In vitro evaluation of the immunomodulatory activity of the nutraceutical formulation AminoDefence DOI Creative Commons
Bianca Papotti, M. Dessena, Maria Pia Adorni

и другие.

International Journal of Food Sciences and Nutrition, Год журнала: 2023, Номер 75(2), С. 173 - 184

Опубликована: Ноя. 29, 2023

Immune system (IS) functionality is warranted by inter-dependent processes that balance body defences without exceeding in inflammation. An ideal nutraceutical approach should sustain the protective IS activity while controlling The potential immunomodulatory of food supplement (FS) AminoDefence was studied resting macrophages RAW264.7 and following stimulation bacterial- viral-associated inflammation trough LPS PolyI:C treatments, respectively. In unstimulated macrophages, formulation exerted a dose-dependent immunostimulant up-regulating NO, IL-6, TNF-α MCP-1 release, it dampened aberrant release these factors induced pro-inflammatory stimuli. Exploring contribution single components Echinacea purpurea (E. purpurea) extract quercetin, used at proportional concentrations than whole formulation, more pronounced effect observed for E. purpurea, an anti-inflammatory quercetin. Hence, exerts effectively stimulating inflammatory response limiting cases excessive

Язык: Английский

In vitro evaluation of the immunomodulatory activity of the nutraceutical formulation AminoDefence DOI Creative Commons
Bianca Papotti, M. Dessena, Maria Pia Adorni

и другие.

International Journal of Food Sciences and Nutrition, Год журнала: 2023, Номер 75(2), С. 173 - 184

Опубликована: Ноя. 29, 2023

Immune system (IS) functionality is warranted by inter-dependent processes that balance body defences without exceeding in inflammation. An ideal nutraceutical approach should sustain the protective IS activity while controlling The potential immunomodulatory of food supplement (FS) AminoDefence was studied resting macrophages RAW264.7 and following stimulation bacterial- viral-associated inflammation trough LPS PolyI:C treatments, respectively. In unstimulated macrophages, formulation exerted a dose-dependent immunostimulant up-regulating NO, IL-6, TNF-α MCP-1 release, it dampened aberrant release these factors induced pro-inflammatory stimuli. Exploring contribution single components Echinacea purpurea (E. purpurea) extract quercetin, used at proportional concentrations than whole formulation, more pronounced effect observed for E. purpurea, an anti-inflammatory quercetin. Hence, exerts effectively stimulating inflammatory response limiting cases excessive

Язык: Английский

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