Nutrients,
Год журнала:
2025,
Номер
17(9), С. 1568 - 1568
Опубликована: Май 2, 2025
Due
to
the
extensive
types
of
etiologies
and
risks
causing
over
600
mental
health
issues,
convene
adequate
recommendations
in
primary
care
is
a
difficult
assignment.
The
starting
point
for
preventive
interventions
on
neurologic
disorders
involves
scrutinizing
risk
factors
while
targeting
multiple
hazards
order
increase
success
an
early
precautionary
mediation
plan
action.
factor
most
neurodegenerative
diseases
increasing
worldwide
median
age,
although
one
seven
youngsters
also
experience
disability,
namely
depression,
representing
decline
well-being
conferring
considerable
global
public
challenge.
brain
operates
optimally
when
supported
by
holistic
approach
engaging
several
aspects,
diet
becoming
integral
part
strategies.
Treatment
presently
dominated
pharmacotherapy,
but
additional
strategies
are
needed
prevent
treat
disorders.
Dietary
modification
can
prove
be
cost-effective
strategy
prevention
and,
certain
conditions,
treatment
neurological
Molecules
dietary
ingredients,
micronutrients,
phytonutrients,
additives
may
modulate
depression
associated
biomarkers.
Nutritional
exposure
during
developmental
stages
maternal
impact,
lifestyles,
modulation
gut
microbiota
through
as
novel
therapies
various
neuropsychiatric
conditions
gaining
interest
maintaining
health.
Bioactive
substances
present
different
mushroom
species
have
been
ascribed
both
direct
indirect
mechanisms
influence
neurobehavior,
here
we
support
recognition
nutrition
influential
element
management
some
concerns.
Scientific
evidence
demonstrating
unequivocal
link
between
nutritional
mushrooms
cognitive
only
beginning
emerge,
medicine
should
considered
care.
Redox Biology,
Год журнала:
2025,
Номер
80, С. 103491 - 103491
Опубликована: Янв. 8, 2025
Adolescent
depression
is
a
globally
concerned
mental
health
issue,
the
pathophysiological
mechanisms
of
which
remain
elusive.
Membrane
lipids
play
crucial
role
in
brain
development
and
function,
potentially
serving
as
crossroad
for
abnormalities
neurotransmitters,
neuroendocrine,
inflammation,
oxidative
stress,
energy
metabolism
observed
depressed
adolescents.
The
primary
aim
this
study
was
to
investigate
erythrocyte
membrane
lipid
profile
adolescent
depression.
A
total
2838
were
detected
quantified
81
adolescents
with
67
matched
healthy
using
ultra-high
performance
liquid
chromatography-mass
spectrometry.
Depressed
exhibited
significantly
different
characteristics
compared
controls.
Specifically,
levels
cholesterol,
sphingomyelins,
ceramides
increased,
while
ether
decreased
patients.
Moreover,
patients
showed
reduced
polyunsaturated
fatty
acids
elevated
lipophilic
index
membrane,
suggesting
diminished
fluidity.
higher
oxidized
plasma
malondialdehyde
depression,
indicating
presence
stress.
Importantly,
damage
associated
more
severe
depressive
symptoms
worse
cognitive
function
In
addition,
fluidity
may
be
partly
responsible
blunted
niacin
skin
flushing
response
found
conclusion,
our
results
reveal
impaired
homeostasis
implicate
dysfunction
brain.
These
findings
offer
new
insights
into
underlying
molecular
highlighting
potential
counteracting
promising
avenue
future
therapeutic
interventions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15071 - 15071
Опубликована: Окт. 11, 2023
The
multifactorial
etiology
of
major
depressive
disorder
(MDD)
includes
biological,
environmental,
genetic,
and
psychological
aspects.
Recently,
there
has
been
an
increasing
interest
in
metallomic
studies
psychiatry,
aiming
to
evaluate
the
role
chosen
trace
elements
MDD
as
well
progression
symptoms.
This
narrative
review
aims
summarize
available
literature
on
relationship
between
concentration
serum
patients
with
onset
this
psychiatric
condition.
authors
reviewed
PubMed,
Web
Science,
Scopus
databases
searching
for
that
had
investigated
so
far
further
evaluated
them
paper.
Ultimately,
15
were
evaluated,
namely,
zinc,
magnesium,
selenium,
iron,
copper,
aluminium,
cadmium,
lead,
mercury,
arsenic,
calcium,
manganese,
chromium,
nickel,
phosphorus.
association
psychiatry
developing
dynamically
recently.
