Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер 109(12), С. e2324 - e2333

Опубликована: Фев. 14, 2024

Abstract Context The association between magnesium status and metabolic syndrome (MetS) remains unclear. Objective This study aimed to examine the relationship kidney reabsorption-related depletion score (MDS) MetS among US adults. Methods We analyzed data from 15 565 adults participating in National Health Nutrition Examination Survey (NHANES) 2003 2018. was defined according Cholesterol Education Program's Adult Treatment Panel III report. MDS is a scoring system developed predict of deficiency that fully considers pathophysiological factors influencing kidneys' reabsorption capability. Weighted univariate multivariable logistic regression were used assess MetS. Restricted cubic spline (RCS) analysis conducted characterize dose-response relationships. Stratified analyses by sociodemographic lifestyle also performed. Results In both analyses, higher significantly associated with increased odds Each unit increase approximately 30% risk for MetS, even after adjusting confounding (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted linear across range. positive correlation remained consistent various population subgroups exhibited no significant interaction age, sex, race, adiposity, smoking status, or alcohol consumption. Conclusion Higher urinary loss as quantified may be an independent factor adults, irrespective behavioral factors. Optimizing nutritional could potentially confer benefits patients

Язык: Английский

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Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Язык: Английский

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Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 13, 2024

Magnesium (Mg), an essential mineral abundantly present within the human body, is intricately involved in a multitude of biochemical processes vital for maintaining health and overall well-being. This review aims to delve into multifaceted impact Mg on health, exploring its physiological functions, dietary sources, potential implications deficiency or insufficiency. plays pivotal role various processes, including energy metabolism, muscle contraction, protein synthesis, DNA synthesis. It acts as cofactor more than 300 enzymatic reactions, facilitating conversion adenosine triphosphate (ATP) diphosphate (ADP) production. Moreover, proper functioning ion channels, particularly calcium influencing nerve transmission relaxation. naturally found wide array foods, with green leafy vegetables, whole grains, nuts, seeds, legumes being rich sources. Additionally, certain fortified foods supplements provide supplemental intake. Deficiency insufficiency mg can have profound health. Inadequate levels been associated increased risks chronic diseases, hypertension, type 2 diabetes, osteoporosis, cardiovascular diseases. Furthermore, may manifest symptoms such weakness, fatigue, tremors, irregular heartbeat. Numerous studies elucidated relationship between intake risk developing For instance, epidemiological evidence suggests that higher reduced possibly due vasodilatory effects influence blood pressure regulation mechanisms. Similarly, has implicated pathophysiology contributing insulin resistance impaired glucose metabolism. adequate crucial bone density reducing mineralization Understanding importance physiology underscores significance ensuring through diet supplementation. Healthcare professionals play critical educating individuals about incorporating mg-rich their diets considering supplementation when necessary, at those indispensable far-reaching Its involvement Ensuring preventing deficiency-related complications Further research warranted elucidate optimal strategies therapeutic applications disease prevention management.

Язык: Английский

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L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation

Nutrients, Год журнала: 2025, Номер 17(4), С. 665 - 665

Опубликована: Фев. 13, 2025

This narrative review provides an analysis of the role nitric oxide (NO) and its precursors, particularly L-arginine, in vascular regulation health, with emphasis on findings from our experimental research animal models. NO serves as a critical mediator function, contributing to vasodilation, blood flow, prevention thrombosis. As primary precursor NO, L-arginine is essential for maintaining endothelial integrity, modulating mitochondrial reducing oxidative damage. synthesises data contextualises these within physiological challenges faced by donors, such repeated donation associated stress. It examines effects supplementation respiration, lipid peroxidation, microsomal oxidation different conditions, including differences age, gender, dietary interventions. The mechanisms which enhances production, improves elasticity, alleviates dysfunction caused reduced bioavailability are also investigated. By integrating insights existing literature, this perspective potential address specific needs donors. highlights importance personalised nutritional approaches enhancing donor recovery resilience. In addition, assesses wider implications mitigating stress preserving function. interplay between bioavailability, factors, adaptation donors highlighted, along identification current knowledge gaps recommendations future research. presenting both original evidence synthesis article therapeutic promoting health context donation.

Язык: Английский

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Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue

Antioxidants, Год журнала: 2024, Номер 13(8), С. 893 - 893

Опубликована: Июль 24, 2024

Magnesium (Mg) is involved in essential cellular and physiological processes. Globally, inadequate consumption of Mg widespread among populations, especially those who consume processed foods, its homeostasis impaired obese individuals type 2 diabetes patients. Since deficiency triggers oxidative stress chronic inflammation, common features several frequent non-communicable diseases, interest this mineral growing clinical medicine as well biomedicine. To date, very little known about the role adipose tissue. In obesity, increase fat tissue leads to changes release cytokines, causing low-grade inflammation macrophage infiltration. Hypomagnesemia obesity can potentiate excessive production reactive oxygen species, mitochondrial dysfunction, decreased ATP production. Importantly, plays a regulating intracellular calcium concentration carbohydrate metabolism insulin receptor activity. This narrative review aims consolidate existing knowledge, identify research gaps, raise awareness critical supporting preventing stress.

