Zingiberaceae wonders: the antioxidant powerhouse for optimal health

Animal Science Papers and Reports, Год журнала: 2025, Номер 43(1), С. 1 - 18

Опубликована: Март 1, 2025

Abstract A discrepancy between the production of reactive oxygen species [ROS] and body’s capacity to cleanse or repair resulting damage is known as oxidative stress. Antioxidants shield cells against ROS free radicals, which are extremely because their unpaired electrons, by preventing other molecules from oxidizing. Zingiberaceae family, well-known for its culinary therapeutic applications, scavenge chelate metal ions, alter enzyme function, control gene expression. The antioxidant plant extracts compounds assessed using in vitro tests such DPPH, FRAP, ABTS. Animal research conducted vivo clarifies these plants’ bioavailability, metabolism, impacts on diseases linked Lipid peroxidation, protein oxidation, DNA damage, endogenous defenses examples biomarkers stress that shed light mechanisms behind treatments highlight potential a treatment

Язык: Английский

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The potential of food-derived peptides in alleviating depressed mood: Function, evaluation and mechanism

Food Research International, Год журнала: 2025, Номер unknown, С. 116520 - 116520

Опубликована: Апрель 1, 2025

Язык: Английский

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Neuroprotective potential of paddy rice: advancing nutritional and therapeutic strategies for brain health

Nutritional Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Апрель 28, 2025

This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, phenolic acids. We conducted comprehensive existing studies detailing mechanisms by which bioactives support brain health. These were examined for their effects oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, neurogenesis promotion. Bioactives such as gamma-oryzanol ferulic acid found to decrease neuroinflammatory markers function. Research shows enhance neural resilience cognitive function, suggesting role managing disorders like Parkinson's Alzheimer's disease. While preclinical evidence underscores therapeutic promise bioactives, further clinical are needed confirm efficacy, establish optimal dosages, improve bioavailability. advocates advanced nutraceutical development using bridge findings applications.

Язык: Английский

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In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways

Biomedical Reports, Год журнала: 2024, Номер 20(6)

Опубликована: Апрель 4, 2024

Stroke is an important medical problem in developing countries, characterized by a sudden disruption of blood supply to the brain, either through occlusion or hemorrhage. It major cause neurological impairment, resulting high costs. The present study examined effect 6‑gingerol on morphological changes, antioxidant defenses, and anti‑apoptotic factors p38 mitogen‑activated protein kinase (MAPK) mitofusin (Mfn)2, rat model focal cerebral ischemia. A total 60 healthy male Wistar rats were randomly allocated into six groups: Control, right middle artery (Rt.MCAO) + vehicle, Rt.MCAO piracetam, 6‑Gin 5, 10 20 mg/kg BW groups. results indicated that treatment for duration 7 days reverses alterations, enhances catalase glutathione peroxidase activities, reduces Bax, caspase‑3 MAPK expression, increases Bcl‑xL Mfn2 expression cortex hippocampus. In conclusion, demonstrated significant in vivo effectiveness mitigating pathological changes induced This beneficial attributed, at least part, preservation defenses activation pathways.

Язык: Английский

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A review on the ethnopharmacological importance and biochemical composition of medicinal plants within the Zingiberaceae family

Plant Science Today, Год журнала: 2024, Номер unknown

Опубликована: Авг. 3, 2024

The Zingiberaceae family, known for its diverse range of plant species, plays a crucial role in traditional medicine, culinary arts, and aesthetics across both developing developed countries. However, the limited documentation medicinal uses presents significant challenge. This review summarises therapeutic physicochemical makeup ten species. study emphasizes presence bioactive chemicals, such as flavonoids phenolics, these plants. These compounds offer antioxidant, anti-inflammatory, antibacterial advantages. Extensive literature searches were conducted using major academic databases to ensure inclusion most relevant up-to-date studies field. primarily concentrates on extensively utilized rhizomes, while also examining less-explored components plants, including leaves, stems, flowers, seeds, fruits, which may possess value. Emphasis is placed antioxidant properties leaves with notable gap research regarding flowers seeds. By their radical scavenging abilities, underscores significance species medicine promising applications modern healthcare animal feeds. exploration not only documents plants but identifies gaps current research, advocating further investigation into under-researched parts family. findings suggest that expanding seeds could reveal new potentials promoting human health.

Язык: Английский

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Recent trends and therapeutic potential of phytoceutical‐based nanoparticle delivery systems in mitigating non‐small cell lung cancer

Molecular Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Lung cancer is the leading cause of death globally, with non‐small cell lung accounting for majority (85%) cases. Standard treatments including chemotherapy and radiotherapy present multiple adverse effects. Medicinal plants, used centuries, are traditionally processed by methods such as boiling oral ingestion, However, water solubility, absorption, hepatic metabolism reduce phytoceutical bioavailability. More recently, isolated molecular compounds from these plants can be extracted phytoceuticals administered either individually or an adjunct standard therapy. Phytoceuticals have been shown to alleviate symptoms, may dosage and, in some cases, enhance pharmaceutical mechanisms. Research has identified many phytoceuticals' actions on cancer‐associated pathways, oncogenesis, tumour microenvironment, proliferation, metastasis, apoptosis. The development novel nanoparticle delivery systems solid lipid nanoparticles, liquid crystalline liposomes enhanced bioavailability targeted pharmaceuticals phytoceuticals. This review explores biological pathways associated cancer, a diverse range phytoceuticals, they act upon, pros cons several systems.

