Association between Controlling Nutritional Status (CONUT) Score and Body Composition, Inflammation and Frailty in Hospitalized Elderly Patients

Nutrients, Год журнала: 2024, Номер 16(5), С. 576 - 576

Опубликована: Фев. 20, 2024

The Controlling Nutritional Status (CONUT) score has demonstrated its ability to identify patients with poor nutritional status and predict various clinical outcomes. Our objective was assess the association between CONUT score, inflammatory status, body composition, as well at risk of frailty in hospitalized elderly patients. Methods: a total 361 were retrospectively recruited divided into three groups based on score. Results: ≥5 exhibited significantly higher levels markers, such erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Neutrophil/Lymphocytes ratio (NLR), main platelet volume (MPV), ferritin, compared those lower Furthermore, these showed unfavorable changes including percentage skeletal muscle mass (MM) fat-free (FFM) fatty (FM). A positive correlation found Geriatric Depression Scale Short Form (GDS-SF), FM. Conversely, Mini Assessment (MNA), Mini-Mental Examination, activity daily living (ADL), instrumental (IADL), Barthel index, FFM, MM negative correlation. Frailty highly prevalent among receiver operating characteristic (ROC) curve high accuracy identifying frail (sensitivity). Conclusions: is associated pro-inflammatory composition. Additionally, it good tool

Язык: Английский

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Relationship between prognostic nutritional index and post-stroke cognitive impairment

Nutritional Neuroscience, Год журнала: 2024, Номер 27(11), С. 1330 - 1340

Опубликована: Апрель 2, 2024

Background The Prognostic Nutritional Index (PNI) has been described as a useful screening tool for patient prognosis in several diseases. As potential diagnostic index, it attracted the interest of many physicians. However, correlation between PNI and post-stroke cognitive impairment (PSCI) remains unclear.

Язык: Английский

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Molecular Assessment of Methylglyoxal-Induced Toxicity and Therapeutic Approaches in Various Diseases: Exploring the Interplay with the Glyoxalase System

Life, Год журнала: 2024, Номер 14(2), С. 263 - 263

Опубликована: Фев. 17, 2024

This comprehensive exploration delves into the intricate interplay of methylglyoxal (MG) and glyoxalase 1 (GLO I) in various physiological pathological contexts. The linchpin narrative revolves around role these small molecules age-related issues, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders. Methylglyoxal, a reactive dicarbonyl metabolite, takes center stage, becoming principal player development AGEs contributing to cell tissue dysfunction. dual facets GLO I-activation inhibition-unfold as potential therapeutic avenues. Activators, spanning synthetic drugs like candesartan natural compounds polyphenols isothiocyanates, aim restore I function. These molecular enhancers showcase promising outcomes conditions such diabetic retinopathy, kidney disease, beyond. On contrary, inhibitors emerge crucial players cancer treatment, offering new possibilities diseases associated with inflammation multidrug resistance. symphony molecules, from activators inhibitors, presents nuanced understanding MG regulation. From drugs, each element contributes orchestra, novel interventions personalized approaches pursuit health wellbeing. abstract concludes an emphasis on necessity rigorous clinical trials validate findings acknowledges importance individual variability complex landscape health.

Язык: Английский

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Post-Stroke Rehabilitation: Challenges and New Perspectives

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(2), С. 550 - 550

Опубликована: Янв. 10, 2023

A stroke is determined by insufficient blood supply to the brain due vessel occlusion (ischemic stroke) or rupture (hemorrhagic stroke), resulting in immediate neurological impairment differing degrees [...].

Язык: Английский

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Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2551 - 2551

Опубликована: Сен. 17, 2023

Emerging science continues to establish the detrimental effects of malnutrition in acute neurological diseases such as traumatic brain injury, stroke, status epilepticus and anoxic injury. The primary pathological pathways responsible for secondary injury include neuroinflammation, catabolism, immune suppression metabolic failure, these are exacerbated by malnutrition. Given this, there is growing interest novel nutritional interventions promote recovery after In this review, we will describe how impacts biomolecular mechanisms disorders, can be optimized both pediatric adult populations. We further highlight emerging therapeutic approaches, including specialized diets that aim resolve immunodeficiency crisis, providing pre-clinical clinical evidence their use promotes neurologic recovery. Using nutrition a targeted treatment appealing several reasons discussed. high mortality short- long-term morbidity associated with injuries, translational approaches needed.