Язык: Английский

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The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 4, 2025

Some evidence suggests magnesium might reduce serum levels of lipid profile. Due to the significance this matter on hand, we centralized our aim conduct a systematic review and meta-analysis interrogate effect supplementation total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high (HDL-C) in general population aged ≥ 18 years. In line with conducting study first, relevant articles were found through searching databases, including five databases: Cochrane Library, ClinicalTrials.gov, ISI Web Science, Scopus, PubMed until January 2024. Following fulfilling first aim, their mean differences standard deviations calculated meta-analysis. Ultimately, an assessment statistical heterogeneity intervention effects was performed using I-squared statistics Cochran's Q test. Regarding TC, TG, LDL-C, HDL-C, twenty-one, twenty-three, twenty, twenty-five studies included The pooled estimates showed no significant LDL-C between group comparison (weighted difference (WMD) = 0.34 mg/dl, 95% confidence interval (CI): -1.75 2.43, P 0.749, I2 99.1%; WMD=-2.06 CI: -6.35 2.23, 0.346, 99.1; WMD 1.71 -0.81 4.24, 0.183, 99.4, respectively). However, significantly increased HDL-C (WMD 1.21 0.58 1.85, < 0.001, 99.5). conclusion, that levels. due heterogeneity, must note more research is needed make robust recommendations regarding clinical practice. This registered PROSPERO under protocol number CRD42024505142.

Язык: Английский

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Changes in the Concentration Profile of Selected Micro- and Macro-Elements in the Yellow Ligament Obtained from Patients with Degenerative Stenosis of the Lumbo-Sacral Spine

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1252 - 1252

Опубликована: Фев. 14, 2025

Background/Objectives: Degenerative lumbo-sacral spinal stenosis is characterized by canal narrowing, often linked to ligamentum flavum hypertrophy. This study evaluated the elemental composition of tissue in DLSS patients compared healthy controls. Methods: involved 180 diagnosed with degenerative and 102 Ligamentum samples were analyzed for concentrations magnesium (Mg), calcium (Ca), phosphorus (P), zinc (Zn), copper (Cu), iron (Fe), sodium (Na), potassium (K), manganese (Mn), lead (Pb) using inductively coupled plasma optical emission spectrometry (ICP-OES). Statistical analyses conducted Student's t-test, ANOVA, Pearson's correlation, a significance threshold p < 0.05. Results: The group exhibited significantly elevated levels Mg (p 0.001), Ca = 0.014), P 0.006), along reduced Zn 0.021) Cu 0.038) No statistically significant differences observed Na, K, Mn, or Fe > 0.05). Elemental imbalances more pronounced individuals higher body mass index (BMI) varied gender. Pain intensity demonstrated correlation 0.012) Na 0.045), but no consistent associations Mg, Ca, P. Conclusions: Altered P, suggest their involvement pathophysiology. These elements may serve as potential biomarkers therapeutic targets mitigating narrowing.

Язык: Английский

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Targeting mineral metabolism in cancer: Insights into signaling pathways and therapeutic strategies

Seminars in Cancer Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Effects of probiotic and magnesium co-supplementation on mood, cognition, intestinal barrier function and inflammation in individuals with obesity and depressed mood: A randomized, double-blind placebo-controlled clinical trial

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Сен. 28, 2022

The co-occurrence of obesity and mood impairments named as "metabolic syndrome" (MMS) is often neglected in the management. This study aimed to evaluate effects Probio-Tec ®BG-VCap-6.5 magnesium co-supplementation on mood, cognition, intestinal barrier function serum C reactive protein (CRP) levels participants with depressed mood.Seventy-four eligible were randomly allocated either Probio-Tec®BG-VCap-6.5 [containing Lactobacillus rhamnosus (LGG®) Bifidobacterium animalis subsp. Lactis (BB-12®)] + Magnesium chloride or placebo for 9 weeks. Sociodemographic data collected beginning. Anthropometric, dietary physical activity (PA) assessments carried out. Beck Depression Inventory-II (BDI-II) Montreal Cognitive Assessment (MoCA) scores assessed through validated questionnaires. Fasting plasma zonulin, lipopolysaccharide (LPS) measured by ELIZA kits.Of seventy-four (mean age 37.51 ± 8.10), 52 completed study. Changes LPS zonulin not different significantly between groups (-3.04 44.75 ng/dl, 0.11 5.13, p > 0.05 1.40 48.78 -0.17 6.60, respectively). CRP reduced intervention group compared [-474.75 (-1,300.00, -125.00) mg/l vs. 175.20 (-957.75, 1,683.25) mg/l, = 0.016]. BDI-II MoCA (-7.13 5.67, 1.20 2.16, respectively) (-5.42 6.71, 1.94 1.86, (p 0.05).Nine weeks probiotic resulted decreased an indicator inflammatory state no significant cognition integrity individuals mood.

Язык: Английский

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Current opinion on the regulation of small intestinal magnesium absorption

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(2), С. 332 - 342

Опубликована: Янв. 5, 2023

Magnesium (Mg2+) has an important role in numerous biological functions, and Mg2+ deficiency is associated with several diseases. Therefore, adequate intestinal absorption of vital for health. The small intestine was previously thought to absorb digested exclusively through unregulated paracellular mechanism, which responsible approximately 90% total absorption. Recent studies, however, have revealed that the duodenum, jejunum, ileum both transcellular routes. Several regulatory factors uptake also been explored, e.g., parathyroid hormone, fibroblast growth factor-23, apical acidity, proton pump inhibitor, pH-sensing channel receptors. mechanistic underlying inhibitor suppression Mg2+, such as magnesiotropic protein dysfunction, higher mucosal bicarbonate secretion, Paneth cell inflammation, are currently being explored. potential microbiomes proposed. In this article, we reviewed current knowledge on mechanisms

Язык: Английский

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