Food and Humanity, Год журнала: 2024, Номер unknown, С. 100476 - 100476
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(4), С. 1153 - 1153
Опубликована: Фев. 18, 2024
Triterpenoids, such as ganoderic acid, and polysaccharides, including β-D-glucans, α-D-glucans, α-D-mannans, are the main secondary metabolites of medicinal fungus Ganoderma lucidum. There is evidence effects acid in hematological malignancies, whose mechanisms involve stimulation immune response, macrophage-like differentiation, activation MAP-K pathway, an IL3-dependent cytotoxic action, induction cytoprotective autophagy, apoptosis. In fact, this compound has been tested twenty-six different human cancer cell types shown anti-proliferative activity, especially leukemia, lymphoma, myeloma lines. Moreover, research clarified capability molecules from lucidum to induce mitochondrial damage acute promyelocytic leukemia cells, without normal mononuclear cells. Active lipids extracted spores have also apoptosis mediated by downregulation P-Akt upregulation caspases-3, -8, -9. Among vivo studies, a study BALB/c mice injected with WEHI-3 leukemic cells suggested that treatment promotes differentiation T- B-cell precursors, phagocytosis PBMCs, NK activity. Our review presents data revealing possibility employing malignancies incorporating it into clinical practice.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10255 - 10255
Опубликована: Сен. 24, 2024
Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma, involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical challenges due to their heterogeneity varied treatment responses. Despite recent advancements in therapies that have improved survival rates, particularly chronic lymphocytic leukemia acute lymphoblastic treatments like chemotherapy stem cell transplantation often disrupt gut microbiota, which can negatively impact outcomes increase infection risks. This review explores complex, bidirectional interactions between microbiota cancer patients with HMs. Gut influence drug metabolism through mechanisms such as production enzymes bacterial β-glucuronidases, alter efficacy toxicity. Moreover, microbial metabolites short-chain fatty acids modulate host immune response, enhancing effectiveness. However, therapy reduces diversity beneficial bacteria, Bifidobacterium Faecalibacterium, while increasing pathogenic bacteria Enterococcus Escherichia coli. These findings highlight critical need preserve during treatment. Future research should focus on personalized microbiome-based therapies, probiotics, prebiotics, fecal transplantation, improve quality life for hematologic malignancies.
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1598 - 1598
Опубликована: Янв. 27, 2024
Osteonecrosis of the jaw is progressive loss and destruction bone affecting maxilla or mandible in patients treated with antiresorptive antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves inflammatory pathway receptor activator nuclear factor NF-kB ligand macrophage colony-stimulating factor, essential for osteoclast precursors survival proliferation acting through its c-Fms. Evidence has shown role non-coding RNAs osteonecrosis this finding might be useful diagnosis since these small could considered as biomarkers apoptotic activity bone. Interestingly, it been proved that miR-29 miR-31-5p, on specific targets such CALCR RhoA, promote programmed-cell death consequently necrosis tissue. Specific long RNAs, instead, have detected both at reduced levels multiple myeloma osteonecrosis, associated suppression osteoblast differentiation, consequences progression lesions. Among genic material, circular capability to modify expression mRNAs responsible inhibition bisphosphonates osteoclastogenesis.
Язык: Английский
Процитировано
3
Advances in genetics, Год журнала: 2024, Номер unknown, С. 237 - 310
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2
Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 9
Опубликована: Апрель 22, 2024
O. gratissimum is one of the most common medicinal plants in every community Nigeria. This plant has been presumed to be useful management diseases including breast cancer, which commonest cancers affecting women globally. Hence, this study aimed computationally investigate phytochemicals present by elucidate their binding dynamics against five selected molecular targets cancer and predict pharmacokinetics properties. Molecular docking, MMGBSA calculation ADMET prediction were used. The results showed that isovitexin highest affinity −9.11 kcal/mol −9.80 for Human Epidermal Growth Factor Receptor 2 (HER2) (EGFR) respectively. Rosmarinic acid −12.15 Phosphatidylinositol 3-kinase (PI3K), Nepetoidin A −9.14 oestrogen receptor (ER), Vitexin −12.90 Progesterone (PR). provided total energy confirmed stability complexes under physiological conditions. profiles top identified would safe oral administration with no hepatoxicity. Overall, isovitexin, vitexin, rosmarinic acid, nepetoidin luteolin among others, as compounds exhibit strong anti-cancer properties cells.