Язык: Английский

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Prognostic implications of the arginine metabolism in patients at nutritional risk: A secondary analysis of the randomized EFFORT trial

Clinical Nutrition, Год журнала: 2024, Номер 43(3), С. 660 - 673

Опубликована: Янв. 22, 2024

Язык: Английский

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Association Between TCBI (Triglycerides, Total Cholesterol, and Body Weight Index) and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients

Clinical Interventions in Aging, Год журнала: 2024, Номер Volume 19, С. 1091 - 1101

Опубликована: Июнь 1, 2024

Purpose: Stroke-associated pneumonia (SAP) usually complicates stroke and is linked to adverse prognoses. Triglycerides, total cholesterol, body weight index (TCBI) a new simple calculated nutrition index. This study seeks investigate the association between TCBI SAP incidence, along with its predictive value. Patients Methods: Nine hundred sixty-two patients acute ischemic were divided into group Non-SAP group. The was three layers: T1, < 948.33; T2, 948.33– 1647.15; T3, > 1647.15. Binary Logistic regression analysis used determine relationship levels incidence of SAP. Furthermore, restricted cubic splines (RCS) utilized evaluate influence on risk Results: in markedly lower compared that ( P 0.001). model revealed that, using T3 layer as reference, T1 had highest for prevalence (OR = 2.962, 95% CI: 1.600– 5.485, 0.001), confounding factors being controlled. RCS found linear nonlinear 0.490, overall 0.004). Moreover, incorporating A 2 DS (Age, atrial fibrillation, dysphagia, sex, severity) substantially enhanced initial model's accuracy. Conclusion: Low associated higher In clinical practice, has shown value SAP, contributing early intervention treatment Keywords: stroke, stroke-associated pneumonia, nutritional status,

Язык: Английский

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Analysis of the Impact of Muscle Mass Changes in Stroke Patients

Pharmacognosy Journal, Год журнала: 2025, Номер 16(6), С. 1359 - 1364

Опубликована: Янв. 1, 2025

Stroke has become an increasingly prevalent health issue every year. Malnutrition is one of the complications that arise in post-stroke patients. Reduced physical activity, intake disturbances, and comorbidities experienced by stroke patients can trigger malnutrition. Additionally, factors such as age, sex, Body Mass Index (BMI), type accelerate onset One signs malnutrition a change body composition, characterized muscle mass loss due to inflammatory responses catabolic reactions, which lead increased caloric needs This study aims investigate changes at Dr. Kariadi General Hospital, Semarang, Central Java, Indonesia. observational with cross sectional design conducted Hospital from November 2023 April 2024. The sample size was 49 diagnosed stroke, receiving medical care on first day Hospital. evaluates type, BMI, smoking habits, diabetes mellitus, dyslipidemia, hyperuricemia, hypertension, kidney disorders, respiratory diseases, relation fat-free mass, fat visceral fat, phase angle, assess correlation changes. Data analysis will be approached using Structural Equation Modeling (SEM) Partial Least Square (PLS). results show various risk affect composition changes, contributing up 84.1%. In conclusion, decline influenced factors, addition reductions indicate tendency toward risk.

Язык: Английский

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Influence of nutritional status on rehabilitation efficacy of patients after stroke—a scoping review

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

Stroke patients are susceptible to malnutrition as a result of dysphagia, neurological impairments, and altered levels consciousness. The nutritional status individuals post-stroke is critical determinant influencing the efficacy rehabilitation outcomes. Therefore, there great interest in possible role nutrients promoting recovery after stroke. This article examines enhancement outcomes through improvement status. A comprehensive literature search was conducted using PubMed, Cochrane, Web Science, Embase databases. Articles relevant this topic, published from inception each database until November 2024, were identified. selection restricted randomized controlled clinical trials, irrespective language or publication date. specifically targeted studies involving stroke patients, encompassing both hemorrhagic ischemic types, interventions that combined supplementation with therapy. Studies focus on prevention excluded. Full-text articles met inclusion criteria retrieved aforementioned sources. In instances where full report conference abstract available for same study, only considered. total 751 considered scoping review. Following rigorous screening process, 13 selected detailed analysis. All trials. findings indicate such proteins, vitamins, essential amino acids, antioxidants can enhance activities daily living, improve balance function, reduce deficits patients. review aims synthesize current evidence regarding effects various dietary regimens limb goal providing new insights facilitate accelerated population.

Язык: Английский

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Association of a novel nutritional index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from the China Health and Retirement Longitudinal Study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 3, 2025

Purpose The triglyceride-cholesterol-body weight index (TCBI), a novel and easily computable nutritional index, incorporates serum triglyceride (TG), total cholesterol (TC), body (BW). This study explored the association between TCBI cognitive impairment in middle-aged elderly Chinese populations. Patients methods cross-sectional employed data from China Health Retirement Longitudinal Study (CHARLS) baseline survey, including 7,145 participants. was calculated as TG (mg/dL) × TC BW (kg)/1,000. Cognitive function assessed based on mental status episodic memory, with score below 11 indicating impairment. relationship examined using multiple logistic regression, smooth curve fitting, subgroup analyses. Results After full adjustment, each 1-unit increase log-transformed (Lg TCBI) associated 29.7% reduction risk [odds ratio (OR) = 0.703, 95% confidence interval (CI): 0.529–0.933; p 0.015]. When Lg categorized into quartiles, Q2, Q3, Q4 groups exhibited reduced of by 19.9, 16.3, 22.9%, respectively ( for trend 0.043), compared to Q1 group. Smooth fitting revealed consistent decrease higher levels. Subgroup analysis indicated that stronger among participants aged ≥60 years (OR 0.655, CI: 0.438–0.979), non-current drinkers 0.643, 0.451–0.917), those who engaged socializing 0.568, 0.371–0.871). Conclusion significantly negatively individuals, effect more pronounced years, drinkers, socially active

Язык: Английский

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