Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus DOI Creative Commons
Ya Tu, Ming Tan, Yao Li

и другие.

Brain and Behavior, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 31, 2024

ABSTRACT Introduction Depression is a prevalent and significant psychological consequence of traumatic brain injury (TBI). Ferroptosis, an iron‐dependent form regulated cell death, exacerbates the neurological damage associated with TBI. This study investigates whether nicorandil, potassium channel opener nitrate‐like properties known for its antioxidative neuroprotective effects, can mitigate depression‐like behaviors following TBI by modulating ferroptosis. Methods A controlled cortical impact (CCI) device was used to establish model. Depression‐like in rats were assessed using sucrose preference test (SPT), tail suspension (TST), forced swimming (FST). The antioxidant system, lipid peroxidation, ferroptosis levels evaluated. SLC7A11/GPX4 axis analyzed quantitative real‐time PCR (qRT‐PCR) Western blot analysis. Results Nicorandil administration significantly ameliorated also effectively restored substantially reduced attenuated hippocampus Mechanistically, nicorandil promoted Crucially, knockdown hippocampal SLC7A11 abrogated protective effects on behaviors, Conclusion These findings indicate that ameliorates inhibiting through activation axis.

Язык: Английский

The Relationship between Post-Traumatic Stress Disorder Due to Brain Injury and Glutamate Intake: A Systematic Review DOI Open Access
Benjamin F. Gruenbaum, Alexander Zlotnik, Анна Олешко

и другие.

Nutrients, Год журнала: 2024, Номер 16(6), С. 901 - 901

Опубликована: Март 21, 2024

There is a growing body of evidence that suggests connection between traumatic brain injury (TBI) and subsequent post-traumatic stress disorder (PTSD). While the exact mechanism unknown, we hypothesize chronic glutamate neurotoxicity may play role. The consumption dietary modifiable factor influencing levels in blood and, therefore, brain. In this systematic review, explored relationship development post-TBI PTSD. Of 1748 articles identified, 44 met inclusion criteria for analysis review. We observed individuals from countries with diets traditionally high had greater odds developing PTSD after TBI (odds ratio = 15.2, 95% confidence interval 11.69 to 19.76, p < 0.01). These findings support hypothesis chronically elevated concentrations caused by intake invoke neurodegeneration processes could ultimately result Further studies will clarify whether lowering via diet would be an effective strategy preventing or treating

Язык: Английский

Процитировано

5
Efficacy of Astragalus membranaceus–Carthamus tinctorius in Cerebral Ischemia/Reperfusion Injury: Insights from Metabolomics and Mass Spectrometry Imaging DOI
Di Zhao, Xian Zhang, Weifeng Jin

и другие.

Phytomedicine, Год журнала: 2024, Номер 133, С. 155881 - 155881

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

5
The role of isolated diffuse axonal brain injury on post-traumatic depressive- and anxiety-like behavior in rats DOI Creative Commons
Анна Олешко, Benjamin F. Gruenbaum,

Vladislav Zvenigorodsky

и другие.

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Март 31, 2025

Traumatic brain injury (TBI) is a significant global health concern and associated with short-term long-term comorbidities such as mood disorders reduced quality of life. Diffuse axonal (DABI) common but severe type TBI. The role DABI in the development psychiatric sequelae after TBI not well understood due to challenge isolating from general human population. Here we investigate occurrence post-TBI depressive- anxiety-like behaviors rat model. Forty rats were randomly assigned two groups, 20 receiving sham treatment. We used magnetic resonance imaging (MRI) protocol developed for using 3-T clinical scanner confirm DABI. then compared neuroimaging, neurological behavioral assessments across experimental groups. There was difference between groups on sucrose preference, measurement depressive-like behavior (p < 0.012), time spent open arms plus maze test, 0.032). For MRI-detected injury, there diffusion-weighted relative anisotropy 0.001) fractional mapping. found that isolated our model led post-traumatic 30% cases 35%. Additionally, established diagnostic cut-offs injured rats. also documented comorbidity depression anxiety DABI-exposed anticipate this study will greatly enhance understanding relationship DABI, TBI, like anxiety, aid developing treatment options these interconnected conditions.

Язык: Английский

Процитировано

0
Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia DOI Open Access
Wirginia Krzyściak, Beata Bystrowska, Paulina Karcz

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2294 - 2294

Опубликована: Фев. 15, 2024

Given its polygenic nature, there is a need for personalized approach to schizophrenia. The aim of the study was select laboratory biomarkers from blood, brain imaging, and clinical assessment, with an emphasis on patients’ self-report questionnaires. Metabolomics studies serum samples 51 patients 45 healthy volunteers, based liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS), led identification 3 biochemical indicators (cortisol, glutamate, lactate) These metabolites were sequentially correlated tests results, imaging assessment outcomes, including patient outcomes. hierarchical cluster analysis principal components (HCPC) performed identify most homogeneous groups. Significant correlations noted between blood lactates 11 10 neuroimaging parameters. increase in lactate cortisol significantly associated decrease immunological parameters, especially level reactive lymphocytes. strongest demonstrated by N-acetylaspartate concentrations glutamate glutamine, creatine phosphocreatine prefrontal cortex. search associations parameters self-reported outcomes may provide new diagnostic evidence specific schizophrenia phenotypes.

