The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июнь 19, 2024

The thyroid gland regulates most of the physiological processes. Environmental factors, including climate change, pollution, nutritional changes, and exposure to chemicals, have been recognized impact function health. Thyroid disorders cancer increased in last decade, latter increasing by 1.1% annually, suggesting that environmental contaminants must play a role. This narrative review explores current knowledge on relationships among factors anatomy function, reporting recent data, mechanisms, gaps through which act. Global warming changes living both iodine-poor areas volcanic regions can represent threat favor cancers because low iodine intake heavy metals radon. Areas with high nitrate nitrite concentrations water soil also negatively affect function. Air particularly particulate matter outdoor air, worsen be carcinogenic. endocrine-disrupting chemicals alter many ways, as some mimic and/or disrupt hormone synthesis, release, action target tissues, such bisphenols, phthalates, perchlorate, per- poly-fluoroalkyl substances. When discussing diet nutrition, there is evidence microbiome-associated an elevated consumption animal fat would associated production autoantibodies. There negative effects microplastics. Finally, infectious diseases significantly function; recently, lessons learned from SARS-CoV-2 pandemic. Understanding how influence crucial for developing preventive strategies policies guarantee appropriate development healthy metabolism new generations preventing disease adults elderly. However, are understanding warrant further research.

Язык: Английский

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Novel strategies for controlling nitrite content in prepared dishes: Current status, potential benefits, limitations and future challenges

Food Research International, Год журнала: 2023, Номер 170, С. 112984 - 112984

Опубликована: Май 18, 2023

Язык: Английский

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Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances

Pharmacological Reviews, Год журнала: 2024, Номер 76(6), С. 1038 - 1062

Опубликована: Июнь 12, 2024

Nitric oxide (NO) from endothelial NO synthase (eNOS) importantly contributes to vascular homeostasis. Reduced production or increased scavenging during disease conditions with oxidative stress contribute dysfunction and deficiency. In addition the classical enzymatic NOS system, can also be generated via nitrate-nitrite-NO pathway. Dietary pharmacological approaches aimed at increasing bioactivity, especially in cardiovascular have been focus of much research since discovery this small gaseous signaling molecule. Despite wide appreciation biological role NOS/NO signaling, questions still remain about chemical nature NOS-derived bioactivity. Recent studies show that NO-like bioactivity efficiently transduced by mobile NO-ferroheme species which transfer between proteins, partition into a hydrophobic phase, directly activate sGC-cGMP-PKG pathway without intermediacy free NO. Moreover, interaction red blood cells endothelium regulation homeostasis gained attention, cardiometabolic disease. review we discuss both non-classical pathways for generation how these modulated therapeutic purposes. Significance Statement After four decades intensive research, persist transduction control Here health disease, highlighting new findings, such as important Non-classical modes, like pathway, opportunities related system are discussed. Existing potential treatments/strategies, well dietary components influencing covered.

Язык: Английский

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Effects of Animal-Based and Plant-Based Nitrates and Nitrites on Human Health: Beyond Nitric Oxide Production

Biomolecules, Год журнала: 2025, Номер 15(2), С. 236 - 236

Опубликована: Фев. 7, 2025

Nitrate (NO3) and nitrite (NO2) are important nitrogen compounds that play a vital role in the cycle, contributing to plant nutrition broader ecological functions. Nitrates produced from nitric acid (HNO3), while nitrites come nitrous (HNO2). These substances commonly found environment, especially food water, due contamination both human natural sources. Human activities major contributors high levels of nitrates leading environmental pollution. Although is crucial for growth, excessive fertilizer use has caused disruptions. In plants, tend accumulate primarily leaves non-leguminous crops, such as leafy vegetables, which known their nitrate content. Furthermore, added animal-based foods, processed meats cheeses, prevent bacterial slow spoilage, improve flavor color. The concentration these can vary different factors like farming practices, climate, soil conditions, production methods. This review seeks examine differences between plant-based sources assess potential impact on health, considering also paradigm goes beyond oxide production.

Язык: Английский

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Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Окт. 21, 2022

Thyroid disruptors are found in food, atmosphere, soil, and water. These contaminants interfere with the thyroid function through impairment of hormone synthesis, plasma transport, peripheral metabolism, transport into target cells, action. It is well known that iodide uptake mediated by sodium-iodide symporter (NIS) first limiting step involved hormones production. Therefore, it has been described several regulation NIS expression and/or activity. Perchlorate, nitrate, thiocyanate competitively inhibit NIS-mediated uptake. mainly water smoke cigarettes. Although impact human exposure to these anions highly controversial, some studies indicated their deleterious effects function, especially individuals living iodine deficient areas. Considering critical role production for growth, development, this review summarizes NIS-inhibitors on consequences health.

