Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review
Antibiotics,
Год журнала:
2025,
Номер
14(1), С. 68 - 68
Опубликована: Янв. 10, 2025
Essential
oils
(EOs)
are
gaining
ground
and
have
been
intensively
studied
due
to
their
widespread
use
in
the
pharmaceutical,
food,
cosmetics
industries.
The
essential
components
of
EOs
recognized
for
diverse
therapeutic
activities
gained
significant
attention
potential
antibacterial
activities.
Despite
popularity
potent
biological
properties,
bioactive
derivatives
still
not
comprehensively
characterized.
This
review
explores
efficacy
selected
EO
derivatives,
focusing
on
monoterpenes
chosen
(i.e.,
carvacrol,
menthol,
thymol)
phenylpropanoids
cinnamaldehyde
eugenol).
Furthermore,
this
highlights
recent
advancements
developing
these
components,
which
shown
improved
activity
with
reduced
toxicity.
By
summarizing
studies,
reveals
natural
compounds
as
promising
candidates
pharmaceuticals,
food
preservation,
alternatives
synthetic
antibiotics
combating
bacterial
resistance.
Язык: Английский
Novel systems biology experimental pipeline reveals matairesinol’s antimetastatic potential in prostate cancer: an integrated approach of network pharmacology, bioinformatics, and experimental validation
Briefings in Bioinformatics,
Год журнала:
2024,
Номер
25(5)
Опубликована: Июль 25, 2024
Matairesinol
(MAT),
a
plant
lignan
renowned
for
its
anticancer
properties
in
hormone-sensitive
cancers
like
breast
and
prostate
cancers,
presents
promising
yet
underexplored
avenue
the
treatment
of
metastatic
cancer
(mPC).
To
elucidate
specific
therapeutic
targets
mechanisms,
our
study
adopted
an
integrative
approach,
amalgamating
network
pharmacology
(NP),
bioinformatics,
GeneMANIA-based
functional
association
(GMFA),
experimental
validation.
By
mining
online
databases,
we
identified
27
common
mPC
MAT,
constructing
MAT-mPC
protein-protein
interaction
via
STRING
pinpointing
11
hub
such
as
EGFR,
AKT1,
ERBB2,
MET,
IGF1,
CASP3,
HSP90AA1,
HIF1A,
MMP2,
HGF,
MMP9
with
CytoHuba.
Utilizing
DAVID,
Gene
Ontology
(GO)
analysis
highlighted
metastasis-related
processes
epithelial-mesenchymal
transition,
positive
regulation
cell
migration,
key
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathways,
including
cancer,
PI3K-Akt,
MAPK
signaling,
while
web
resources
UALCAN
GEPIA2
affirmed
clinical
significance
top
patient
survival
gene
expression
patterns.
Our
innovative
GMFA
enrichment
method
further
enriched
findings.
Molecular
docking
analyses
demonstrated
substantial
interactions
between
MAT
targets.
Simulation
studies
confirmed
stable
selected
Experimental
validation
PC3
cells,
employing
quantitative
real-time
reverse-transcription
PCR
various
cell-based
assays,
corroborated
MAT's
antimetastatic
effects
on
mPC.
Thus,
this
exhaustive
NP
analysis,
complemented
by
GMFA,
molecular
docking,
dynamics
simulations,
validations,
underscores
multifaceted
role
targeting
through
diverse
avenues.
Nevertheless,
comprehensive
vitro
is
imperative
to
solidify
these
Язык: Английский
Influence of extraction solvents on total phenolic content and antioxidant activity of Tunisian Thymbra capitata (L.) Cav. aerial parts extracts
Ines Taieb,
Amel Azaza,
Farah Zidi
и другие.
Journal of Phytomolecules and Pharmacology,
Год журнала:
2025,
Номер
4(1), С. 07 - 12
Опубликована: Апрель 23, 2025
Язык: Английский
Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 365 - 365
Опубликована: Фев. 4, 2024
Ageing
is
a
natural
process
characterized
by
time-dependent
decline
of
physiological
integrity
that
compromises
functionality
and
inevitably
leads
to
death.
This
also
quite
relevant
in
major
human
pathologies,
being
primary
risk
factor
neurodegenerative
diseases,
metabolic
disorders,
cardiovascular
diseases
musculoskeletal
disorders.
Bearing
this
mind,
it
not
surprising
research
aiming
at
improving
health
during
has
burst
the
last
decades.
Importantly,
hallmarks
ageing
phenotype
have
been
identified,
knowledge
for
future
studies
towards
identification
putative
pharmaceutical
targets,
enabling
development
preventive/therapeutic
strategies
improve
longevity.
In
context,
aromatic
plants
emerged
as
source
potential
bioactive
volatile
molecules,
mainly
monoterpenes,
with
many
referring
their
anti-ageing
potential.
Nevertheless,
an
integrated
review
on
current
lacking,
several
approaches
studying
isolated
or
overall
effect,
without
depicting
possible
mechanisms
action.
Herein,
we
aim
provide
updated
systematization
monoterpenes
recently
proposed
hallmarks,
highlight
main
action
already
well
chemical
entity–activity
relations.
