The Association between the Atherogenic Index of Plasma and Cardiometabolic Risk Factors: A Review

Healthcare, Год журнала: 2023, Номер 11(7), С. 966 - 966

Опубликована: Март 28, 2023

Metabolic syndrome (MetS) is a condition caused by combination of cardiometabolic risk factors (CMR). MetS leads to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), both which place burden on not only the patients but also healthcare system. Diagnostic criteria for vary, there no universal tool detect it. Recently, many studies have found positive associations between atherogenic index plasma (AIP) some CMR factors. Therefore, comprehensive review was needed recapitulate these qualitatively estimate likelihood AIP being associated with CMR. We aimed summarise observational data verify their association.A conducted searching "atherogenic plasma" in PubMed, One Search, Cochrane library. A total 2068 articles were screened, 32 included after excluding paediatric, non-human interventional studies, those carried out cohorts conditions unrelated or lipid-lowering medication. The Newcastle-Ottawa scale used assess quality.Most that reported high waist circumference (WC), triglycerides (TG), insulin resistance (IR) low high-density lipoprotein cholesterol (HDL-C) concentration, AIP. Few investigated blood pressure (BP) discrepancies existed results.AIP may be WC, TG, IR, HDL-C. It unclear if BP. current study's results should inform futureward meta-analysis seen quantitatively. recommended more cohort stratified gender ethnicity performed ascertain can predict before it manifests.

Язык: Английский

---

Association between solid cooking fuels exposure and metabolic syndrome: Evidence from China

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117648 - 117648

Опубликована: Янв. 1, 2025

Epidemiological evidence connecting cooking fuel use to metabolic syndrome (MetS) is lacking. Solid usage and MetS prevalence were prospectively investigated in this study. We included participants 2011 2015 from the China Health Retirement Longitudinal Study (CHARLS) data. Through cross-sectional longitudinal studies, we found that of solid fuels reduced risk compared with clean (cross-sectional study: 2011: Odds ratio (OR): 0.819, 95 %confidence interval (CI): 0.747-0.897, P < 0.001; 2015: OR: 0.766, %CI: 0.708-0.851, 0.736, 0.652-0.831, 0.001).This impact ceases exist whenever a switch type occurs (Non persistent clean: 0.937, 0.837-1.050, = 0.262; Persistent solid: 0.767, 0.691-0.853, 0.001). Moreover, biomass (crop residue wood burning) combustion (OR: 0.653, 0.573-0.743, 0.001), while coal had no effect on 1.092, 0.907-1.315, 0.352). Based mediation analysis, triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) mediated 61.3 % 39.8 reduction observed fuel. In summary, our research showed household associated less risk. Among them, may play an important role.

Язык: Английский

---

Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12012 - 12012

Опубликована: Июль 27, 2023

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of pathogenesis metabolic mitochondrial dysfunction, which tissue hypoxia, disruption integrity, increased production reactive oxygen species, decrease ATP, leading chronic inflammatory state that affects tissues organ systems. The AAA + protease Lon (Lonp1) has broad spectrum activities. In addition its classical function (degradation misfolded or damaged proteins), enzymatic activity (proteolysis, chaperone activity, DNA (mtDNA)binding) been demonstrated. At same time, Lonp1 extends regulation cellular processes inside mitochondria, as well outside mitochondria (nuclear localization). This may be promising molecular target for development targeted therapy MetS components. aim this review elucidate role mtDNA components key dysfunction describe little-studied LonP1 potential disorders.