Язык: Английский

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Obesity and main urologic cancers: Current systematic evidence, novel biological mechanisms, perspectives and challenges

Seminars in Cancer Biology, Год журнала: 2023, Номер 91, С. 70 - 98

Опубликована: Март 7, 2023

Язык: Английский

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N‐Nitrosamines: a potential hazard in processed meat products

Journal of the Science of Food and Agriculture, Год журнала: 2023, Номер 104(5), С. 2551 - 2560

Опубликована: Ноя. 21, 2023

Nitrite, nitrate, and their salts are added to processed meat products improve color, flavor, shelf life lower the microbial burden. N-Nitrosamine compounds formed when nitrosing agents (such as secondary nitrosamines) in interact with nitrites nitrates that have been meat. With consumption of such products, nitrosation reactions occur human body N-nitrosamine formation occurs gastrointestinal tract. Despite benefits on food, tendency create nitrosamines an increase body's nitrous amine load presents health risks. The inclusion nitrosamine possible probable carcinogen classes according International Agency for Research Cancer requires a re-examination literature review products. This article evaluates connections between various cancer types found © 2023 Society Chemical Industry.

Язык: Английский

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Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(3), С. 2403 - 2403

Опубликована: Янв. 29, 2023

Pancreatic cancer (PC) represents the 6th cause of death. Although aetiology PC is not completely understood, numerous risk factors have been identified in association with this cancer, among them diet. However, little known about between Mediterranean Diet (MedDiet) and PC. For reason, we conducted a systematic review meta-analysis according to PRISMA guidelines, searching on three databases (PubMed/MEDLINE, Scopus, EMBASE). The protocol was registered PROSPERO. Both fixed random effect models were performed. Effect size reported as hazard ratio (HR) 95% Confidence Interval (CI). A total eight articles included. methodological quality included meta-analyses high. Our results show that higher adherence MedDiet associated lower [HR:0.82 (0.76–0.88) p < 0.001, based 1,301,320 subjects]. also confirmed sensitivity subgroups analyses (avoidance potential overlapping effects, type tools used assess dietary intake diagnosis PC, prevalence incidence risk, country where studies took place, sex, site). Promoting could be an effective approach reduce

Язык: Английский

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From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Окт. 11, 2023

Abstract Current research has described improving multisystem disease and organ function through dietary nitrate (DN) supplementation. They have provided some evidence that these floras with (NO 3 − ) reductase are mediators of the underlying mechanism. Symbiotic bacteria activity (NRA) found in human digestive tract, including mouth, esophagus gastrointestinal tract (GT). Nitrate food can be converted to nitrite under tongue or stomach by symbiotic bacteria. Then, is transformed nitric oxide (NO) non-enzymatic synthesis. NO currently recognized as a potent bioactive agent biological activities, such vasodilation, regulation cardiomyocyte function, neurotransmission, suppression platelet agglutination, prevention vascular smooth muscle cell proliferation. also produced conventional l -arginine–NO synthase ( -NOS) pathway, whereas endogenous production -arginine inhibited hypoxia–ischemia conditions. In contrast, exogenous /NO 2 enhanced becomes practical supplemental pathway for body, playing an essential role various physiological activities. Moreover, many diseases (such metabolic geriatric diseases) primarily associated disorders synthesis, generation from route partially alleviate progression. The imbalance body may one potential mechanisms development. Therefore, impact on host systemic health direct ecological balance (e.g., homeostasis, amelioration diseases, etc.). This review summarizes humans, emphasizing relationship between processes this microflora disease. effects reduction were highlighted models different systems, digestive, cardiovascular, endocrine, nervous, respiratory, urinary providing innovative ideas future diagnosis treatment based

Язык: Английский

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Nitrate and body homeostasis

Medicine Plus, Год журнала: 2024, Номер 1(1), С. 100003 - 100003

Опубликована: Янв. 12, 2024

Homeostasis is essential for the maintenance of health, and how it maintained focus attention in homeostatic medicine. As a natural dietary nutrient, nitrate critical regulating homeostasis. This article summarizes nitrate's cognitive history, sources, metabolism. It discusses relationship possible mechanism between organism homeostasis from three aspects: flora homeostasis, inflammation-immunity energy metabolism as well clinical application scenarios promising new generation drugs, including preventing treating multi-system diseases, reducing injury, improving exercise ability, glucose lipid metabolism, assisting tumor treatment. An increased understanding impact on body could foster research concept its disease prevention

Язык: Английский

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