Язык: Английский
Процитировано
2
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2024, Номер 32(9), С. 1389 - 1399
Опубликована: Янв. 1, 2024
Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing capacity of peripheral blood mononuclear cells produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering close association between chronic inflammation cancer development, RSV's immunomodulatory are one way which may inhibit initiation, proliferation, neovascularization, migration. influences generation microtumor environment is key factors progress. In addition immunomodulation, RSV inhibits development expressing anti-oxidant effects, causing cell cycle arrest, stimulating function certain enzymes, activating signaling pathways. The end outcome various forms death, apoptosis, pyroptosis, necroptosis, more, as it observed
Язык: Английский
Процитировано
2
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Сен. 27, 2024
Background In recent years, the prevalence of childhood obesity has escalated alarmingly, posing significant threats to physical and mental well-being children, with an elevated likelihood persisting into adulthood. Notably, investigations have uncovered a profound association between intestinal microbiota, crucial component internal milieu, obesity. Disturbances in microbiota their by-products are now understood be profoundly intertwined evolutionary pathway Bibliometric analysis offers deep understanding current research landscape, so we apply it review emerging trends patterns gut microbiota. Materials methods We conducted rigorous extensive search Web Science (WoS) Core Collection database, spanning years from 1900 2023, analyze scholarly articles pertaining Utilizing VOSviewer, CiteSpace, R package “bibliometrix,” online bibliometric platform ( https://bibliometric.com/ ), delved intricate details hotspots, academic collaborations, within this domain. Results The exhaustive encompassed globe, uncovering cumulative total 1,384 pertinent studies originating 429 nations. results were compelling, revealing influence exerted by United States China specific field research. Furthermore, was observed that volume works is steadily growing year on year. hot topics include “abuse,” “maltreatment,” “adverse experiences,” “students,” “food addiction”. Conclusion This comprehensive meticulous exploration evolving agendas over past two decades. It strives equip researchers thorough key nations, institutions, journals, potential collaborators these specialized fields. Additionally, sheds light frontiers strategic avenues for further exploration, thus serving as invaluable resource scholars delving deeper intricacies microbiome.
Язык: Английский
Процитировано
1
Applied Sciences, Год журнала: 2024, Номер 14(20), С. 9195 - 9195
Опубликована: Окт. 10, 2024
Background: Fenugreek, or Trigonella foenum greacum, is an ancient medicinal plant native to the eastern Mediterranean that later spread Asia; it used as a herb, spice, food. It component of spice mixes, such curry, and also supplement in wheat corn flour for bread making. Fenugreek appears have many health benefits potential properties; this reason, increasingly being nutraceutical formulations. This study aimed describe patients who visited our operative unit suspected adverse reaction after ingestion fenugreek highlight possible cross-reactivity between other legumes foods. Methods: A total 13 (5 males 8 females; mean age: 30.6; range: 20–42 years) outpatient clinic with clinical history suggestive allergic spices legumes. They underwent skin prick test fenugreek, fresh foods, food extracts. Results: 6 out positive had experienced symptoms ingesting foods containing spices, 10 presented polysensitization legumes, which sensitization pistachios. Conclusions: Given increasing use novel cuisine fenugreek-based nutraceuticals, relevant draw attention reactions. Further studies are needed be able establish its pattern.
Язык: Английский
Процитировано
1
Enfermería Investiga, Год журнала: 2024, Номер 9(1), С. 1 - 4
Опубликована: Янв. 3, 2024
La microbiota intestinal es el conjunto de microorganismos (virus, arqueas, hongos y protozoos) (1), que habitan en intestino humano conformados por más 100 billones bacterias, con un peso aproximado 1,5 kg (2); distribuida tres grandes grupos según sus funciones: bacterias patógenas cantidades muy bajas controladas sistema inmunitario, comensales benéficos patógenos sensibles (3). Por otra parte su estructura comprende mas 200 cepas bacterianas pertenecen a familias: Firmicutes Actinobacterias son Gram positivas los Bacteroidetes Gran negativos (4,5). Se ha reportado del 90% las corresponden filos El filo incluye varios géneros, siendo frecuente Lactobacillus, Enterococcus Ruminiciccus Clostridium. En abundante género Bifidobacterium (6). Al momento nacer, estéril se coloniza completamente durante primer año vida. Entre factores la modulan encuentra tipo parto lactancia materna, posteriormente, influenciada genética, dieta, ambientales, entre ellos, uso antibióticos (4,7). Cada persona presenta una única, ejemplo adulto, dieta inadecuada, abuso o proceso envejecimiento, puede favorecer disbiosis determinada alteración población bacteriana, cual ser cualitativa (predominio especies distintas habituales) cuantitativa (menor concentración beneficiosas) (4).
Процитировано
0
Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Авг. 24, 2024
The current study evaluates hot water A. milleri sunflower extracts at 40 °C temperature (AMSE40) for their antibacterial, anti-biofilm, antiviral and anticancer activities. AMSE40 exhibited excellent antioxidant activity with an IC50 of 1.17 mg/mL (ascorbic acid) was found to be rich in phytochemical compounds such as alkaloids, flavonoids, phenolics, saponins, tannins, concentrations 1.23%, 351.60 mg/g, 152.50 0.98%, 146.35 respectively. showed strong antibacterial anti-biofilm against four multidrug-resistant isolates, comprising E. faecalis, S. aureus, P. aeruginosa, K. pneumonia minimum bactericidal (25 mg/mL) inhibitory (12.5 all isolates. (62.5 µg/mL) efficacy CoxB4 (9.1%) HSV-1 (34.4%). Additionally, induced DNA fragmentation liver cell lines, indicating death. cytotoxic concentration had a mild impact on Vero (283.2 µg) HepG2 cells (76.4 µg). has the potential serve natural eco-friendly source innovative pharmaceutical medical applications.
Язык: Английский
Процитировано
0