Язык: Английский

---

Chrononutrition in the Prevention and Management of Metabolic Disorders: A Literature Review

Nutrients, Год журнала: 2024, Номер 16(5), С. 722 - 722

Опубликована: Март 1, 2024

Background: The concept of time-restricted eating (TRE) or feeding (TRF) promotes daily periods and fasting to determine whole-body physiology. Chronic misalignment circadian rhythms chrono-disruption is related an increased risk diverse metabolic disorders. progression non-communicable diseases seems be affected by the timing meals. As a result, intermittent promising approach for their management. aim present literature review examine scrutinize TRE protocols in fields prevention management Methods: This thorough reported associations among rhythm, disorders, diabetes mellitus, obesity, TRE, TRF, dietary habits, disruption, cardiovascular diseases, atherosclerosis, non-alcoholic fatty liver find already existing clinical studies from last decade (2014–2024) most precise scientific online databases, using relevant specific keywords. Several inclusion exclusion criteria were applied only longitudinal, cross-sectional, descriptive, prospective human studies. Results: currently available findings remain scarce suggest that chrononutrition behaviors such as TRF may promote several benefits, mainly body weight control fat loss. Improvements glucose levels lipid profiles are quite controversial since some show little no effect. far concerned, efficacy stronger disease due decline Conclusions: Even if there has been gradual increase few years, providing perspectives, currently, conclusive evidence role Future should well-designed with longer duration larger sample sizes. Moreover, it important best window its feasibility.

Язык: Английский

---

Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO‐1 signaling, the microbiota‐gut‐brain axis, and hippocampal neuron ferroptosis

Phytotherapy Research, Год журнала: 2023, Номер 37(8), С. 3323 - 3341

Опубликована: Апрель 10, 2023

Abstract Recent years have witnessed a growing research interest in traditional Chinese medicine as neuroprotective nutrient the management of diabetic cognitive dysfunction. However, underlying molecular mechanisms sinomenine mediating ferroptosis hippocampal neurons been poorly understood. This study sought to decipher potential effect and mechanism dysfunction following type 2 diabetes mellitus (T2DM). Multi‐omics analysis was conducted identify microbiota‐gut‐brain axis T2DM patient samples obtained from publicly available database. In HT‐22 cells, erastin utilized create model, streptozotocin injected intraperitoneally rat model DM. It noted that intestinal flora imbalance occurred patients with T2DM‐associated Sinomenine could reduce Erastin‐induced hippocampus neuronal by increasing EGF expression. protected against activating Nrf2/HO‐1 signaling pathway. Furthermore, vivo results confirmed blocked alleviated rats. Collectively, these suggest confers effects curtailing neuron via EGF/Nrf2/HO‐1 axis. may be candidate for treatment

Язык: Английский

---

Association of Nightly Fasting, Meal Frequency, and Skipping Meals with Metabolic Syndrome among Kuwaiti Adults

Nutrients, Год журнала: 2024, Номер 16(7), С. 984 - 984

Опубликована: Март 28, 2024

Mounting evidence suggests that meal timing and frequency are associated with cardiometabolic health by influencing circadian rhythms. However, the is inconsistent limited, especially in non-Western cultures. This cross-sectional study aims to investigate association between temporal habits of dietary intake, such as nightly fasting duration frequency, metabolic syndrome among Kuwaiti adults. A 24-hour recall was used assess intake. Meal defined number daily eating episodes. The included a total 757 adults aged 20 years older. participants' mean age 37.8 ± 12.3 years. After adjusting for all confounders, higher found be lower prevalence (OR, 0.43; 95%CI, 0.19-0.96) elevated triglycerides men only 0.23; 0.09-0.60). No syndrome, but longer 0.19; 0.06-0.63). findings suggest having frequent meals durations may help decrease risk triglycerides.

Язык: Английский

---

Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 3, 2025

Stroke is a significant cerebrovascular disease and remains one of the leading causes death disability worldwide. Insulin resistance has been strongly linked to incidence stroke. Employing characteristics metabolic syndrome, Metabolic Score for Resistance (METS-IR) accurately measures insulin resistance. Nonetheless, relationship between METS-IR stroke risk not well-established. We analyzed data from National Health Nutrition Examination Survey (NHANES) covering years 2007-2018. Participants providing complete self-reported information were included in study. utilized weighted multivariate regression explore stroke, performing subgroup analyses as well. A total 14,794 participants included, with an average 43.44 ± 12.68. The overall prevalence was 3.79%, higher rates observed upper tertiles. An increase unit associated 1% (OR = 1.01; 95% CI: 1.01-1.02). Interaction tests indicated no effects gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. Notably, younger than 60 years, association significantly stronger 1.02; 1.01-1.03), marked interaction (p 0.0061). Our findings indicate positive correlation increased risk. Early intervention targeting may be viable preventive measure against particularly individuals under age.

