Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
Insomnia
and
depression,
both
significantly
impacting
public
health,
are
common
psychosomatic
illnesses
that
frequently
co-occur
in
the
same
individual.
Not
only
do
these
two
conditions
commonly
co-occur,
but
they
also
exhibit
a
bidirectional
link,
where
existence
of
one
may
heighten
risk
for
other.
Latest
research
offers
compelling
evidence
significant
overlap
biological,
psychological,
sociological
aspects
comorbidity
insomnia
depression.
Building
on
this,
we
aim
to
examine
pathophysiology
along
with
their
comorbid
mechanisms,
encompassing
biological
routes
(like
genetics,
HPA
axis,
immune-inflammatory
activation,
neuroendocrine
regulation,
microbiome
alterations,
neural
circuits
integrating
sleep
emotion
regulation),
as
well
psychosocial
routes.
Consequently,
proposing
self-perpetuating
mutually
reinforcing
“snowball
effect”
model
examining
corresponding
preventative
intervention
strategies
rectify
associated
imbalances.
Finally,
this
article
encapsulates
challenges
field
study
directions
future
research.
paper
points
out
limitations
current
(cross-sectional
data
being
dominant,
mechanism
multi-omics
dynamics
unknown)
direction
(longitudinal
cohort
combined
computational
modeling
resolve
temporal
interactions),
which
will
provide
theoretical
basis
precision
interventions.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9366 - 9366
Опубликована: Авг. 29, 2024
The
human
gastrointestinal
tract
hosts
a
complex
and
dynamic
community
of
microorganisms
known
as
the
gut
microbiota,
which
play
pivotal
role
in
numerous
physiological
processes,
including
digestion,
metabolism,
immune
function.
Recent
research
has
highlighted
significant
impact
diet
on
microbiota
composition
functionality,
consequential
effects
host
health.
Concurrently,
there
is
growing
evidence
linking
to
inflammation,
key
factor
many
chronic
diseases
such
inflammatory
bowel
disease
(IBD),
obesity,
diabetes,
cardiovascular
(CVDs).
This
review
explores
how
dietary
components
influence
composition,
these
microbial
changes
affect
pathways,
therapeutic
implications
modulating
this
axis
for
prevention
management.
Beneficial
patterns,
Mediterranean
(MD)
plant-based
diets,
promote
diverse
balanced
supporting
anti-inflammatory
pathways.
Conversely,
Western
(WD),
high
saturated
fats
refined
sugars,
associated
with
dysbiosis
increased
inflammation.
With
all
links
between
three
variables
considered,
attempts
offer
thorough
examination
triangle
formed
by
food.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 2, 2024
More
than
20%
of
American
adults
live
with
a
mental
disorder,
many
whom
are
treatment
resistant
or
continue
to
experience
symptoms.
Other
approaches
needed
improve
health
care,
including
prevention.
The
role
the
microbiome
has
emerged
as
central
tenet
in
and
physical
their
interconnectedness
(well-being).
Under
normal
conditions,
healthy
promotes
homeostasis
within
host
by
maintaining
intestinal
brain
barrier
integrity,
thereby
facilitating
well-being.
Owing
multidirectional
crosstalk
between
neuro-endocrine-immune
systems,
dysbiosis
is
main
driver
immune-mediated
systemic
neural
inflammation
that
can
promote
disease
progression
detrimental
well-being
broadly
particular.
In
predisposed
individuals,
immune
dysregulation
shift
autoimmunity,
especially
presence
psychological
triggers.
chronic
stress
response
involves
system,
which
intimately
involved
gut
microbiome,
particularly
process
education.
This
interconnection
forms
microbiota-gut-immune-brain
axis
disorders.
this
brief
review,
we
aim
highlight
relationships
stress,
health,
along
ways
dysregulated
system
an
autoimmune
concomitant
neuropsychological
consequences
context
axis.