According
results
current
research,
metallomics
might
act
a
potential
screening
tool
while
at
same
time
providing
assessment
severity
Either
deficiencies
or
excessive
amounts
be
associated
symptoms
even
disease
among
people
predisposed
MDD.
International Journal of Mental Health Nursing,
Год журнала:
2024,
Номер
33(5), С. 1197 - 1211
Опубликована: Апрель 15, 2024
Abstract
Mental
health
problems
in
nurses
are
prevalent
and
impairing.
To
date,
no
literature
has
comprehensively
synthesised
cohort
evidence
on
mental
among
nurses.
This
scoping
review
aimed
to
synthesise
the
existing
risk
factors
consequences
of
A
systematic
search
was
conducted
PubMed,
EMBASE,
Epistemonikos
database,
Web
Science,
CINAHL,
PsycINFO
from
inception
March
2023.
We
identified
171
studies
16
countries,
mostly
(95.3%)
high‐income
economies.
indicated
that
worldwide
encountered
significant
challenges,
including
depression,
cognitive
impairment,
anxiety,
trauma/post‐traumatic
stress
disorder,
burnout,
sleep
other
negative
problems.
These
were
closely
related
various
modifiable
such
as
nurses'
behaviours
lifestyles,
social
support,
workplace
bullying
violence,
shift
work,
job
demands,
resources.
Moreover,
have
effects
their
physical
health,
behaviour
lifestyle,
occupation
organisation,
intrapersonal
factors.
findings
provided
an
enhanced
understanding
complexities
nurses,
shed
light
policy
enactment
alleviate
impact
Addressing
should
be
a
top
priority.
Neuropsychopharmacology Reports,
Год журнала:
2025,
Номер
45(1)
Опубликована: Янв. 4, 2025
ABSTRACT
Introduction
Substance
use
disorders,
particularly
alcohol
represent
a
significant
public
health
problem,
with
adolescents
vulnerable
to
their
adverse
effects.
This
study
examined
the
possible
anxiolytic
and
antidepressant
effects
of
biotin,
crucial
vitamin
for
brain
function,
in
attenuating
behavioral
neurobiological
changes
associated
withdrawal
adolescent
rats.
Materials
Methods
Sixty
male
Sprague–Dawley
rats
were
exposed
20%
ethanol
solution
21
days,
followed
by
21‐day
drug‐free
period
assess
long‐term
physiological
changes.
Behavioral
assessments
included
Open
Field
Test,
Elevated
Plus
Maze,
Forced
Swimming
administered
post‐withdrawal
evaluate
anxiety
depression
behaviors.
Additionally,
biochemical
analyses
performed
measure
serotonin
levels,
monoamine
oxidase‐A
(MAO‐A)
activity,
BDNF
concentrations.
Results
The
results
indicate
that
significantly
induced
anxiety‐
depression‐like
behavior
However,
treatment
at
higher
doses,
effectively
attenuated
these
withdrawal‐related
Mechanistically,
biotin
administration
was
found
regulate
oxidase
brain‐derived
neurotrophic
factor,
glial
fibrillary
acidic
protein,
alleviate
oxidative
stress
markers
cortical
tissue.
Discussion
this
suggest
may
have
therapeutic
potential
alleviating
negative
withdrawal,
those
related
depression.
Further
research
is
needed
elucidate
underlying
mechanisms
examine
clinical
supplementation
individuals
undergoing
withdrawal.
European journal of psychotraumatology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 13, 2025
Background:
Depression
is
a
prevalent
mental
disorder
with
high
morbidity
and
mortality
globally.
Methylmalonic
acid
(MMA)
involved
in
the
pathogenesis
of
numerous
diseases.
However,
it
unclear
whether
there
an
association
between
MMA
prevalence
depression.
Introduction
Obsessive-compulsive
disorder
(OCD)
is
a
persistent
psychiatric
condition
that
causes
significant
clinical
and
functional
impairments.
Recent
research
suggests
link
between
deficiencies
in
micronutrients,
particularly
vitamin
B12,
folic
acid,
elevated
homocysteine,
the
development
of
OCD.
This
study
investigates
blood
levels
these
micronutrients
their
relationship
to
OCD
severity,
with
an
emphasis
on
potential
gender
differences.
Methods
cross-sectional
included
300
drug-free
patients.
Serum
homocysteine
were
measured
using
established
biochemical
methods.
The
Yale-Brown
Obsessive
Compulsive
Scale
(Y-BOCS)
was
used
assess
severity.