Язык: Английский

---

Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank

Nutrition & Metabolism, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 30, 2025

Abstract Background and objectives Metabolic syndrome (MetS) its constituent comorbidities, along with mineral imbalances, pose a significant health burden in the Qatari population. Although Magnesium (Mg) Calcium (Ca) have been individually linked to MetS, impact of calcium-to-magnesium ratio (Ca: Mg) on MetS remains unclear, especially adult population Qatar. In this study, we aim investigate association between total serum concentrations Ca, Mg Ca: outcome MetS. Methods This comprehensive cross-sectional study included data 9693 participants collected by Qatar Biobank (QBB). The levels addition recorded metabolic parameters for participants, were used analyses. presence was deemed as our primary components secondary outcomes. Logistic regression models run examine these associations. Results conclusion present more than 19% mean higher non-MetS group 0.83 ± 0.06 mmol/L compared 0.81 0.08 mmol/L. Conversely, Ca (2.33 0.09 mmol/L, 2.92 0.36 mmol/L) (2.30 2.77 0.23 respectively. context observed negative dose-response relationship quartiles contrast, found positive well

Язык: Английский

---

miR‐92a aggravates metabolic syndrome via KLF2/miR‐483 axis

Journal of Diabetes Investigation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

To exam the role of miR-92a/KLF2/miR-483 in pathogenesis metabolic syndrome. In this study, serum healthy controls and patients with syndrome were collected to detect circulating level miR-92a miR-483. vitro cultured HUVECs, overexpression or suppression miR-92a, miR-483 KLF2 determine relationship among Ang II, ox-LDL, high glucose treatment used mimic HUVECs HepG2 cells treated Telmisartan, Atorvastatin, metformin, its target gene expression was detected. animal experiment, ob/ob mice chose confirm changes KLF2, Compared controls, significantly increased, while remarkably decreased HUVECS, reduced miR-483, but had no effect on miR-92a. Overexpression could downregulate level, inhibition opposite effect. When stimulated ox-LDL glucose, genes increased. Anti-miR-92a reverse Furthermore, Metformin increased expression, which be reversed by mimic. The cells, exosomes derived from endothelial overexpression. showed similar effects. Endothelial dysfunction fatty liver are critically involved MicroRNAs can mediate cellular communication between vascular (ECs) distal cell. Serum higher than controls. is increase production acts CTGF, ET-1, β-catenin protect cell function. EC secreted out into blood, circulates through blood liver, continues exert biological effects after being absorbed hepatocytes. LNA-miR-92a administration damage caused affecting KLF2/miR-483 pathway.

Язык: Английский

---

The effect of within-day energy distribution on lean body mass and body fat in athletes: A systematic review

International Journal of Sports Science & Coaching, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Nutritional practices have a significant effect on exercise performance as they determine not only acute energy availability for sport activities, but also long-term changes in body composition. This review summarizes the available evidence and explores critical relationship between within-day balance composition, emphasizing importance of even distribution optimal athletic health. Findings revealed that is factor regulation composition athletes, negative may impair muscle protein synthesis promote fat accumulation. The suggests athletes should an intake dynamically matches requirement (i.e., portion day when expenditure higher, be matched with higher intake) to avoid prolonged periods restriction. reviewed investigation emphasized hourly assessment, because reliance 24-h status insufficient athletes. However, due dearth scientific competitive more research needed balance, considering training goals, individual differences, dietary preferences.

Язык: Английский

---