics, prebiotics, metabolites, engineered symbiotic bacteria. This treatment strategy could mitigate virus-induced inflammation.

Язык: Английский

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Overview of the possible role of vitamin C in management of COVID-19

Pharmacological Reports, Год журнала: 2020, Номер 72(6), С. 1517 - 1528

Опубликована: Окт. 28, 2020

Язык: Английский

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Probiotics: Versatile Bioactive Components in Promoting Human Health

Medicina, Год журнала: 2020, Номер 56(9), С. 433 - 433

Опубликована: Авг. 27, 2020

The positive impact of probiotic strains on human health has become more evident than ever before. Often delivered through food, dietary products, supplements, and drugs, different legislations for safety efficacy issues have been prepared. Furthermore, regulatory agencies addressed various approaches toward these whether they authorize claims mentioning a disease's diagnosis, prevention, or treatment. Due to the diversity bacteria yeast strains, strict designed assess side effects post-market surveillance. One most essential delivery systems probiotics is within due great beneficial this system compared pharmaceutical products also increasing importance food nutrition. Modern lifestyle diseases lead an imbalance intestinal flora. Nonetheless, as amount use needs accurate calculations, factors should be taken into consideration. novelties review presentation administration potential adjuvant therapy in COVID-19. Thus, paper provides integrative overview aspects probiotics, from care applications safety, quality, control.

Язык: Английский

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Key Aspects in Nutritional Management of COVID-19 Patients

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(8), С. 2589 - 2589

Опубликована: Авг. 10, 2020

This review deals with the relationship among nutrition, immune system, and coronavirus disease 2019 (COVID-19). The influence of nutrients bioactive molecules present in foodstuffs on system activity, COVID-19 nutritional status patients, dietary recommendations for hospitalized patients are addressed. Deficient is probably due to anorexia, nausea, vomiting, diarrhea, hypoalbuminemia, hypermetabolism, excessive nitrogen loss. There limited knowledge regarding support during hospital stay patients. However, therapy appears as first-line treatment should be implemented into standard practice. Optimal intake all nutrients, mainly those playing crucial roles assured through a diverse well-balanced diet. Nevertheless, order reduce risk consequences infections, intakes some micronutrients may exceed recommended allowances since infections other stressors can micronutrient status. In case critically ill recently published guidelines available their management. Further, several natural compounds interact angiotensin-converting enzyme 2 (ACE2) receptor, gateway severe acute respiratory syndrome (SARS) (SARS-CoV-2). Natural also inflammatory response induced by SARS-CoV-2. These potential beneficial tools management

Язык: Английский

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Dietary supplements and nutraceuticals market growth during the coronavirus pandemic – Implications for consumers and regulatory oversight

PharmaNutrition, Год журнала: 2021, Номер 18, С. 100282 - 100282

Опубликована: Сен. 3, 2021

Язык: Английский

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Microbiota’s role in health and diseases

Environmental Science and Pollution Research, Год журнала: 2021, Номер 28(28), С. 36967 - 36983

Опубликована: Май 27, 2021

Язык: Английский

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