Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection

Molecules, Год журнала: 2023, Номер 28(14), С. 5415 - 5415

Опубликована: Июль 14, 2023

The increase in people’s longevity has, consequently, led to more brain involvement and neurodegenerative diseases, which can become complicated lead chronic degenerative thereby presenting greater public health problems. Medicinal plants have been used since ancient times contain high concentrations of molecules, including polyphenols. It has proven that polyphenols, are present various natural sources provide curative effects against diseases disorders through neuroprotective effects. These mainly attributed their ability cross the blood–brain barrier, eliminate reactive oxygen species, cause chelation metal ions. Polyphenols concentration neurotrophic factors bind directly membrane receptors these factors, modulate activate signaling cascades allow plasticity, survival, proliferation, growth neuronal cells, allowing for better learning, memory, cognition. Moreover, polyphenols no serious adverse side resulting from consumption.

Язык: Английский

---

Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114993 - 114993

Опубликована: Июнь 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Язык: Английский

---

Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Journal of Molecular Medicine, Год журнала: 2023, Номер 101(5), С. 501 - 526

Опубликована: Апрель 4, 2023

Язык: Английский

---

A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson’s Disease

Pharmaceuticals, Год журнала: 2023, Номер 16(7), С. 908 - 908

Опубликована: Июнь 21, 2023

The neurodegenerative condition known as Parkinson’s disease (PD) is brought on by the depletion of dopaminergic neurons in basal ganglia, which brain region that controls body movement. PD occurs due to many factors, from one acknowledged effects oxidative stress pathogenic pathways play a role development disease. Antioxidants, including flavonoids, vitamins E and C, polyphenolic substances, help reduce free radicals. Consequently, this lowers risk disorders long term. Although there currently no cure for illnesses, these conditions can be controlled. treatment lessens its symptoms, helps preserve patient’s quality life. Therefore, use naturally occurring antioxidants, such polyphenols, may obtained through food or nutritional supplements have variety positive effects, has emerged an appealing alternative management strategy. This article will examine extent knowledge about antioxidants well future directions research. Additionally, evaluation value neuroprotective agents provided.

Язык: Английский

---

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 692 - 692

Опубликована: Май 27, 2024

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.

Язык: Английский

---

Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies

Foods, Год журнала: 2025, Номер 14(2), С. 176 - 176

Опубликована: Янв. 8, 2025

Antioxidants are widely recognized for their potential health benefits, including impact on cognitive function and gut microbiome modulation. Understanding these effects is essential exploring broader clinical applications. This review aims to evaluate the of antioxidants function, with a focus findings from randomized controlled trials (RCTs). The studies involved human participants across range age groups, interventions encompassing natural antioxidant sources, such as berries, well specific vitamins. An extensive search PubMed, SCOPUS, Web Science databases identified six relevant RCTs, each evaluated bias. These focused variety antioxidant-rich products, both naturally derived sources supplemental forms. Antioxidants, vitamins C, B2, D, along polyphenols xanthohumol, fermented papaya, peanuts, berry extracts, demonstrate support promote through mechanisms that modulate diversity reduce inflammation. However, observed changes in were modest inconsistent studies. While preliminary evidence suggests may benefit heterogeneity existing limits immediate applicability. Additionally, more robust RCTs needed substantiate guide future interventions.

Язык: Английский

---

Psychobiotics and the Microbiota–Gut–Brain Axis: Where Do We Go from Here?

Microorganisms, Год журнала: 2024, Номер 12(4), С. 634 - 634

Опубликована: Март 22, 2024

The bidirectional relationship between the gut microbiota and nervous system is known as microbiota-gut-brain axis (MGBA). MGBA controls complex interactions brain, enteric system, gut-associated immune neuroendocrine systems, regulating key physiological functions such response, sleep, emotions mood, food intake, intestinal functions. Psychobiotics are considered tools with potential to modulate through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects health yet be characterized. This narrative review perspectives article highlights paradigms needing attention scope probiotics applications in human increases, a growing body evidence supporting systemic beneficial effects. However, there limitations overcome before establishing extent which we can incorporate management neuropsychiatric disorders. Although this uses term general manner, it remains important study at strain level most cases.

Язык: Английский

---

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Nutrients, Год журнала: 2024, Номер 16(10), С. 1500 - 1500

Опубликована: Май 16, 2024

As the population ages, incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted importance gut microbial homeostasis its impact on brain functions, commonly referred as gut–brain axis, in maintaining overall health wellbeing. Nonetheless, mechanisms by which system acts remains poorly defined. In review, we will explore how (poly)phenols, a class natural compounds found many plant-based foods beverages, can modulate thereby promote neural health. While evidence indicates beneficial role (poly)phenol consumption part balanced diet, human scarce mechanistic insight still lacking. regard, make case that dietary (poly)phenols should be further explored establish their therapeutic efficacy through modulation with much greater emphasis carefully designed interventions.

Язык: Английский

---

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and treatments past decade; however, complexity heterogeneity certain breast subtypes often lead to drug resistance metastatic progression. Owing their low toxicity high variety, natural products derivatives are becoming increasingly valuable sources for small‐molecule anticancer drugs. Polyphenols more widely known role prevention as adjuvants conventional treatment strategies. Therefore, this review focuses on antitumor effects curcumin, resveratrol, polydatin cancer. According main databases, only vitro preclinical studies with solid scientific backgrounds reports protective were included. Curcumin, antioxidant, anti‐inflammatory, effects; indeed, they improve efficacy; reduce chemoresistance, angiogenesis, tumor growth; induce apoptosis, autophagy, cell cycle arrest through multiple molecular pathways, including suppression epithelial–mesenchymal transition (EMT), NF‐κB, PI3K/Akt/mTOR, c‐Jun N‐terminal kinase (JNK), MAPK, ERK1/2, STAT signaling pathways; inhibition cyclins matrix metalloproteinase (MMP)‐2 MMP‐9; activation p53 microtubule‐associated protein light chain 3 (LC3).

Язык: Английский

---

Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1062 - 1062

Опубликована: Авг. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Язык: Английский

---