Язык: Английский

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Evaluation of the Acute Toxicity of the Ethanolic Extract of the Rhizome of Zingiber officinale Roscoe in Rats

Pharmacognosy Journal, Год журнала: 2024, Номер 16(2), С. 323 - 331

Опубликована: Май 10, 2024

Background: Ginger has pharmacological activities such as anticancer, antidiabetic, antioxidant, antimicrobial, anti-neuroinflammatory, and chemotherapy-induced nausea vomiting. Objective: The research aims to evaluate the acute toxicity of ethanolic extract rhizome Zingiber officinale Roscoe in rats. Materials Methods: was administrated at doses 300 2000 mg/ Kg/day female male Changes body weight were determined during 14-day treatment period, on last day treatment, blood drawn, euthanasia performed, removing organs for histological analysis. Biochemical parameters measured. Results: specimens not show statistically significant variation. In liver, mild lymphocytic portal inflammation moderate hepatic steatosis occurred mg/kg/day. kidneys exhibited a infiltration around renal tubules glomeruli same dose. brain showed slight increase count astrocytes with focal glial reaction highest stomach heart also inflammatory processes dose biochemical parameters, differences observed between mg/Kg/day control group. Conclusion: Z. rats revealed histopathological changes kidneys, brain, stomach, heart, besides mg/Kg/day.

Язык: Английский

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The Discovery of Benzylidene‐Indenone as Selective Butyrylcholinesterase Inhibitor with Choline Acetyltransferase Gene and Neurite Promoting Abilities

ChemistrySelect, Год журнала: 2024, Номер 9(19)

Опубликована: Май 15, 2024

Abstract Alzheimer's disease (AD) is a multifactorial and progressive neurodegenerative disease, associated with aging. A total of forty benzylidene‐indenone derivatives were synthesized in search multi‐target‐directed ligands (MTDL) against AD. Compound 9 was found as the most promising MTDL this study. It demonstrated to selectively inhibit human butyrylcholinesterase, increase gene expression choline acetyltransferase (CHAT), promote neurite outgrowth SH‐SY5Y cells. The compound also predicted be able permeate across lipid‐infused bilayer, indicating its ability cross blood‐brain barrier. abovementioned findings show analogs warrant further exploration potential anti‐AD agents.

Язык: Английский

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Análise prospectiva do potencial antiepiléptico de espécies das famílias Passifloraceae, Zingiberaceae e Cannabaceae

Research Society and Development, Год журнала: 2024, Номер 13(7), С. e6513745760 - e6513745760

Опубликована: Июль 14, 2024

A epilepsia é uma condição neurológica crônica caracterizada por convulsões recorrentes e sem cura definitiva, afetando significativamente a qualidade de vida dos pacientes. O tratamento convencional envolve o uso drogas antiepilépticas, que, embora sejam eficazes no controle das crises, podem causar série efeitos colaterais prejudiciais não abordam causa subjacente da doença. Além disso, pacientes com resistente medicamentos enfrentam desafios adicionais, incluindo comprometimento cognitivo baixo desempenho educacional ocupacional. Nesse contexto, pesquisa novas alternativas para se torna crucial. Uma área promissora estudo extratos naturais plantas medicinais, que têm sido investigados seu potencial antiepilético. Este concentra nas famílias Passifloraceae, Zingiberaceae Cannabaceae devido à sua riqueza em compostos bioativos propriedades farmacológicas. científica revelou várias espécies dessas possuem atividades antiepilépticas anticonvulsivantes, fornecendo base desenvolvimento novos tratamentos. No entanto, os enfrentados na obtenção patentes produtos fitoterápicos Brasil destacam necessidade investimentos adicionais políticas regulatórias claras nessa área. Portanto, contínua sobre terapêutico juntamente esforços melhorar acesso tratamentos inovadores, essencial manejo

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Unveiling the Neuroprotective Potential of Date Palm (Phoenix dactylifera): A Systematic Review

Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1221 - 1221

Опубликована: Сен. 17, 2024

Background: Neurodegenerative diseases primarily afflict the elderly and are characterized by a progressive loss of neurons. Oxidative stress is intricately linked to advancement these conditions. This study focuses on Phoenix dactylifera (P. dactylifera; Family: Arecaceae), commonly known as “Ajwa,” globally cultivated herbal plant renowned for its potent antioxidant properties reported neuroprotective effects in pharmacological studies. Method: comprehensive systematic review delves into extracts their phytochemical components, with particular emphasis P. potential benefits. Preferred reporting items systemic reviews meta-analysis (PRISMA) were employed articles. Results: The includes 269 articles published literature 17 selected after qualitative analysis. growing body research underscores critical role polyphenolic compounds found dactylifera, which significantly contribute through mechanisms. Despite emerging insights actions further investigation essential fully elucidate specific pathways it confers neuroprotection. Conclusions: Like many other plant-based supplements, dactylifera’s likely mediated synergistic interactions among diverse bioactive compounds, rather than any single constituent alone. Therefore, additional preclinical clinical studies necessary explore therapeutic comprehensively, especially terms targeted activities aimed at mitigating neurodegenerative processes. Such holds promise advancing our understanding potentially harnessing benefits

Язык: Английский

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