Novel first-trimester serum biomarkers for early prediction of gestational diabetes mellitus

Nutrition and Diabetes, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 12, 2025

Gestational diabetes mellitus (GDM) is a common obstetric complication worldwide that seriously threatens maternal and fetal health. As the number of women conceiving through in vitro fertilization (IVF) continues to rise, this population recognized as being at an elevated risk for GDM. However, there still no consensus on early prediction GDM IVF patients due lack reliable biomarkers. We compared first-trimester serum cytokine antibody profiles 38 matched controls undergoing treatment, based extensive human biobank our large‑scale assisted reproductive cohort platform. The 76 samples were divided into training set (n = 53) testing 23) using 7:3 ratio, five diverse machine-learning models predicting constructed. By combining top differentially expressed first‑trimester biomarkers [including total immunoglobulin (Ig)G, IgM, interleukin (IL)-7, anti‑phosphatidylserine (aPS)-IgG immune complexes (IC), IL-15], novel model was constructed, which achieved superior predictive value [area under curve (AUC) 95% confidence interval (CI) 0.906 (0.840-0.971), with sensitivity 75% specificity 94.7%] development. eXtreme Gradient Boosting (XGBoost) AUC 0.995 (95% CI: 0.995-1.000, P < 0.001) 0.867 0.789-0.952, test identified cytokines immune-related constructed efficient population. These findings are expected aid development strategies offer immunological insights further mechanistic studies

Язык: Английский

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Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis

BMC Women s Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 18, 2025

In recent years, research interest in the potential link between female infertility (FI) and gynecological cancer (GC), including ovarian (OC), endometrial (EC), cervical (CC), breast (BC), has grown, yet findings remain inconclusive. This study aims to explore causal relationship FI GC using bidirectional two-sample Mendelian randomization (MR) analyses, thereby informing future strategies for prevention. We utilized SNPs identified from genome-wide association studies (GWAS) on GC. The inverse variance weighted (IVW) method served as primary approach assess Additionally, five other MR methods-Weighted median, Weighted mode, MR-Egger, Simple Robust-Adjusted Profile Score-were employed enhance result robustness credibility. forward analysis, our IVW results indicated no significant (FI-BC: OR = 0.95, 95% CI: 0.83-1.09, P 0.47, P-FDR 0.775; FI-OC: 1.01, 0.84-1.24, 0.789, 0.896; FI-CC: 0.80, 0.61-1.06, 0.118, FI-EC: 1.07, 0.88-1.30, 0.490, 0.775).In reverse we found a marginal BC FI. However, after adjusting multiple testing FDR method, was FI, suggesting (OR 1.054, 1.001-1.108, 0.043, 0.331). For cancers, relationships were observed OC, CC EC with FI(OC-FI: 1.043, 0.999-1.087, 0.051, 0.331;CC-FI: 0.992, 0.956-1.028, 0.654, 0.836; EC-FI: 1.006, 0.956-1.055, 0.809, 0.885). Our observed. These underscore need further confirm this emphasize importance of reproductive protection young patients preserve fertility.

Язык: Английский

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Effects of Calorie Restriction on Preserving Male Fertility Particularly in a State of Obesity

Current Obesity Reports, Год журнала: 2024, Номер 13(2), С. 256 - 274

Опубликована: Март 15, 2024

Язык: Английский

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Anti-COVID-19 Vaccination Alters the Menstrual Cycle and Dose Accumulation Enhances the Effect

Medicina, Год журнала: 2024, Номер 60(6), С. 956 - 956

Опубликована: Июнь 8, 2024

Background and Objectives: New investigations have detected an enhanced probability for women to develop menstrual cycle alterations after anti-COVID-19 vaccination. Moreover, given that the protective immunity provided by vaccination appears wane quickly, booster has been recommended. Nonetheless, whether adverse events arise from such repeated immunization not studied. Materials Methods: We studied incidence of alterations, quantity per subject, altered cycles in nonpregnant fertile age a cohort vaccinated female subjects means standardized questionary was applied via telephone calls each month. Subjects received up four doses were 6 months dose. calculated odds ratio incidence, as well quadratic functions tendencies. A sensitivity analysis excluding taking hormonal birth control those with polycystic ovary syndrome performed. Results: Anti-COVID-19 (OR 1.52, CI at 95% 1.2–1.8, p < 0.0001) and, interestingly, tendency when more (R2 = 0.91). Furthermore, same trends cycles. Such effect further demonstrated be independent upon vaccine brand being applied, status, diagnosis syndrome. Conclusions: Vaccination is most cost-effective measure primary prevention considered safe. this article, we show data suggest adult may lead cycle–related events, therefore think development new formulations produce longer-lasting paramount importance reduce potential dose accumulation–dependent risk.

Язык: Английский

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Associations of Nutrients and Dietary Preferences with Recurrent Pregnancy Loss and Infertility

Journal of Nippon Medical School, Год журнала: 2024, Номер 91(3), С. 254 - 260

Опубликована: Июнь 25, 2024

This review examines associations of nutrients and dietary preferences with recurrent pregnancy loss (RPL), miscarriage, infertility. Research articles, reviews, meta-analyses RPL infertility that focused on nutrition, meals, lifestyle were reviewed, are discussed in relation to recent research findings. Studies related given the highest priority, followed by those dealing miscarriage Multivitamin supplements-even when lacking folic acid or vitamin A-reduced total fetal loss. High-dose supplementation before conception reduced risk stillbirth. A meta-analysis revealed a strong association D deficiency/insufficiency miscarriage. Another seafood dairy products whereas caffeine intake 300 mg/day more was associated balanced diet included antioxidant properties helped prevent processed foods proinflammatory effects increased Associations warrant further research.

