International Journal of Food Sciences and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 19, 2024
This
comprehensive
review
examines
the
impact
of
dietary
patterns
on
gut
microbiome
composition
and
diversity
from
infancy
to
old
age,
linking
these
changes
age-related
health
outcomes.
It
investigates
how
develops
across
life
stages,
focusing
influence
factors.
The
explores
early-life
feeding
practices,
including
breastfeeding
formula
feeding,
shape
infant
microbiota
have
lasting
effects.
In
elderly
individuals,
alterations
in
are
associated
with
increased
susceptibility
infections,
chronic
inflammation,
metabolic
disorders
cognitive
decline.
critical
role
diet
modulating
throughout
is
emphasised,
particularly
potential
benefits
probiotics
fortified
foods
promoting
healthy
ageing.
By
elucidating
mechanisms
connecting
food
systems
health,
this
provides
insights
into
interventions
that
could
enhance
resilience
improve
outcomes
lifespan.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(32), С. 12203 - 12215
Опубликована: Авг. 2, 2023
Selenopeptides
are
promising
candidates
for
intervening
in
neuroinflammation;
however,
the
key
role
of
selenium
(Se)
selenopeptides
remains
poorly
understood.
To
address
this
gap,
we
compared
neuroprotective
effects
selenopeptide
Val-Pro-Arg-Lys-Leu-SeMet
(namely,
Se–P1)
and
its
native
peptide
Val-Pro-Arg-Lys-Leu-Met
P1).
Our
results
demonstrate
that
Se–P1
treatment
exhibits
superior
antioxidant
antineuroinflammatory
PC12
cells
lipopolysaccharide
(LPS)-injured
mice
to
P1.
Moreover,
administration
P1
resulted
a
shift
gut
microbiota
composition.
Notably,
during
LPS-induced
injury,
demonstrated
greater
stability
maintaining
composition
treatment.
Specifically,
may
have
positive
impact
on
dysbiosis
by
modulating
inflammatory-related
bacteria
such
as
enhancing
Lactobacillus
abundance
while
reducing
Lachnospiraceae_NK4A136_group.
Furthermore,
alteration
metabolites
induced
exhibited
significant
correlation
with
microbiota,
subsequently
metabolic
pathways
including
histidine
metabolism,
lysine
degradation,
purine
metabolism.
These
findings
suggest
organic
Se
contributes
bioactivities
mitigating
neuroinflammation
LPS-injured
hold
value
development
potential
preventive
or
therapeutic
strategies
against
neurodegenerative
diseases
introduce
novel
concepts
nutrition
supplementation
recommendations.
Toxins,
Год журнала:
2023,
Номер
15(8), С. 499 - 499
Опубликована: Авг. 11, 2023
Residual
kidney
function
for
patients
with
chronic
disease
(CKD)
is
associated
better
quality
of
life
and
outcome;
thus,
strategies
should
be
implemented
to
preserve
function.
Among
the
multiple
causes
that
promote
damage,
gut
dysbiosis
due
increased
uremic
toxin
production
endotoxemia
need
attention.
Several
have
been
proposed
modulate
microbiota
in
these
patients,
diet
has
gained
increasing
attention
recent
years
since
it
primary
driver
dysbiosis.
In
addition,
medications
faecal
transplantation
may
valid
strategies.
Modifying
composition
mitigate
damage
residual
Although
various
studies
shown
influential
role
modulating
composition,
effects
this
modulation
on
remain
limited.
This
review
discusses
metabolism
vice
versa
how
we
could
by
balance.
Health Sciences Review,
Год журнала:
2023,
Номер
9, С. 100115 - 100115
Опубликована: Сен. 7, 2023
Colon
cancer
remains
one
of
the
leading
causes
morbidity
and
mortality
worldwide.
Given
its
widespread
prevalence,
identification
new
anticancer
drugs
is
crucial.
Medicinal
plants
have
provided
many
natural
products
that
proven
to
be
successful
in
clinical
use
shown
significant
efficacy.
Over
last
decade,
researchers
gathered
information
regarding
contribution
gut
microbiota
development
progression
colon
cancer.
Manipulating
reverse
microbial
dysbiosis
an
innovative
strategy
for
addressing
human
diseases
intestinal
disorders.
Recent
scientific
findings
this
approach
has
a
positive
impact
on
prevention
treatment
This
review
aims
provide
comprehensive
understanding
fundamental
concepts
related
dysbiosis,
as
well
interactions
between
phytochemicals
can
affect
bioavailability
bioactivity
these
compounds.
The
primary
components
gut,
including
carbohydrates,
enzymes,
lipids,
vitamins,
secondary
metabolites
such
alkaloids,
flavonoids,
polyphenols,
terpenoids,
activate
dysbiosis.
While
strategies
show
promising
outcomes
by
rectifying
proportion,
modifying
innate
immune
systems,
emphasizing
barrier
operation,
inhibiting
pathogen
colonization,
exhibiting
selective
cytotoxicity
against
cells,
further
research
necessary
fully
understand
their
mechanisms
action.
also
highlights
relationship
medicinal
plants,
microbiota,
cancer,
which
may
lead
translation
potential
microbiota-based
prevention.
International Journal of Food Sciences and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 19, 2024
This
comprehensive
review
examines
the
impact
of
dietary
patterns
on
gut
microbiome
composition
and
diversity
from
infancy
to
old
age,
linking
these
changes
age-related
health
outcomes.
It
investigates
how
develops
across
life
stages,
focusing
influence
factors.
The
explores
early-life
feeding
practices,
including
breastfeeding
formula
feeding,
shape
infant
microbiota
have
lasting
effects.
In
elderly
individuals,
alterations
in
are
associated
with
increased
susceptibility
infections,
chronic
inflammation,
metabolic
disorders
cognitive
decline.
critical
role
diet
modulating
throughout
is
emphasised,
particularly
potential
benefits
probiotics
fortified
foods
promoting
healthy
ageing.
By
elucidating
mechanisms
connecting
food
systems
health,
this
provides
insights
into
interventions
that
could
enhance
resilience
improve
outcomes
lifespan.
