Mancozeb
(MZ),
an
EBDC
fungicide,
has
been
found
to
contaminate
agricultural
products
and
cause
male
reproductive
toxicity.
The
phytochemical
compounds
of
white
N.
nucifera
petal
extract
(WNPE)
its
effects
on
metabolomic
profiles
function
in
rats
poisoned
with
MZ
were
investigated.
Seventy-two
mature
Wistar
divided
into
nine
groups
(n
=
8)
and,
for
30
days,
gavaged
WNPE
at
doses
0.55,
1.10,
2.20
mg/kg;
given
distilled
water;
or
co-gavaged
WNPE.
By
evaluating
the
1H-NMR
WNPE,
myricetin,
apigenin,
luteolin,
ferulic
acid,
caffeic
ascorbic
genistein,
chlorogenic
naringenin,
ellagic
acid
found,
essential
minerals
evaluated
by
AAS.
NMR
spectra
demonstrated
that
creatine,
carnitine,
ACh,
choline
significantly
higher
than
MZ.
gavaging
before
poisoning
them
improved
acetylcholine,
progressive
sperm
motility,
viability,
normal
morphology
compared
who
only
received
It
was
concluded
had
a
toxicity
effect
system
via
decreased
profiles,
affecting
morphology.
Nevertheless,
plenty
bioactive
could
enhance
which
are
related
quality
rats.
should
be
considered
as
alternative
dietary
supplement
can
protect
against
rat
system.
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100030 - 100030
Опубликована: Янв. 6, 2024
Delayed
wound
healing
brings
additional
physical,
mental,
and
financial
burdens.
Microneedles
(MNs)
are
a
novel
dressing
form
can
incorporate
drug
delivery
systems.
Quercetin
is
known
for
its
remarkable
antioxidant
capacity
may
have
distinctive
effect
on
healing.
We
designed
constructed
gelatin
methacryloyl
(GelMa)
MNs
carrying
(Q-MNs).
In
vitro,
the
physical
properties,
cell
safety,
migration,
angiogenesis,
collagen
formation,
oxidative
stress
levels,
were
performed
to
characterize
Q-MNs.
vivo,
full-thickness
skin
models
established
evaluate
re-epithelialization
impact
of
control,
MN,
Q-MN
groups.
The
Q-MNs
mechanically
strong
enough
penetrate
sustained
possessed
good
biocompatibility.
Moreover,
evidently
facilitated
both
in
vitro
promoted
formation
neo-angiogenesis,
reduction
levels.
could
motivate
with
enhanced
vascularization
decreased
thus
providing
feasible
strategy
Molecules,
Год журнала:
2024,
Номер
29(13), С. 3206 - 3206
Опубликована: Июль 5, 2024
Quercetin,
a
bioactive
plant
flavonoid,
is
an
antioxidant,
and
as
such
it
exhibits
numerous
beneficial
properties
including
anti-inflammatory,
antiallergic,
antibacterial
antiviral
activity.
It
occurs
naturally
in
fruit
vegetables
apples,
blueberries,
cranberries,
lettuce,
present
waste
onion
peel
or
grape
pomace
which
constitute
good
sources
of
quercetin
for
technological
pharmaceutical
purposes.
The
presented
study
focuses
on
the
role
prevention
treatment
dermatological
diseases
analyzing
its
effect
at
molecular
level,
signal
transduction
metabolism.
Presented
aspects
potential
skin
include
protection
against
aging
UV
radiation,
stimulation
wound
healing,
reduction
melanogenesis,
oxidation.
article
discusses
(plant
products
included),
methods
medical
administration,
perspectives
further
use
dermatology
diet
therapy.
