Effects of Weight Loss on Key Obesity-Related Biomarkers Linked to the Risk of Endometrial Cancer: A Systematic Review and Meta-Analysis
Cancers,
Год журнала:
2024,
Номер
16(12), С. 2197 - 2197
Опубликована: Июнь 11, 2024
Endometrial
cancer
(EC)
includes
various
histologic
types,
with
estrogen-dependent
endometrioid
carcinoma
being
the
most
common.
Obesity
significantly
increases
risk
of
developing
this
type,
especially
in
postmenopausal
women,
due
to
elevated
estrogen
production
by
adipocytes.
This
review
examines
impact
weight
loss
from
different
interventions
on
reducing
obesity-related
factors
for
EC.
A
systematic
and
meta-analysis
were
conducted
three
interventions:
bariatric
surgery,
pharmacotherapy,
lifestyle
changes.
The
effects
these
inflammatory
biomarkers
(CRP,
TNF-α,
IL-6)
hormones
(leptin,
estrogen)
analyzed.
Data
controlled
studies
pooled
assess
significance
biomarkers.
Despite
heterogeneity,
surgery
resulted
an
overall
25.8%
reduction,
outperforming
pharmacotherapy
interventions.
Weight
reduced
CRP
levels
33.5%
IL-6
41.9%.
TNF-α
decreased
13%
percent
over
7%.
Leptin
also
significantly,
although
exact
percentage
was
not
statistically
significant.
effectively
reduces
proinflammatory
markers
associated
increased
strengths
include
a
comprehensive
examination
weight-loss
large
pool
participants.
However,
limitations
high
heterogeneity
among
only
43%
participants
postmenopausal.
Limited
data
sex
racial
disparities
underscore
need
further
research.
Язык: Английский
Mechanism of Action and Risk Prediction of Adiponectin in Cardiovascular Diseases
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(8)
Опубликована: Авг. 19, 2024
Being
one
of
the
pivotal
adipocytokines,
adiponectin
binds
to
various
receptors
and
exerts
diverse
biological
functions,
encompassing
anti-fibrosis,
anti-atherosclerosis,
anti-ischemia-reperfusion,
regulation
inflammation,
modulation
glucose
lipid
metabolism.
Alterations
in
levels
are
observed
patients
afflicted
with
cardiovascular
diseases.
This
paper
comprehensively
reviews
impact
on
pathogenesis
progression
diseases,
elucidating
underlying
cellular
molecular
mechanisms
along
associated
cell
signaling
pathways.
Furthermore,
it
deliberates
diagnostic
predictive
efficacy
as
a
protein
marker
for
Additionally,
outlines
methods
manipulating
vivo.
A
thorough
understanding
these
interconnections
can
potentially
inform
clinical
strategies
prevention
management
Язык: Английский
Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
10
Опубликована: Янв. 10, 2024
In
large-scale
intensive
farms,
dairy
goats
often
undergo
frequent
estrus
synchronization
(ES)
treatment,
which
may
result
in
a
decline
reproductive
performance;
however,
the
underlying
mechanism
remains
unclear.
The
present
study
aimed
to
investigate
effect
of
pregnant
mare
serum
gonadotropin
(PMSG)
and
progesterone
(P4)-mediated
ES
treatment
on
fertility
goats,
while
also
identifying
key
metabolic
endocrine
mechanisms
that
influence
performance
does
subjected
repeated
treatment.
Forty-eight
Saanen
were
randomly
assigned
two
groups
(24
each)
received
treatments
either
thrice
fortnightly
(3-PMSG)
or
once
(1-PMSG)
simultaneously
with
third
3-PMSG
group
during
breeding
season.
was
performed
via
intravaginal
insertion
controlled
internal
drug
release
(CIDR)
device
impregnated
300
mg
P4,
followed
by
IU
PMSG
injections
48
h
before
CIDR
withdrawal.
Blood
collected
detect
level
hormones
blood
biochemical
indices.
Additionally,
rate,
fecundity
body
weight,
size,
lactation
measured.
results
showed
markedly
decreased
rate
goats.
Among
all
groups,
there
no
substantial
difference
follicle
stimulating
hormone,
luteinising
gonadotropin-releasing
melatonin,
growth
PMSG,
total
cholesterol,
protein,
glucose
levels,
as
well
performance.
Repeated
elevated
estrogen
(E2)
levels
36,
48,
72
post-CIDR
removal;
increased
P4
upon
insertion;
raised
antibody
24,
removal.
suggest
anti-PMSG
are
primary
reason
for
efficiency,
high
E2
at
some
time
points
impair
These
findings
provide
novel
insights
into
effects
stimulation
guiding
future
hormone
use
practices.
Язык: Английский
Type 2 Diabetes Mellitus and Cardiometabolic Prospects: A Rapid Narrative Review
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
Cardiometabolic
syndrome
(CMS),
type
2
diabetes
mellitus
(T2DM),
and
cardiovascular
diseases
are
among
the
major
altruists
to
international
liability
of
disease.
The
lifestyle
dietary
changes
attributable
economic
growth
have
resulted
in
an
epidemiological
transition
towards
non-communicable
(NCDs)
as
leading
causes
death.
Low-
middle-income
countries
(LMICs)
bear
a
more
substantial
disease
burden
due
limited
healthcare
sector
capacities
address
rapidly
growing
number
chronic
patients.
purpose
this
narrative
review
paper
was
explore
interrelationships
between
CMS,
T2DM,
impairments
context
NCDs,
well
preventative
control
interventions.
role
insulin
resistance,
hyperglycemia,
dyslipidemia
pathogenesis
T2DM
development
severe
highlighted.
This
elaborated
on
pivotal
modifications,
such
healthy
diets
physical
activity,
cornerstones
addressing
epidemics
metabolic
diseases.
Foods
high
calories,
refined
sugar,
red
meat,
processed
ready-to-eat
meals
were
associated
with
amplified
risk
CMS
T2DM.
In
contrast,
based
fruits,
legumes,
vegetables,
whole
grain,
home-cooked
foods
demonstrated
protective
effects
against
Additionally,
psychological
behavioral
approach
highlighted,
especially
regarding
its
impact
patient
empowerment
patient-centered
therapeutic
Язык: Английский
The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations
International Journal of Obesity,
Год журнала:
2024,
Номер
49(2), С. 278 - 285
Опубликована: Окт. 17, 2024
This
cross-sectional
study
aims
to
assess
the
associations
between
serum
leptin,
adiponectin,
leptin-to-adiponectin
ratio
(L/A
ratio),
and
metabolic
syndrome
(MS)
HOMA-IR
in
five
African-origin
populations:
Ghana,
South
Africa,
Jamaica,
Seychelles,
US.
Clinical
measures
included
glucose,
insulin,
adipokines,
blood
pressure
anthropometric
measures.
MS
was
determined
using
Harmonized
criteria.
The
final
sample
2087
adults.
After
adjusting
for
age,
sex,
fat
mass,
L/A
ratio,
unlike
HOMA-IR,
significantly
associated
with
across
all
sites
(p
<
0.001).
Within
sites,
only
US
0.001)
Africa
0.01),
respectively.
Leptin
0.05)
but
within
0.05).
Similarly,
adiponectin
each
site
separately,
except
Ghana.
Our
suggests
that
individuals
of
African
diaspora
different
geographical
locations
may
differ
determinants
MS.
Future
studies
should
investigate
disparate
relationships
MS,
IS
adipokines
populations.
Язык: Английский