Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial DOI Creative Commons

Asmaa Fatani,

Joon Hyuk Suh,

Jérémie Auger

и другие.

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июнь 30, 2023

Background Fiber is a potential therapeutic to suppress microbiota-generated uremic molecules. This study aimed determine if fiber supplementation decreased serum levels of molecules through the modulation gut microbiota in adults undergoing hemodialysis. Methods A randomized, double-blinded, controlled crossover was conducted. Following 1-week baseline, participants consumed muffins with added pea hull (PHF) (15 g/d) and control daily, each for 4 weeks, separated by 4-week washout. Blood stool samples were collected per period. Serum p -cresyl sulfate (PCS), indoxyl (IS), phenylacetylglutamine (PAG), trimethylamine N -oxide (TMAO) quantified LC–MS/MS, fecal profiled 16S rRNA gene amplicon sequencing specific taxa interest qPCR. QIIME 2 sample-classifier used discover unique profiles due consumption PHF. Results Intake PHF contributed an additional 9 g/d dietary subjects’ diet compliance. No significant changes from baseline observed PCS, IS, PAG, or TMAO, relative quantification Akkermansia muciniphila, Faecalibacterium prausnitzii, Bifidobacterium, Roseburia, considered health-enhancing. Dietary protein intake IS ( r = −0.5, 0.05) slow transit form PCS 0.7, < 0.01) significantly correlated at baseline. periods not differentiated; however, using machine learning, most distinguishing composition during compared usual alone enriched Gemmiger , Collinsella, depleted Lactobacillus Ruminococcus Coprococcus, Mogibacteriaceae. Conclusion did mitigate targeted microbial-generated Given high cellulose content, which may be resistant fermentation, exert sufficient effects on modulate its activity dose consumed.

Язык: Английский

Dietary therapy to halt the progression of diabetes to diabetic kidney disease DOI Creative Commons
Hongtu Hu, Guohua Ding, Wei Liang

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Diabetic Kidney Disease (DKD) is a common and serious complication of diabetes, particularly Type 2 Diabetes Mellitus (T2DM), which significantly contributes to patient morbidity mortality. The limitations traditional treatments like ACE inhibitors ARBs in managing DKD progression highlight the need for innovative therapeutic strategies. This review examines impact various dietary patterns, such as Mediterranean diet, ketogenic intermittent fasting, DASH vegetarian on management DKD. Evidence suggests these diets can halt DKD, although further research needed confirm their long-term effectiveness safety. Personalized approaches tailored individual needs may enhance outcomes patients.

Язык: Английский

Процитировано

0
Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial DOI Creative Commons

Asmaa Fatani,

Joon Hyuk Suh,

Jérémie Auger

и другие.

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июнь 30, 2023

Background Fiber is a potential therapeutic to suppress microbiota-generated uremic molecules. This study aimed determine if fiber supplementation decreased serum levels of molecules through the modulation gut microbiota in adults undergoing hemodialysis. Methods A randomized, double-blinded, controlled crossover was conducted. Following 1-week baseline, participants consumed muffins with added pea hull (PHF) (15 g/d) and control daily, each for 4 weeks, separated by 4-week washout. Blood stool samples were collected per period. Serum p -cresyl sulfate (PCS), indoxyl (IS), phenylacetylglutamine (PAG), trimethylamine N -oxide (TMAO) quantified LC–MS/MS, fecal profiled 16S rRNA gene amplicon sequencing specific taxa interest qPCR. QIIME 2 sample-classifier used discover unique profiles due consumption PHF. Results Intake PHF contributed an additional 9 g/d dietary subjects’ diet compliance. No significant changes from baseline observed PCS, IS, PAG, or TMAO, relative quantification Akkermansia muciniphila, Faecalibacterium prausnitzii, Bifidobacterium, Roseburia, considered health-enhancing. Dietary protein intake IS ( r = −0.5, 0.05) slow transit form PCS 0.7, < 0.01) significantly correlated at baseline. periods not differentiated; however, using machine learning, most distinguishing composition during compared usual alone enriched Gemmiger , Collinsella, depleted Lactobacillus Ruminococcus Coprococcus, Mogibacteriaceae. Conclusion did mitigate targeted microbial-generated Given high cellulose content, which may be resistant fermentation, exert sufficient effects on modulate its activity dose consumed.

Язык: Английский

Процитировано

5