Finally,
review
evidenced-based
prevention
strategies
potential
therapeutic
targets.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 15, 2022
Colorectal
cancer
(CRC)
is
one
of
the
most
common
malignant
carcinomas.
CRC
characterized
by
asymptomatic
onset,
and
patients
are
already
in
middle
advanced
stages
disease
when
they
diagnosed.
Inflammatory
bowel
(IBD)
inflammatory-cancer
transformation
colorectal
adenoma
main
causes
CRC.
There
an
urgent
need
for
effective
prevention
intervention
strategies
In
recent
years,
rapid
research
progress
has
increased
our
understanding
gut
microbiota.
Meanwhile,
with
deepening
on
pathogenesis
cancer,
microbiota
been
confirmed
to
play
a
direct
role
occurrence
treatment
cancer.
Strategies
regulate
have
potential
value
application
Regulation
important
ways
natural
products
exert
pharmacological
effects,
especially
metabolic
diseases
tumours.
This
review
summarizes
tumorigenesis
mechanism
which
reduce
improve
therapeutic
response.
We
point
out
that
regulation
may
serve
as
means
Nutrients,
Год журнала:
2022,
Номер
14(10), С. 2161 - 2161
Опубликована: Май 23, 2022
Anthocyanins
are
mainly
purple-coloured
phenolic
compounds
of
plant
origin
that
as
secondary
metabolites
important
in
survival.
Understanding
their
health
benefits
humans
requires
sourcing
these
unstable
sufficient
quantities
at
a
reasonable
cost,
which
has
led
to
improved
methods
extraction.
Dark-coloured
fruits,
cereals
and
vegetables
current
sources
compounds.
The
range
potential
sustainable
is
much
larger
includes
non-commercialised
native
plants
from
around
the
world
agri-waste
containing
anthocyanins.
In
last
5
years,
there
have
been
significant
advances
developing
therapeutic
anthocyanins
chronic
human
diseases.
exert
beneficial
effects
through
improvements
gut
microbiota,
oxidative
stress
inflammation,
modulation
neuropeptides
such
insulin-like
growth
factor-1.
Their
include
reduced
cognitive
decline;
protection
organs
liver,
well
cardiovascular
system,
gastrointestinal
tract
kidneys;
bone
obesity;
regulation
glucose
lipid
metabolism.
This
review
summarises
some
mechanisms
treatment
Brain Sciences,
Год журнала:
2023,
Номер
13(8), С. 1226 - 1226
Опубликована: Авг. 21, 2023
The
human
gut
microbiota
is
a
complex
ecosystem
of
mutualistic
microorganisms
that
play
critical
role
in
maintaining
health
through
their
individual
interactions
and
with
the
host.
normal
gastrointestinal
plays
specific
physiological
function
host
immunomodulation,
nutrient
metabolism,
vitamin
synthesis,
xenobiotic
drug
maintenance
structural
functional
integrity
mucosal
barrier,
protection
against
various
pathogens.
Inflammation
innate
immune
response
living
tissues
to
injury
damage
caused
by
infections,
physical
chemical
trauma,
immunological
factors,
genetic
derangements.
Most
diseases
are
associated
an
underlying
inflammatory
process,
inflammation
mediated
contribution
active
cells.
Current
strategies
control
pathways
include
pharmaceutical
drugs,
lifestyle,
dietary
changes.
However,
this
remains
insufficient.
Bioactive
compounds
(BCs)
nutritional
constituents
found
small
quantities
food
plant
extracts
provide
numerous
benefits
beyond
value.
BCs
known
for
antioxidant,
antimicrobial,
anticarcinogenic,
anti-metabolic
syndrome,
anti-inflammatory
properties.
have
been
shown
reduce
destructive
effect
on
inhibiting
or
modulating
effects
mediators,
offering
hope
patients
suffering
from
chronic
disorders
like
atherosclerosis,
arthritis,
bowel
diseases,
neurodegenerative
diseases.
aim
present
review
summarise
natural
bioactive
protecting
health,
safety
preserve
improve
physiology
behaviour.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 1984 - 1984
Опубликована: Фев. 6, 2024
Dermatoses
are
an
increasingly
common
problem,
particularly
in
developed
countries.
