Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation

Microorganisms, Год журнала: 2023, Номер 11(8), С. 2083 - 2083

Опубликована: Авг. 14, 2023

Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in gut microbiota, which are influenced antibiotic use and other factors. Dysbiosis, develops persists as result earlier therapy, composition intestinal flora, can lead development various diseases such metabolic disorders, obesity, hematological malignancies, behavioral migraine. Metabolites produced microbiome have been shown influence gut–brain axis. The probiotics dietary supplement reduce number severity migraine episodes. Dietary strategies affect course migraines valuable tool for improving management. With fecal microbiota transplantation, microbial restoration more effective durable. Changes after transplantation were studied detail, many data help us interpret successful interventions. microbiological alteration microflora normalization inflammatory mediators, serotonin pathway, frequency intensity pain.

Язык: Английский

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New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Май 9, 2024

Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied nausea vomiting, associated various comorbidities such as brain cardiovascular diseases, which can have serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for treatment pain, long-term use leads to side effects drug addiction, emphasizes need investigate alternative pain management strategies fewer adverse effects. Complementary medicine viable intervention used in conjunction traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, acupressure, offer non-pharmacological alternatives that now options. This review focuses mechanistic doctrine migraine generation role potential mechanisms Alternative Therapies (CAT) migraine, summarizes research evidences CAT an adjunct or conventional therapies novel (calcitonin gene-related peptide (CGRP) antagonists pituitary adenylyl cyclase-activating (PACAP) antagonists) aim evaluating adjunctive treatment, thereby providing broader perspective design programs effective management.

Язык: Английский

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Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Nutrients, Год журнала: 2023, Номер 15(20), С. 4327 - 4327

Опубликована: Окт. 11, 2023

In the world, migraine is one of most common causes disability in adults. To date, there no a single cause for this disorder, but rather set physio-pathogenic triggers combination with genetic predisposition. Among factors related to onset, crucial role seems be played by gut dysbiosis. fact, it has been demonstrated how intestine able modulate central nervous system activities, through gut–brain axis, and dysbiosis can influence neurological pathologies, including attacks. context, addition conventional pharmacological treatments migraine, attention paid an adjuvant therapeutic strategy based on different nutritional approaches lifestyle changes positively microbiota composition. restoration balance between bacterial species, reconstruction barrier integrity, control release gut-derived inflammatory neuropeptides, obtained specific patterns changes, represent possible beneficial additive therapy many subtypes. Herein, review explores bi-directional correlation main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, kidney whose link represented

Язык: Английский

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Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur

Current Pain and Headache Reports, Год журнала: 2025, Номер 29(1)

Опубликована: Янв. 24, 2025

Язык: Английский

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Sex difference in TRPM3 channel functioning in nociceptive and vascular systems: an emerging target for migraine therapy in females?

The Journal of Headache and Pain, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 24, 2025

Transient Receptor Potential Melastatin 3 (TRPM3) channels are Ca2+ permeable ion that act as polymodal sensors of mechanical, thermal, and various chemical stimuli. TRPM3 highly expressed in the trigeminovascular system, including trigeminal neurons vasculature. Their presence dural afferents suggests they potential triggers migraine pain, which is originating from meningeal area. This area densely innervated by autonomous nerves contain major mediator calcitonin gene-related peptide (CGRP) peptidergic nerve fibers. Co-expression CGRP receptors a interplay between both signalling systems. Compared to other members TRP family, have high sensitivity sex hormones endogenous neurosteroid pregnenolone sulfate (PregS). The predominantly female estrogen progesterone, levels drop during menses, natural inhibitors channels, while PregS known agonist these channels. A decrease hormone has also been suggested trigger for attacks menstrually-related migraine. Notably, there remarkable difference TRPM3-mediated effects nociceptive In line with this, relaxation human isolated arteries induced activation greater females. Additionally, sex-dependent vasodilatory responses seem be influenced age-related hormonal changes, could contribute differences pathology. Consistent observations, sensory firing much more prominently than male mouse meninges, suggesting pain processing patients may differ. Overall, combined TRPM3-related neuronal vascular mechanisms provide possible explanation higher prevalence even severe quality narrative review summarizes recent data on roles pathophysiology, signalling, highlights prospects translational therapies targeting particular relevance women

Язык: Английский

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Migraine with and without aura—two distinct entities? A narrative review

The Journal of Headache and Pain, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 14, 2025

Язык: Английский

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Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature

Nutrients, Год журнала: 2023, Номер 15(14), С. 3170 - 3170

Опубликована: Июль 17, 2023

Consumption of caffeine in the diet, both daily and occasional, has a significant biological effect on nervous system. Caffeine, through various not yet fully investigated mechanisms, affects headaches. This is especially noticeable migraine. In other headaches such as hypnic headache, post-dural puncture headache spontaneous intracranial hypotension, an important therapeutic agent. turn, abrupt discontinuation chronically used can cause caffeine-withdrawal headache. Caffeine relieve trigger

Язык: Английский

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Non-Pharmacological Treatment of Primary Headaches—A Focused Review

Brain Sciences, Год журнала: 2023, Номер 13(10), С. 1432 - 1432

Опубликована: Окт. 8, 2023

Headache disorders are a significant global health burden, leading to reduced quality of life. While vast pharmacological treatments available, they may be associated with adverse effects or inadequate efficacy for some patients, therefore there is need exploring alternate treatment strategies. This review gives brief explanation and evaluation established emerging non-pharmacological approaches headache management, focusing on nutraceuticals diet, acupuncture, cognitive behavioral therapy (CBT), biofeedback, relaxation techniques, autogenic training, neuromodulation. Special consideration given psychological interventions as increase patient self-efficacy provide strategies managing chronic pain. Future research should focus optimizing these therapies, identifying patient-specific factors influencing their effectiveness, integrating them into holistic management

Язык: Английский

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Challenges and Pitfalls of Research Designs involving Magnesium-Based Biomaterials: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6242 - 6242

Опубликована: Июнь 5, 2024

Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a safe effective translation laboratory findings into practice. The utilization Mg-based biomedical devices eliminates need biomaterial removal surgery post-healing mitigates adverse effects associated with permanent implantation. high corrosion rate implants poses unexpected degradation, structural failure, hydrogen evolution, alkalization, cytotoxicity. biocompatibility degradability materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing impact material vivo still be improved. Several animal models, including rats, rabbits, dogs, pigs, explored assess potential magnesium-based Moreover, strategies alloying coating identified enhance degradation transform opportunities. This review aims explore Mg across applications within (in vitro) vivo) models.

Язык: Английский

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Practical supplements for prevention and management of migraine attacks: a narrative review

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Окт. 30, 2024

Migraine is one of the most debilitating neurological disorders that causes frequent attacks headaches and affects approximately 11% global population. Deficient or even insufficient levels vital nutrients would increase severity frequency migraine attacks. Therefore, we aimed to examine practical supplements for prevention management

Язык: Английский

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