Язык: Английский

Процитировано

2
FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury DOI Creative Commons

Xuekang Huang,

Ziyu Zhu,

Mengran Du

и другие.

NeuroMolecular Medicine, Год журнала: 2024, Номер 26(1)

Опубликована: Июнь 12, 2024

Abstract Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-related depression is not yet clear. Previous studies have suggested FMOD as a potential key factor TBI, its association with post-TBI and underlying mechanisms are well understood. Serum levels were measured patients using qPCR. The severity was assessed self-depression scale (SDS). Neurological function, depressive state, cognitive function mice modified Severity Score (mNSS), forced swimming test (FST), tail suspension (TST), Sucrose Preference Test (SPT), morris water maze (MWM). morphological features mouse hippocampal synapses neuronal dendritic spines revealed through immunofluorescence, transmission electron microscopy, Golgi-Cox staining. protein expression FMOD, MAP2, SYP, PSD95, phosphorylation PI3K/AKT/mTOR signaling pathway, detected Western blotting. decreased TBI patients’ serum. Overexpression preserved alleviated depression-like behaviour, increased synaptic expression, induced ultrastructural changes neurons. PI3K, AKT, mTOR involvement pathway FMOD’s protective effects. exhibits therapeutic target for related to effects potentially mediated pathway.

Язык: Английский

Процитировано

2
Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity DOI Open Access
Benjamin F. Gruenbaum, Kiran S. Merchant, Alexander Zlotnik

и другие.

Nutrients, Год журнала: 2024, Номер 16(24), С. 4405 - 4405

Опубликована: Дек. 22, 2024

The gut–brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting effect brain particularly context depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing bioavailability predisposing to neuroinflammation neurotoxicity. Additionally, we examine metabolites their influence blood–brain barrier neurotransmitter systems involved mood regulation. therapeutic potential microbiome-targeted interventions, such as fecal transplantation, is also highlighted. While much research has explored major depressive disorders other diseases, contribution post-neurological remains underexplored. Future should focus explaining mechanisms linking outcomes, conditions post-stroke depression, post-traumatic brain-injury epilepsy-associated Systematic reviews human clinical studies are needed establish causal relationships assess efficacy therapies improving sequalae after

Язык: Английский

Процитировано

2
The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis DOI
Mani Ratnesh S. Sandhu,

Antonia Schonwald,

Matthew Boyko

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105952 - 105952

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Evaluation of Blood–Brain Barrier Disruption Using Low- and High-Molecular-Weight Complexes in a Single Brain Sample in a Rat Traumatic Brain Injury Model: Comparison to an Established Magnetic Resonance Imaging Technique DOI Open Access

Vladislav Zvenigorodsky,

Benjamin F. Gruenbaum, Ilan Shelef

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11241 - 11241

Опубликована: Окт. 19, 2024

Traumatic brain injury (TBI), a major cause of death and disability among young people, leads to significant public health economic challenges. Despite its frequency, treatment options remain largely unsuitable. However, examination the blood–brain barrier (BBB) can assist with understanding mechanisms dynamics dysfunction, which affects TBI sufferers secondarily injury. Here, we present rat model focused on two standard BBB assessment markers, high- low-molecular-weight complexes, in order understand disruption. In addition, tested new technique evaluate disruption single set, comparing neuroimaging. A total 100 Sprague–Dawley rats were separated into following five groups: naive (n = 20 rats), control administration 60 rats). Rats assessed at different time points after measure using low- high-molecular-weight complexes. Neurological severity score was evaluated baseline 24 h TBI. During neurological exam TBI, scanned magnetic resonance imaging euthanized for permeability. We found that markers displayed examples same set tissues over period week. Our innovative protocol assessing permeability complexes showed appropriate results. Additionally, determined lower limit sensitivity, therefore demonstrating accuracy this method.

Язык: Английский

Процитировано

0
Nutritional Support for Mental Health in TBI Patients DOI

Jia Whei See

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Exploring causal relationship of traumatic brain injury and comorbidities: A Mendelian randomization study DOI Creative Commons
Xiaohang Zhang,

Wenze Wu,

Yaqing Mao

и другие.

Journal of Alzheimer s Disease Reports, Год журнала: 2024, Номер 8(1), С. 1670 - 1676

Опубликована: Июль 1, 2024

Previous observational studies demonstrated a link existed between traumatic brain injury (TBI) and cerebral disease multisystem complications, such as dementia, pneumonia, gastrointestinal disease, but they could be confused by confounding reverse causality. We aimed to figure out the causal correlation TBI following complications. Database concerning complications from genome-wide association study (GWAS) two-sample Mendelian randomization (MR) analysis was employed examine whether causally associated with risk of some All carried through R, version 4.3.3. MR analyses indicated that any dementia has promotional effect on (OR = 1.067, 95% CI, 1.011-1.123, p 0.017). However, there no genetically Alzheimer's (AD), Parkinson's (PD), or disease. Contrary studies, our results uncovered little PD, AD, depression, diseases. Interestingly, we found might TBI, which new discovery.

Язык: Английский

Процитировано

0