Bifidobacterium breve Probiotic Compared to Lactobacillus casei Causes a Better Reduction in Demyelination and Oxidative Stress in Cuprizone-Induced Demyelination Model of Rat
Molecular Neurobiology,
Год журнала:
2023,
Номер
61(1), С. 498 - 509
Опубликована: Авг. 28, 2023
Язык: Английский
Milk and multiple sclerosis: A possible link?
Multiple Sclerosis and Related Disorders,
Год журнала:
2024,
Номер
83, С. 105477 - 105477
Опубликована: Янв. 28, 2024
Язык: Английский
A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders
Vaccines,
Год журнала:
2023,
Номер
11(6), С. 1031 - 1031
Опубликована: Май 27, 2023
Oral
immune
tolerance
is
a
physiological
process
to
achieve
against
autoimmunity
by
oral
ingestion
of
self-antigen(s)
or
other
therapeutics.
At
the
cellular
level,
suppresses
autoimmune
diseases
activating
FoxP-positive
and
-negative
regulatory
T
cells
(Tregs)
and/or
causing
clonal
anergy
deletion
autoreactive
cells,
affecting
B
cell
tolerance.
However,
delivery
antigens/biologics
challenging
due
their
instability
in
harsh
environment
gastrointestinal
(GI)
tract.
Several
antigen/drug
tools
approaches,
including
micro/nanoparticles
transgenic
plant-based
systems,
have
been
explored
demonstrate
for
different
successfully.
despite
effectiveness,
variation
results,
dose
optimization,
undesirable
system
activation
are
limitations
approach
further
advancement.
From
this
perspective,
current
review
discusses
phenomenon,
mechanisms,
antigen
strategies,
its
challenges.
Язык: Английский
Unleashing the potential: Camel Milk and Urine Research insights for performance, collaboration, structure and future trends (1947–2023)
Cogent Food & Agriculture,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 6, 2024
Research
on
camel
milk
and
urine
(CMUR)
has
gained
significant
attention
because
of
its
nutritional
medicinal
applications.
The
aim
this
study
was
to
conduct
a
bibliometric
analysis
the
CMUR
from
1947
2023.
Following
PRISMA
rules,
Scopus
database
used
extract
1338
English-language
studies,
which
were
analyzed
using
Analytics,
Bibliometrix,
VOSviewer.
findings
indicated
that
7.78%
studies
focused
within
domain.
showed
steady
increase
in
number
publications
over
77
years
(R-squared
=
0.8308).
encompasses
wide
range
research
disciplines,
with
particular
emphasis
agricultural
medical
fields.
Saudi
Arabia
is
top
producer
CMUR,
Journal
Camel
Practice
being
most
prolific
source.
King
Saud
University
contributed
103
documents
making
it
institution
globally.
co-word
identified
seven
prominent
themes
can
be
further
categorized
into
four
distinct
clusters.
Notably,
'Probiotics',
'Anti-inflammatory',
'Diabetes'
emerged
as
trending
subjects.
yielded
insights
present
trends,
gaps
existing
knowledge,
provided
valuable
recommendations
for
future
investigations.
Язык: Английский
Propionic Acid Impact on Multiple Sclerosis: Evidence and Challenges
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3887 - 3887
Опубликована: Ноя. 14, 2024
Accumulating
evidence
suggests
that
multiple
sclerosis
(MS)
is
an
environmentally
influenced
disorder
with
contributions
from
life-time
exposure
to
factors
including
Epstein–Barr
virus
infection
or
shifts
in
microbiome,
diet
and
lifestyle.
One
suggested
factor
a
deficiency
propionic
acid,
short-chain
fatty
acid
produced
by
gut
bacteria
may
contribute
the
disease
pathology
both
animal
models
human
cases
of
MS.
Propionate
appears
exert
beneficial
effects
on
immune,
peripheral
central
nervous
systems
people
MS
(pwMS),
showing
immunoregulatory,
neuroprotective
neurogenerative
effects.