The
causes
of
this
phenomenon
include
genetic
factors
and
environmental
elements.
More
more
scientific
reports
suggest
that
the
gut
microbiome,
specifically
its
dysbiosis,
also
plays
important
role
induction
progression
diseases,
including
dermatological
diseases.
microbiome
is
recognised
as
largest
endocrine
organ,
has
a
key
function
maintaining
human
homeostasis.
In
review,
authors
will
take
close
look
at
link
between
gut-skin
axis
pathogenesis
dermatoses
such
atopic
dermatitis,
psoriasis,
alopecia
areata,
acne.
focus
on
probiotics
remodelling
alleviation
dermatoses.
Theranostics,
Год журнала:
2024,
Номер
14(6), С. 2304 - 2328
Опубликована: Янв. 1, 2024
The
gut
microbiota
is
a
crucial
component
of
the
intricate
microecosystem
within
human
body
that
engages
in
interactions
with
host
and
influences
various
physiological
processes
pathological
conditions.In
recent
years,
association
between
dysbiosis
tumorigenesis
has
garnered
increasing
attention,
as
it
recognized
hallmark
cancer
scientific
community.However,
only
few
microorganisms
have
been
identified
potential
drivers
tumorigenesis,
enhancing
molecular
understanding
this
process
substantial
importance
clinical
relevance
for
treatment.In
review,
we
delineate
impact
on
treatment
multiple
types
while
also
analyzing
associated
mechanisms.Moreover,
discuss
utility
data
diagnosis
patient
stratification.We
further
outline
current
research
harnessing
prospects
challenges
approach.
High-dose
radiation
exposure
results
in
gastrointestinal
(GI)
acute
syndrome
identified
by
the
destruction
of
mucosal
layer,
intestinal
growth
barrier
dysfunction,
and
aberrant
inflammatory
responses.
Further,
causes
gut
microbiome
dysbiosis
characterized
diminished
microbial
diversity,
mostly
commensal
bacteria,
spread
bacterial
pathogens
that
trigger
recruitment
immune
cells
production
pro-inflammatory
factors
lead
to
further
GI
tissue
damage.
Currently,
there
are
no
U.S.
Food
Drug
Administration
(FDA)
approved
countermeasures
can
treat
radiation-induced
injuries.
To
meet
this
critical
need,
Synedgen
Inc.
has
developed
a
glycopolymer
radiomitigator
(MIIST305)
is
specifically
targeted
tract,
which
acts
intercalating
into
mucus
layer
glycocalyx
epithelial
could
potentially
ameliorate
deleterious
effects
radiation.
Male
C57BL/6J
adult
mice
were
exposed
13
Gy
partial
body
X-irradiation
with
5%
bone
marrow
shielding
MIIST305
was
administered
on
days
1,
3,
5
post-irradiation.
Approximately
85%
animals
survived
irradiation
apparently
healthy
until
end
30-day
study
period.
In
contrast,
control,
Vehicle-treated
past
day
10
at
dose.
We
show
improved
function
suppressed
systemic
responses
mediated
cytokines.
Taxonomic
profiling
community
structure
fecal
colonic
mucosa
microbiota
demonstrated
treatment
increased
diversity
restored
abundance
beneficial
including
Lactobacillus
Bifidobacterium
genera
while
suppressing
pathogenic
bacteria
Enterococcus
Staphylococcus
compared
animals.
summary,
novel
GI-targeted
therapeutic
greatly
enhances
survival
lethal
protects
tract
from
injury
restoring
balanced
reducing
Further
development
drug
as
an
FDA-approved
medical
countermeasure
importance.
