Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(7), С. 1980 - 1980
Опубликована: Март 29, 2024
Background:
Atopic
Dermatitis
(AD)
is
a
prevalent
inflammatory
skin
disease
whose
course
often
complicated
by
the
presence
of
concomitant
anxiety
and
depressive
disorders.
Dupilumab
has
been
demonstrated
to
be
largely
effective
in
AD.
The
aims
present
study
were
(1)
verify
effectiveness
2-year
dupilumab
treatment
on
symptoms
patients
affected
AD
(2)
identify
predictors
persistence
psychiatric
despite
maintenance
with
dupilumab.
Methods:
A
total
331
severe
assessed
at
baseline
different
times
over
2
years
large
set
rating
scales,
including
Eczema
Area
Severity
Index
(EASI),
Hospital
Anxiety
Depression
Scale
(HADS),
Dermatology
Life
Quality
(DLQI).
Paired
sample
t-tests
performed
severity
mental
health
items.
Two
binary
logistic
regression
models
then
used
clinically
significant
depression
anxiety,
defined
score
≥
8
each
sub-scale
HADS.
Results:
After
dupilumab,
benefited,
showing
improvement
both
dermatological
comorbid
depression/anxiety
(p
<
0.001
for
all
scales).
Overall,
17.5%
13%
patients,
respectively,
reported
residual
after
found
higher
body
mass
index
(BMI)
=
0.012),
lower
impact
quality
life
0.015),
more
0.01),
while
only
predictor
was
female
gender
0.03).
Conclusions:
Using
multidisciplinary
approach,
baseline,
dermatologists
should
closely
monitor
who
are
greater
risk
maintaining
therapy,
such
as
those
overweight.
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(4), С. 136 - 136
Опубликована: Апрель 2, 2024
Alzheimer's
disease
(AD)
is
an
age-related
progressive
neurodegenerative
disorder
characterized
by
aberrant
amyloid
precursor
protein
(APP)
cleavage,
pathological
aggregations
of
beta-amyloid
(Aβ)
that
make
up
Aβ
plaques
and
hyperphosphorylation
Tau
makes
neurofibrillary
tangles
(NFTs).
Although
progress
has
been
made
in
research
on
AD,
the
fundamental
causes
this
have
not
fully
elucidated.
Recent
studies
shown
vascular
dysfunction
especially
loss
pericytes
plays
a
significant
role
onset
AD.
Pericytes
play
variety
important
roles
nervous
system
including
regulation
cerebral
blood
flow
(CBF),
formation
maintenance
blood–brain
barrier
(BBB),
angiogenesis,
clearance
toxic
substances
from
brain.
participate
transport
through
various
receptors,
acts
to
cause
them
constrict,
detach,
die.
The
elevates
levels
Aβ1-40
Aβ1-42
disrupting
integrity
BBB
reducing
soluble
brain
interstitial
fluid.
aggravated
deposition
further
exacerbates
pericyte
dysfunction,
forming
vicious
cycle.
combined
influence
these
factors
eventually
results
neurons
cognitive
decline.
Further
exploration
interactions
between
beneficial
for
understanding
AD
could
lead
identification
new
therapeutic
targets
prevention
treatment
In
review,
we
explore
characterization
pericytes,
other
cells
neurovascular
unit
(NVU),
physiological
functions
dysfunctions
This
review
discusses
Aβ,
as
well
current
strategies
preventing
or
treating
targeting
pericytes.
Nutrients,
Год журнала:
2024,
Номер
16(20), С. 3570 - 3570
Опубликована: Окт. 21, 2024
Recent
research
highlights
the
growing
interest
in
impact
of
nutrition
on
cognitive
health
and
function
disease,
as
dietary
habits
are
increasingly
recognized
crucial
factors
relation
to
brain
function.
This
focus
is
especially
important
given
rising
prevalence
neurodegenerative
diseases
decline
associated
with
poor
choices.
Links
now
being
sought
between
microbiota
gut-brain
axis.
Mechanisms
proposed
that
include
low-grade
chronic
neuroinflammation,
influence
short-chain
fatty
acids,
or
disruption
glial
cells
transmitters
brain.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Processed
foods
are
that
undergo
physical,
chemical,
or
biological
processes
to
enhance
durability,
extend
shelf
life,
improve
taste
and
texture,
alter
nutritional
content,
facilitate
consumption.
While
traditional
processed
preserved
packaged
through
methods
such
as
canning
salting,
ultra-processed
(UPFs)
industrially
produced
formulations
ready-to-eat
ready-to-heat
typically
contain
little
no
whole
food
ingredients.
Recent
evidence
suggests
the
adverse
health
effects
of
UPFs
may
not
only
be
due
nutrients
they
provide
but
also
non-nutritive
components
their
impact
on
gut
health.
Diets
rich
in
associated
with
cellular
changes
leading
oxidative
stress,
which
turn
contributes
inflammation
aging
processes.
In
this
context,
reducing
consumption
UPFs,
limiting
refined
carbohydrates,
modifying
meal
timing
frequency
recommended
for
improving
npj Metabolic Health and Disease,
Год журнала:
2025,
Номер
3(1)
Опубликована: Апрель 8, 2025
Consumption
of
ultra-processed
foods
(UPFs)
increases
overall
caloric
intake
and
is
associated
with
obesity,
cardiovascular
disease,
brain
pathology.
