The mediating role of primary sclerosing cholangitis in the association between ulcerative colitis and hepatobiliary cancer investigated through Mendelian randomization DOI Creative Commons
Fangming Wang, Junhui Xiao

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

This study explored the causal relationships among primary sclerosing cholangitis (PSC), ulcerative colitis (UC), and hepatobiliary cancer (HBC) by using bidirectional two-sample, two-step Mendelian randomization (MR) analysis. Genetic variants associated with PSC UC from FinnGen research database were used for instrumental variable-based analyses. Mediation analyses conducted to examine role of in HBC risk. The findings revealed a effect genetic predisposition on risk (inverse-variance-weighted [IVW] analysis odds ratio [OR] 1.145, p < 0.001), whereas no reverse causality was observed. Although showed direct risk, susceptibility significantly increased (IVW OR = 1.855, 0.001). further identified as significant mediator amplifying (effect size 0.083). These results established link between PSC, highlighted critical mediating impact

Язык: Английский

Dietary Supplementation with Rumen-Protected Arginine or N-Carbamylglutamate Enhances Fetal Liver Development in Nutrient-Restricted Pregnant Hu Ewes DOI Creative Commons

Yuexia Lin,

Lingwei Sun,

Mengqian He

и другие.

Animals, Год журнала: 2024, Номер 14(13), С. 1988 - 1988

Опубликована: Июль 5, 2024

This study was conducted in nutrient-restricted pregnant Hu ewes to determine whether rumen-protected arginine (RP-Arg) or N-carbamylglutamate (NCG) supplementation affects fetal liver growth and development. From 35 d 110 of gestation, 32 were randomly divided into four groups: a control group (100% the National Research Council (NRC) requirements), (50% NRC two treatment groups (ARG NCG, 50% requirements, supplemented with 20 g/day RP-Arg 5 respectively). Fetal body weights, performance, capability antioxidation, expression mRNA proteins apoptosis-related genes determined analyzed at gestation. The dry matter, water, fat, protein, ash components livers RG found be lower than CG group, these significantly higher NCG (

Язык: Английский

Процитировано

0
A Comparative Analysis of ADRs under Obeticholic Acid and Ursodeoxycholic Acid in Cholestatic Liver Diseases Using the FAERS Database DOI
Mengqing Zhu,

Linghui Tao,

Feiye Zhu

и другие.

Drug Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

The objective of this study was to compare the safety profiles OCA and UDCA for treatment PBC using FDA Adverse Event Reporting System database.

Язык: Английский

Процитировано

0
The mediating role of primary sclerosing cholangitis in the association between ulcerative colitis and hepatobiliary cancer investigated through Mendelian randomization DOI Creative Commons
Fangming Wang, Junhui Xiao

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

This study explored the causal relationships among primary sclerosing cholangitis (PSC), ulcerative colitis (UC), and hepatobiliary cancer (HBC) by using bidirectional two-sample, two-step Mendelian randomization (MR) analysis. Genetic variants associated with PSC UC from FinnGen research database were used for instrumental variable-based analyses. Mediation analyses conducted to examine role of in HBC risk. The findings revealed a effect genetic predisposition on risk (inverse-variance-weighted [IVW] analysis odds ratio [OR] 1.145, p < 0.001), whereas no reverse causality was observed. Although showed direct risk, susceptibility significantly increased (IVW OR = 1.855, 0.001). further identified as significant mediator amplifying (effect size 0.083). These results established link between PSC, highlighted critical mediating impact

Язык: Английский

Процитировано

0