By
gathering
categorizing
available
scattered
information,
identify
important
gaps
could
help
pave
way
field.
Язык: Английский
Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging
Plants,
Год журнала:
2023,
Номер
12(21), С. 3741 - 3741
Опубликована: Окт. 31, 2023
With
the
increase
in
global
life
expectancy,
maintaining
health
into
old
age
becomes
a
challenge,
and
research
has
thus
concentrated
on
various
strategies
which
aimed
to
mitigate
effects
of
skin
aging.
Aromatic
plants
stand
out
as
promising
sources
anti-aging
compounds
due
their
secondary
metabolites,
particularly
essential
oils
(EOs).
The
aim
this
study
was
ascribe
Ferulago
lutea
EO
several
biological
activities
that
could
be
useful
context
obtained
using
hydrodistillation
characterized
by
gas
chromatography–mass
spectrometry
(GC/MS).
anti-inflammatory
potential
assessed
lipopolysaccharide
(LPS)-stimulated
macrophages.
effect
cell
migration
disclosed
scratch
wound
assay.
Lipogenesis
induced
T0901317,
hyperpigmentation
with
3-isobutyl-1-methylxantine
(IBMX)
senescence
etoposide.
Our
results
show
mainly
α-pinene
limonene.
able
decrease
nitric
oxide
(NO)
release
well
iNOS
pro-IL-1β
protein
levels.
promoted
healing
while
decreasing
lipogenesis
having
depigmenting
effects.
also
reduced
senescence-associated
β-galactosidase,
p21/p53
levels
nuclear
accumulation
γH2AX.
Overall,
our
highlights
properties
F.
make
it
compelling
candidate
for
dermocosmetics
applications.
Язык: Английский
Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging
Опубликована: Окт. 23, 2023
As
global
life
expectancy
continues
to
rise,
we
are
challenged
with
maintaining
health
into
old
age,
and
research
has
thus
concentrated
on
various
strategies
aimed
at
mitigating
the
effects
of
skin
aging.
Aromatic
plants
stand
out
as
potential
sources
anti-aging
compounds
due
their
secondary
metabolites,
particularly
essential
oils
(EO).
The
aim
this
study
was
ascribe
Ferulago
lutea
EO
several
biological
activities
that
could
be
useful
in
context
obtained
using
hydrodistillation
characterized
by
gas
chromatography-mass
spectrometry
(GC/MS).
anti-inflammatory
assessed
lipopolysaccharide
(LPS)-stimulated
macrophages.
effect
cell
migration
disclosed
scratch
wound
assay.
Lipogenesis
induced
T0901317,
hyperpigmentation
3-isobutyl-1-methylxantine
(IBMX)
senescence
Etoposide.
Our
results
show
mainly
α-pinene
limonene.
able
decrease
nitric
oxide
(NO)
release
well
iNOS
pro-IL-1β
protein
levels.
promoted
healing
while
decreasing
lipogenesis
having
depigmenting
effects.
also
reduced
associated
β-galactosidase
p21/p53
levels
nuclear
accumulation
γH2AX.
Overall,
our
highlights
properties
F.
make
it
a
compelling
candidate
for
dermocosmetics
applications.
Язык: Английский
Unlocking the Bioactive Potential and Exploring Novel Applications for Portuguese Endemic Santolina impressa
Plants,
Год журнала:
2024,
Номер
13(14), С. 1943 - 1943
Опубликована: Июль 15, 2024
The
infusion
of
Язык: Английский
Exploring the Traditional Uses of Thymbra capitata Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging
Pharmaceuticals,
Год журнала:
2023,
Номер
16(9), С. 1202 - 1202
Опубликована: Авг. 23, 2023
Inflammation
plays
a
pivotal
role
in
the
resolution
of
infection
or
tissue
damage.
In
addition,
inflammation
is
considered
hallmark
aging,
which
turn
compromises
wound
healing.
Thymbra
capitata
an
aromatic
plant,
whose
infusion
traditionally
used
as
anti-inflammatory
and
wound-healing
agent.
this
study,
T.
was
prepared
characterized
by
HPLC-PDA-ESI-MSn
its
safety
profile
determined
resazurin
metabolic
assay.
The
potential
revealed
lipopolysaccharide
(LPS)-stimulated
macrophages
assessing
nitric
oxide
(NO)
release
levels
inducible
synthase
(iNOS)
interleukin-1β
pro-form
(pro-IL-1β).
Wound-healing
capacity
using
scratch
activity
senescence-associated
β-galactosidase
to
unveil
anti-senescent
potential,
along
with
nuclear
accumulation
yH2AX
p21
levels.
antiradical
assessed
DPPH
ABTS
scavenging
assays.
contains
predominantly
rosmarinic
acid
salvianolic
acids.
extract
decreased
NO,
iNOS,
pro-IL-1β
Interestingly,
promoted
healing
activity,
well
present
work
highlights
strong
antiradical,
anti-inflammatory,
capacities,
corroborating
traditional
uses
ascribed
plant.
We
have
described,
for
first
time
extract,
properties.
Язык: Английский