Язык: Английский

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Dietary Inflammatory Index and female infertility: findings from NHANES survey

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 19, 2024

Background and objectives Infertility is a pressing public health concern on national scale has been linked to inflammatory conditions. However, limited research conducted the impact of Dietary Inflammatory Index (DII) female infertility. This study sought investigate association between DII infertility utilizing data from National Health Nutrition Examination Survey (NHANES). Methods cross-sectional included cohort 3,071 women aged 20–44 years three NHANES cycles (2013–2018). information was collected calculate (DII), while status determined through positive responses specific questions in questionnaire. The scores assessed using adjusted multivariate logistic regression analyses. Subgroup analysis restricted cubic spline (RCS) for further investigation. Results Among participants, 354 (11.53%) were identified as experiencing Upon adjusting all covariates, correlation observed (OR = 1.61, 95% CI: 1.12–2.31). Individuals with highest quartile exhibited significantly greater odds compared those lowest 1.71, CI 1.17–2.51). relationship RCS models demonstrated an S-shaped curve. When median reference point, higher associated increased prevalence Additionally, obesity found be significant factor. Conclusions Our indicated that positively correlated likelihood American among ages 20 44. These results contribute existing literature underscore need validation larger prospective studies.

Язык: Английский

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How should the best human embryo in vitro be? Current and future challenges for embryo selection

Minerva Obstetrics and Gynecology, Год журнала: 2023, Номер 76(2)

Опубликована: Июнь 16, 2023

In-vitro fertilization (IVF) aims at overcoming the causes of infertility and lead to a healthy live birth. To maximize IVF efficiency, it is critical identify transfer most competent embryo within cohort produced by couple during cycle. Conventional static morphological assessment involves sequential observations under light microscope specific timepoints. The introduction time-lapse technology enhanced evaluation via continuous monitoring preimplantation in vitro development, thereby unveiling features otherwise undetectable multiple assessments. Although an association exists, blastocyst morphology poorly predicts chromosomal competence. In fact, only reliable approach currently available diagnose embryonic karyotype trophectoderm biopsy comprehensive chromosome testing assess non-mosaic aneuploidies, namely genetic for aneuploidies (PGT-A). Lately, focus shifting towards fine-tuning non-invasive technologies, such as "omic" analyses waste products (e.g., spent culture media) and/or artificial intelligence-powered morphologic/morphodynamic evaluations. This review summarizes main tools (or predict) developmental, chromosomal, reproductive competence, their strengths, limitations, probable future challenges.

Язык: Английский

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Application and discoveries of metabolomics and proteomics in the study of female infertility

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 10, 2024

Introduction Female infertility is defined as the absence of clinical pregnancy after 12 months regular unprotected sexual intercourse. Methods This study employed metabolomics and proteomics approaches to investigate relationship between metabolites proteins female infertility. The used data from UK Biobank identify linked Results results showed that GRAM domain-containing protein 1C fibrinogen cleavage peptides ADpSGEGDFXAEGGGVR 3-Hydroxybutyrate had a positive correlation with infertility, whereas such Interleukin-3 receptor subunit alpha, Thrombospondin type-1 1, Intestinal-type alkaline phosphatase, platelet endothelial cell adhesion molecule 1 exhibited negative correlation. These findings provide new clues targets for diagnosis treatment. However, further research required validate these gain deeper understanding specific roles in pathogenesis. Discussion In conclusion, techniques have significant application value allowing better biological mechanisms underlying providing insights strategies its crucial mechanistic basis early screening, prevention,

Язык: Английский

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The moderating effect of dietary selenium intake on the risk of infertility‐associated depressive symptoms in female

Journal of Obstetrics and Gynaecology Research, Год журнала: 2024, Номер 50(5), С. 899 - 908

Опубликована: Фев. 29, 2024

Abstract Aim To analyze the associations between infertility or dietary selenium intake and depressive symptoms as well role of on association in women. Methods This study retrieved data 4949 women from National Health Nutrition Examination Survey (NHANES) database. Univariable multivariable weighted logistic regression analyses were applied to assess with risk regulation related infertility. Results The elevated was found participants (odds ratio [OR] = 1.54, 95% confidence interval [CI]: 1.11–2.15). reduced ≥55 μg (OR 0.64, 95%CI: 0.46–0.90). Compared without who had <55 μg, those associated after adjusting for confounding factors 2.01, 1.03–3.90). not significantly increased comparison subjects ( p > 0.05). Conclusion Selenium regulated symptoms.

Язык: Английский

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Genes Linked to Obesity-Related Infertility: Bridging the Knowledge Gap

Reproductive and Developmental Medicine, Год журнала: 2024, Номер 8(2), С. 121 - 129

Опубликована: Март 28, 2024

Genetic factors play a pivotal role in the complex relationship between obesity and infertility. This article delves into genetics of obesity-related infertility, focusing on essential genes mechanisms both sexes. We explored infertility obese females, polycystic ovary syndrome (PCOS) influence like insulin receptor ( INSR ), androgen AR follicle-stimulating hormone FSHR ). Epigenetic changes are believed to contribute PCOS-related The impact adipokines inflammation has been discussed, with such as fat mass FTO ) melanocortin-4-receptor MC4R playing significant roles. affecting sperm quality function, including nuclear subfamily 3 group C member 1 NR3C1 methylenetetrahydrofolate reductase MTHFR have investigated males. Hormonal dysregulation influenced by genetic markers, leptin LEPR tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), was also examined. vital Genes involved metabolism, hormonal regulation, association further complicate relationship. Understanding these is address develop personalized interventions.

Язык: Английский

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