Plant-Derived Epi-Nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents DOI Open Access
Rosita Gabbianelli, Ehud Shahar, Gaia de Simone

и другие.

Nutrients, Год журнала: 2023, Номер 15(22), С. 4719 - 4719

Опубликована: Ноя. 8, 2023

Although the COVID-19 pandemic appears to be diminishing, emergence of SARS-CoV-2 variants represents a threat humans due their inherent transmissibility, immunological evasion, virulence, and invulnerability existing therapies. The affected more than 500 million people caused over 6 deaths. Vaccines are essential, but in circumstances which vaccination is not accessible or individuals with compromised immune systems, drugs can provide additional protection. Targeting host signaling pathways recommended genomic stability resistance barriers. Moreover, targeting factors allows us develop compounds that effective against different viral as well newly emerging virus strains. In recent years, globe has experienced climate change, may contribute spread infectious diseases through variety factors. Warmer temperatures changing precipitation patterns increase geographic range disease-carrying vectors, increasing risk spreading new areas. Climate change also affect vector behavior, leading longer breeding season sites for disease vectors. disrupt ecosystems, bringing closer wildlife transmits zoonotic diseases. All above accelerate epidemics. Plant-derived products, have been used traditional medicine treating pathological conditions, offer structurally novel therapeutic compounds, including those anti-viral activity. addition, plant-derived bioactive substances might serve ideal basis developing sustainable/efficient/cost-effective alternatives. Interest herbal antiviral products increased. More 50% approved originate from sources. diverse structures molecules candidates drug development. Combining these therapies conventional could improve patient outcomes. Epigenetics modifications genome gene expression without altering DNA sequences. Host cells use epigenetic regulation mechanism silence incoming molecules, while viruses recruit cellular epitranscriptomic (covalent RNAs) modifiers translational efficiency transcript transcripts enhance replication. manipulate cells' machinery ensure productive infections. Environmental factors, such natural influence modifications. this review, we explore potential broad-spectrum activity, reviewing modulation processes effects on RNA viruses, addressing future research objectives rapidly field.

Язык: Английский

Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods DOI Creative Commons
Marina Ramal-Sánchez,

Chiara Bravo-Trippetta,

Veronica D’Antonio

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

Introduction Immunonutrition, defined as the potential of foods, nutrients and dietary patterns to modulate immune system activity, has been proposed a strategy enhance response in both metabolic immune-mediated diseases. However, anti-/pro-inflammatory role foods diets is far be fully ascertained, thus there continued needed for appropriate vitro cell-culture models investigate modulating cell-mediated inflammatory processes. This study aims develop test an tri-culture model, simulating complexity intestinal tract its multiple cell interactions. Methods To achieve this, epithelial barrier was established by co-culturing human Caco-2 enterocyte-like HT29-MTX-E12 mucus producing goblet-like colon cells, then adding monocyte THP-1 cells basolateral compartment. The integrity stability were monitored model assessed using various stressors at different concentrations, individually combination (phorbol-12- myristate-13-acetate or PMA, lipopolysaccharide LPS), terms cytokines production. concentrations digested broccoli (BD) added apical section model. Results Supernatants from compartment collected analyzed production (IL-6, TNF-α, IL-12p70, IL-18 IL-8) automated ELISA (ELLA). Additionally, ZO-1 protein tight junctions flow cytometry. results indicated that 100 nM PMA whole 20 h best stressor simulate mild-inflammatory status gut. Following treatment with BD, IL-6, IL-8 significantly reduced compared control group, while expression increased lowest BD concentration. Conclusions These findings confirm feasibility assessing effects food digesta on specific permeability markers, representing valuable investigating response. obtained may support strategies aimed promoting wellbeing preventing inflammatory-related

Язык: Английский

Процитировано

1
Plant-Derived Epi-Nutraceuticals as Potential Broad-Spectrum Anti-Viral Agents DOI Open Access
Rosita Gabbianelli, Ehud Shahar, Gaia de Simone

и другие.

Nutrients, Год журнала: 2023, Номер 15(22), С. 4719 - 4719

Опубликована: Ноя. 8, 2023

Although the COVID-19 pandemic appears to be diminishing, emergence of SARS-CoV-2 variants represents a threat humans due their inherent transmissibility, immunological evasion, virulence, and invulnerability existing therapies. The affected more than 500 million people caused over 6 deaths. Vaccines are essential, but in circumstances which vaccination is not accessible or individuals with compromised immune systems, drugs can provide additional protection. Targeting host signaling pathways recommended genomic stability resistance barriers. Moreover, targeting factors allows us develop compounds that effective against different viral as well newly emerging virus strains. In recent years, globe has experienced climate change, may contribute spread infectious diseases through variety factors. Warmer temperatures changing precipitation patterns increase geographic range disease-carrying vectors, increasing risk spreading new areas. Climate change also affect vector behavior, leading longer breeding season sites for disease vectors. disrupt ecosystems, bringing closer wildlife transmits zoonotic diseases. All above accelerate epidemics. Plant-derived products, have been used traditional medicine treating pathological conditions, offer structurally novel therapeutic compounds, including those anti-viral activity. addition, plant-derived bioactive substances might serve ideal basis developing sustainable/efficient/cost-effective alternatives. Interest herbal antiviral products increased. More 50% approved originate from sources. diverse structures molecules candidates drug development. Combining these therapies conventional could improve patient outcomes. Epigenetics modifications genome gene expression without altering DNA sequences. Host cells use epigenetic regulation mechanism silence incoming molecules, while viruses recruit cellular epitranscriptomic (covalent RNAs) modifiers translational efficiency transcript transcripts enhance replication. manipulate cells' machinery ensure productive infections. Environmental factors, such natural influence modifications. this review, we explore potential broad-spectrum activity, reviewing modulation processes effects on RNA viruses, addressing future research objectives rapidly field.

Язык: Английский

Процитировано

2