There
scant
evidence
as
to
why
UPF
consumption
leads
increased
whether
the
negative
health
consequences
are
due
adiposity
or
characteristics
UPFs.
Using
UK
Biobank
sample,
we
probed
associations
between
consumption,
adiposity,
metabolism,
structure.
Our
analysis
reveals
that
high
linked
adverse
metabolic
profiles,
alongside
cellularity
changes
in
feeding-related
subcortical
areas.
These
partially
mediated
by
dyslipidemia,
systemic
inflammation
body
mass
index,
suggesting
UPFs
exert
effects
on
beyond
just
contributing
obesity.
This
dysregulation
network
structures
may
create
a
self-reinforcing
cycle
consumption.
Foods,
Год журнала:
2025,
Номер
14(8), С. 1357 - 1357
Опубликована: Апрель 15, 2025
It
is
now
known
that
diet
or
food
one
of
the
environmental
factors
can
induce
contribute
to
autoimmunity.
In
a
healthy
person
with
normal
functioning
immune
system,
substances
encounter
no
resistance
and
are
allowed
passage
through
barriers
without
triggering
reactivity.
However,
clinicians
becoming
increasingly
aware
modern
food-processing
methods
increase
decrease
reactivity
foods,
including
allergic
reactions.
Immune
reactions
undigested
antigens
could
result
in
production
IgE
antibodies,
which
involved
immediate
reactivity,
IgG
IgA
delayed
Currently,
measurements
these
antibodies
generally
only
performed
against
derived
from
raw
foods.
testing
for
based
on
consumption
inaccurate
because
people
eat
both
cooked
Even
home-cooked
foods
undergo
different
kinds
preparation
processing.
Food
processing
change
structure
materials
into
secondary,
tertiary,
quaternary
structures
have
reactive
properties.
This
affect
body’s
oral
tolerance
food,
causing
system
mistakenly
identify
as
harmful
foreign
substance
react
it
immunologically,
leading
abnormal
reaction
molecules
lead
not
just
target
but
also
own
tissues,
significant
implications
autoimmunity
induction
due
cross-reactivity
other
mechanisms
discussed
here.
We
hope
this
present
review
will
stimulate
further
research
role
modified
some
all
key
points
review.
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 1053 - 1053
Опубликована: Апрель 4, 2024
Objective:
The
aim
of
this
study
was
to
examine
the
relationship
ultra-processed
food
(UPF)
intake
with
incidence
glaucoma
in
a
large
sample
Spanish
university
graduates
followed
prospectively.
Methods:
Prospective
cohort
using
data
from
SUN
Project.
A
final
19,225
participants
(60.1%
women)
included
study,
mean
age
38.2
years
(standard
deviation
(SD)
=
12.4).
Participants
were
followed-up
for
time
12.9
(SD
5.4).
Dietary
measured
136-item
semiquantitative
food-frequency
questionnaire.
UPFs
defined
based
on
NOVA
classification
system.
Glaucoma
diagnosis
determined
by
asking
if
they
had
ever
been
diagnosed
an
ophthalmologist.
This
self-reported
has
previously
validated.
Results:
After
adjusting
several
covariates,
highest
UPF
consumption
at
higher
risk
(hazard
ratio
(HR)
1.83;
95%
confidence
interval
(CI)
1.06
3.17)
when
compared
lowest
category
consumption.
Regarding
subgroup
analyses,
significant
multiplicative
interaction
found
(p
0.004)
and
omega
3:6
0.040).
However,
association
between
only
older
(aged
≥
55
years),
men,
most
physically
active
group,
group
non-
or
former
smokers,
those
lower
ratio,
energy
intake.
contribution
each
type
coming
sweets
showed
risky
effect
(HR
1.51;
CI
1.07
2.12).
Conclusions:
prospective
shows
that
greater
have
developing
Our
findings
emphasize
relevance
monitoring
limiting
as
means
preventing
incidence.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
272, С. 132859 - 132859
Опубликована: Июнь 1, 2024
Methylglyoxal
(MGO),
a
highly
reactive
precursor
of
advanced
glycation
end
products,
is
endogenously
produced
and
prevalent
in
various
food
products.
This
study
aimed
to
characterize
protein
modifications
SH-SY5Y
human
neuroblastoma
cells
induced
by
MGO
identify
potential
biomarkers
for
its
exposure
toxicity.
A
shot-gun
proteomic
analysis
was
applied
treated
with
without
exogenous
MGO.
Seventy-seven
proteins
were
identified
as
susceptible
modification,
among
which
eight,
including
vimentin
histone
H2B
type
2-F,
showing
concentration-dependent
externally
added
MGO,
defined
exposure.
Remarkably,
up
10
modification
sites
on
vimentin.
Myosin
light
polypeptide
6
emerged
biomarker
toxicity,
exclusively
observed
under
cytotoxic
levels.
Additionally,
like
serine/threonine-protein
kinase
SIK2
calcyphosin,
exhibiting
comparable
or
even
higher
levels
control
compared
MGO-treated
cells,
endogenous
Bioinformatics
revealed
that
motor
proteins,
cytoskeleton
components,
glycolysis
overrepresented
those
modification.
These
results
both
provide
insights
into
the
cellular
effects
formed
versus