These
functions
are
crucial,
given
characterized
immune-mediated
damage
myelin
system.
Accordingly,
propionate
supplementation
modulated
increase
its
levels
through
microbiome
help
counteract
pro-inflammatory
state
directly
regulating
immune
system
and/or
decreasing
permeability
barrier
blood–brain
barrier.
This
could
potentially
improve
outcomes
when
used
immune-modulating
therapy.
However,
while
broad
promising,
further
large
clinical
trials
necessary
evaluate
efficacy
safety
pwMS
clarify
role
as
complementary
therapeutic
strategy.
review
provides
comprehensive
analysis
evidence,
challenges
limitations
concerning
Язык: Английский
The Halotolerant Probiotic Bacterium Enterococcus lactis ASF-2 from Al-Asfar Lake, Saudi Arabia, Reduces Inflammation in Carrageenan-Induced Paw Edema
Najla Bint Saud Al-Saud,
Amjad Abdul Hamid Almajed,
Allujayn Lwusaybie
и другие.
Microorganisms,
Год журнала:
2023,
Номер
11(10), С. 2415 - 2415
Опубликована: Сен. 27, 2023
Inflammation-related
diseases
are
major
causes
of
mortality
and
disability
worldwide.
This
study
aimed
to
identify
investigate
probiotic
bacteria
that
could
be
present
in
Al-Asfar
Lake
Al-Ahsa
City,
Saudi
Arabia
prevent
the
inflammatory
responses
carrageenan-induced
paw
edema.
In
total,
seven
active
strains
were
isolated,
three
isolates
(ASF-1,
ASF-2,
ASF-3)
exhibited
a
positive
Gram
stain
viable
growth
at
20%
NaCl
salinity;
they
also
lacked
catalase
hemolytic
activities
had
high
levels
cell
surface
hydrophobicity
(CSH).
They
demonstrated
potent
antibacterial
activity
against
Salmonella
typhi
Staphylococcus
aureus.
These
results
revealed
ASF-2
qualities,
it
was
selected
for
further
research.
significant
anti-inflammatory
effects
an
experimental
model
edema;
showed
decreased
pro-inflammatory
markers,
such
as
interleukin
6
(IL-6),
17
(IL-17),
transforming
factor-β
(TGF-β),
increased
level
marker
(interferon
gamma
(IFN-γ)).
Animals
control
group
saw
45%
decrease
edema
when
compared
mice
carrageenan
group.
When
comparing
tissue
damage
infiltration
ASF-2-treated
non-treated
mice,
histological
examination
sub-planar
tissues
hind
leg
inflamed
healed.
The
16S
rRNA
sequencing
method
utilized
establish
is,
fact,
Enterococcus
lactis
with
99.2%
sequence
similarity.
findings
shed
light
on
ASF-2’s
potential
biocompatible
medication.
Язык: Английский
Bacillus subtilis PM5 from Camel Milk Boosts Chicken Immunity and Abrogates Salmonella entertitidis Infections
Microorganisms,
Год журнала:
2023,
Номер
11(7), С. 1719 - 1719
Опубликована: Июнь 30, 2023
With
the
practice
of
a
successful
livestock
industry
using
antibiotics,
which
has
continued
for
more
than
five
decades,
researchers
have
long
been
interested
in
finding
alternatives
to
antibiotics
poultry
production.
Probiotics
can
potentially
reduce
enteric
diseases
and
enhance
their
productivity.
The
aim
this
study
was
isolate
putative
probiotics
from
camel
milk
test
them
against
Salmonella
infection
as
well
host
immune
development.
Thirteen
different
isolates
were
obtained
six
samples
dairy
farms
Saudi
Arabia.
Three
(PM1,
PM2,
PM3,
PM4,
PM5,
PM6)
that
showed
Gram-positive
characters
reacted
negatively
catalase
hemolytic
assays.