Data
examined
determine
relationships
micronutrient
severity
differences
male
female
Results
found
women
had
higher
B12
(405.3
±
15.1
vs.
360.4
14.3)
acid
(7.18
0.27
5.76
0.25)
but
lower
(9.35
0.64
14.4
0.60)
compared
men.
Higher
linked
participants
having
education
(at
college
or
university,
where
subjects
are
studied
at
advanced
level)
those
primary-level
education.
Lower
family
mental
health
history
noncommunicable
diseases.
Women
exhibited
substance
use
rates
self-harm
suicide
attempts.
Elevated
longer
illness
duration
more
severe
symptoms.
Conclusion
These
findings
suggest
imbalances
may
contribute
treatment
resistance.
Gender-specific
variations
could
provide
valuable
insights
into
personalized
therapy
choices.
Further
longitudinal
studies
needed
understand
as
therapeutic
targets.
Nutrients,
Год журнала:
2024,
Номер
16(12), С. 1955 - 1955
Опубликована: Июнь 19, 2024
Ultra-processed
foods
(UPFs)
like
pastries,
packaged
snacks,
fast
foods,
and
sweetened
beverages
have
become
dominant
in
the
modern
food
supply
are
strongly
associated
with
numerous
public
health
concerns.
While
physical
consequences
of
UPF
intake
been
well
documented
(e.g.,
increased
risks
cardiometabolic
conditions),
less
empirical
discussion
has
emphasized
mental
chronic
consumption.
Notably,
unique
characteristics
UPFs
artificially
high
levels
reinforcing
ingredients)
influence
biological
processes
dopamine
signaling)
a
manner
that
may
contribute
to
poorer
psychological
functioning
for
some
individuals.
Importantly,
gold-standard
behavioral
lifestyle
interventions
treatments
specifically
disordered
eating
do
not
acknowledge
direct
role
play
sensitizing
reward-related
neural
functioning,
disrupting
metabolic
responses,
motivating
subsequent
cravings
intake.
The
lack
consideration
influences
on
is
particularly
problematic
given
growing
scientific
support
addictive
properties
these
utility
ultra-processed
addiction
(UPFA)
as
novel
clinical
phenotype
endorsed
by
14–20%
individuals
across
international
samples.
overarching
aim
present
review
summarize
science
how
affect
health,
emphasizing
contributing
mechanisms.
Specifically,
authors
will
(1)
describe
corporate-sponsored
research
financial
agendas
contributed
contention
debate
about
health;
(2)
define
their
nutritional
characteristics;
(3)
observed
associations
between
conditions,
especially
depression;
(4)
outline
evidence
UPFA;
(5)
nuanced
treatment
considerations
comorbid
UPFA
disorders.
Substance Use & Addiction Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Background:
Substance
use
disorders
(SUDs)
represent
a
significant
global
public
health
challenge,
with
affected
individuals
often
exhibiting
poor
dietary
habits,
nutritional
deficiencies,
and
compromised
mental
physical
health.
This
scoping
review
evaluates
existing
literature
on
intake
in
SUDs,
focusing
the
potential
benefits
of
plant-based
interventions
for
improving
status
supporting
recovery.
Methods:
A
was
conducted
following
PRISMA
guidelines.
Four
databases
were
searched
using
PICO-based
terms,
targeting
studies
assessing
patients
SUD,
particularly
interventions.
Inclusion
criteria
reporting
macro-
micronutrient
among
while
lacking
direct
data
excluded.
Study
quality
appraised
STROBE
checklist.
Results:
The
search
yielded
1142
articles,
6
meeting
inclusion
(4
from
United
States
2
Iran).
Patients
SUD
exhibited
deficiencies
iron
(−16.8%,
P
=
.04),
folate
(−15.0%,
vitamins
E
A,
alongside
diets
high
simple
carbohydrates
unhealthy
processed
foods.
Plant-based
associated
improved
Healthy
Eating
Index
scores
(
<
.001),
increased
resilience
(+31%,
.031),
enhanced
self-esteem
.043).
High
energy
low
multivitamin
reported
methadone-treated
patients,
emphasizing
need
to
address
nutrient
gaps
support
Conclusion:
may
offer
promising
strategy
improve
outcomes
SUD.
However,
are
limited,
small
sample
sizes
variability
assessments.
Future
research,
including
randomized
controlled
trials,
is
needed
establish
efficacy
feasibility
integrating
nutrition
into
treatment
programs.
Addressing
barriers
such
as
socioeconomic
challenges
food
access
also
crucial
implementing
effective