PM1,
PM6
significant
nonpolar
surface
properties
(>51%
hydrophobic)
potent
antimicrobial
activities
avian
pathogens,
namely
S.
enterica,
typhi,
aureus,
E.
coli.
PM5
exhibited
substantial
probiotic
traits;
therefore,
further
focus
given
it.
identified
Bacillus
subtilis
OQ913924
by
16S
rRNA
sequencing
method
similarity
matrix
>
99%.
An
vivo
chicken
model
used
access
health
benefits
probiotics.
After
salmonella
infection,
mucosal
response
significantly
increased
(p
<
0.01),
none
challenge
protocols
caused
mortality
or
clinical
symptoms
after
intestinal
contents.
enterica
organ
infiltration
spleen,
thymus,
small
intestine
reduced
B.
PM5-fed
chickens.
load
feces
CFU
7.2
5.2
oral-fed
Probiotic-fed
chickens
buffered
content
positively
regulated
level
butyric
acid
0.05),
interleukin
1
beta
(IL1-β),
C-reactive
protein
(CRP),
interferon
gamma
(IFN-γ)
levels
0.05).
In
addition,
binding
peritoneal
macrophages
cells
inhibited
adhesion,
indicating
co-aggregation
macrophage
cells.
It
could
be
concluded
supplementation
with
improve
growth
performance
broilers
quality
broiler
pathogens.
introduction
into
commercial
feed
market
near
future
may
assist
narrowing
gap
now
exists
between
breeding
consumer
demand.
Язык: Английский
Bacterial live therapeutics for human diseases
Molecular Systems Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Язык: Английский
Probiotic and Rice-Derived Compound Combination Mitigates Colitis Severity
Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1463 - 1463
Опубликована: Окт. 31, 2024
This
study
investigated
the
ability
of
Язык: Английский
Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3
Medicina,
Год журнала:
2023,
Номер
59(10), С. 1731 - 1731
Опубликована: Сен. 27, 2023
Background
and
Objectives:
Milk
is
healthy
includes
several
vital
nutrients
microbiomes.
Probiotics
in
milk
their
derivatives
modulate
the
immune
system,
fight
inflammation,
protect
against
numerous
diseases.
The
present
study
aimed
to
isolate
novel
bacterial
species
with
probiotic
potential
for
neuroinflammation.
Materials
Methods:
Six
samples
were
collected
from
lactating
dairy
cows.
Bacterial
isolates
obtained
using
standard
methods
evaluated
based
on
characteristics
such
as
catalase
test,
hemolysis,
acid/bile
tolerance,
cell
adhesion,
hydrophobicity,
well
vitro
screening.
Results:
Nine
morphologically
diverse
found
six
different
types
of
cow's
milk.
Among
isolates,
PO3
displayed
characteristics.
was
a
Gram-positive
rod
that
grew
an
acidic
(pH-2)
salty
medium
containing
bile
salt
salinity
(8%
NaCl).
also
exhibited
substantial
hydrophobicity
adhesion.
sequencing
comparison
16S
rRNA
genes
revealed
Lactococcus
raffinolactis
similarity
score
99.3%.
Furthermore,
assessed
its
neuroanti-inflammatory
activity
human
oligodendrocyte
(HOG)
lines
four
neuroimmune
markers:
signal
transducer
activator
transcription
(STAT-3),
myelin
basic
protein
(MBP),
glial
fibrillary
(GFAP),
GLAC
HOG
induced
by
MOG.
Unlike
rest
markers,
STAT-3
levels
elevated
MOG-treated
compared
untreated
ones.
expression
level
attenuated
both
PO3-MOG-treated
only
PO3-treated
lines.
On
contrary,
lines,
MBP,
GFAP,
significantly
expressed
at
higher
when
Conclusions:
findings
reported
this
article
are
be
used
foundation
further
vivo
research
order
pave
way
possible
use
probiotics
treatment
neuroinflammatory
diseases,
including
multiple
sclerosis.
Язык: Английский