Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 31, 2024

Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.

Язык: Английский

---

Treatment with 5-MTHF to support the one-carbon cycle can overcome the deleterious impact of a triple SNP mutation in the male partner’s MTHFR gene for a couple with a history of repeated miscarriage

Journal of Assisted Reproduction and Genetics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

---

Maternal Folate and Vitamin B 12 Concentrations During Pregnancy Influence Neonatal Nutritional Status and Adiposity: Results from the OBESO Cohort

Nutrients, Год журнала: 2025, Номер 17(3), С. 372 - 372

Опубликована: Янв. 21, 2025

Background/Objectives: Folate and B12, among other B vitamins, are methyl donors contribute to multiple DNA methylation processes. Maternal deficiency of these nutrients may be associated with impaired fetal growth, affecting the nutritional status adiposity newborn. This study aimed describe maternal folate B12 throughout pregnancy evaluate its association neonatal status. Methods: We studied 90 healthy pregnant women their babies from prospective OBESO cohort (Mexico City). Serum concentrations were measured (ELISA) in first third trimesters pregnancy. Deficiency was considered if serum <4 ng/mL, red blood cell (RBC) < 151 active 40 pmol/L, total 203 pg/mL). supplementation recorded. Newborn assessment (24–72 h) included weight (BW), length (L), waist circumference (WC), fat mass percentage (%FM; air-displacement plethysmography). indexes computed interpreted (BMI/age length/age) (term-WHO, preterm-Intergrowth). Mean differences, correlations, linear logistic regressions performed (SPSS v. 29). Results: One-third had vitamin at end pregnancy; no observed. High doses for both folic acid identified trimester (2057.04 ± 2100.74 μg/d 7.35 4.56 μg/d). Higher first- third-trimester predicted higher WC reduced risk LBW. first-trimester Thcy levels increased stunting. WC; latter FM% birth. Conclusions: folate, influence newborn alterations, including markers. It is vital guarantee an optimal balanced B-complex

Язык: Английский

---

Adverse Effects of Excessive Folic Acid Consumption and Its Implications for Individuals With the Methylenetetrahydrofolate Reductase C677T Genotype

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

This scoping review examines the risks of high folic acid supplementation in expectant mothers, particularly those with methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism. While is essential for DNA synthesis and preventing neural tube defects, excessive intake may pose health risks, especially individuals MTHFR variant. These have a reduced ability to process acid, leading accumulation unmetabolized (UMFA), which associated vitamin B12 deficiency, cognitive psychiatric issues, adverse pregnancy outcomes. emphasizes importance monitoring explores alternative supplements such as 5-MTHF or 5-FTHF, mitigate these by bypassing conversion. Personalized nutrition, considering genetic variations, crucial optimizing minimizing potential harm.

Язык: Английский

---

Association between serum cotinine concentrations on red blood cell folate concentrations in pregnant women and the mediating role of lymphocytes: an NHANES Study

Archives of Public Health, Год журнала: 2025, Номер 83(1)

Опубликована: Фев. 21, 2025

Folate is essential for DNA synthesis and cell division, particularly during pregnancy, where insufficient levels can lead to adverse outcomes like neural tube defects preterm birth. Tobacco smoke exposure, indicated by serum cotinine levels, a known risk factor reduced folate levels. However, the mechanisms underlying this relationship, especially role of lymphocytes, are not well understood. This study evaluates relationship between RBC concentrations in pregnant women, explores mediating lymphocyte count, identifies susceptibility factors that could guide targeted interventions. We conducted cross-sectional analysis using NHANES data from 1999 2018, including 1,021 women. Serum were used as biomarker tobacco while long-term status. Linear regression, restricted cubic spline, mediation analyses performed assess these relationships. significantly negatively correlated with (P < 0.001). A nonlinear revealed more pronounced depletion at higher Mediation showed elevated count mediated 19.3% cotinine-folate association. Factors such smoking history, advanced maternal age, heavy alcohol consumption exacerbated negative effect. exposure(as reflected levels) reduces playing role. These findings underscore need public health interventions mitigate tobacco-related risks pregnancy.

Язык: Английский

---

The Effect of a specific Vitamin Supplement containing L-methylfolate (Ocufolin forte) in Patients with Neovascular Age-Related Macular Degeneration

Advances in Ophthalmology Practice and Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Biological, dietetic and pharmacological properties of vitamin B9

npj Science of Food, Год журнала: 2025, Номер 9(1)

Опубликована: Март 13, 2025

Abstract Humans must obtain vitamin B 9 (folate) from plant-based diet. The sources as well the effect of food processing are discussed in detail. Industrial production, fortification and biofortification, kinetics, physiological role humans described. As folate deficiency leads to several pathological states, current opinions toward prevention through discussed. Claimed risks increased intake mentioned analytical ways for measurement folate.

Язык: Английский

---

Elevated red blood cell folate levels are associated with metabolic dysfunction-associated steatotic liver disease: results from NHANES 2017–2020

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Март 20, 2025

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic worldwide. However, role of folate in MASLD remains controversial. This study aimed to investigate association between two indicators [serum and red blood cell (RBC) folate] prevalence using data from 2017–2020 National Health Nutrition Examination Survey (NHANES). Methods A total 3,879 participants without or significant alcohol consumption were included final analysis. Hepatic steatosis was assessed via transient elastography, with defined as a controlled attenuation parameter (CAP) ≥285 dB/m presence at least one cardiometabolic risk factor. Logistic regression generalized additive models (GAMs) used evaluate associations levels MASLD, subgroup analyses stratified by age, gender, body mass index (BMI). Results After full adjustment for confounders, RBC exhibited positive (OR = 1.111 95% CI: 1.015–1.216 per 1-unit increase). In contrast, serum showed negative minimally adjusted 0.869 0.802–0.941), which disappeared after further adjustments. Subgroup confirmed that BMI did not modify folate–MASLD relationship. Discussion These findings suggest elevated are independently associated prevalence, whereas may lack clinical relevance due susceptibility confounding factors. folate, stable biomarker long-term status, serve superior indicator investigating associations.

Язык: Английский

---

Dietary nutrient intake and cancer presence: evidence from a cross-sectional study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 1, 2025

Background While the role of specific nutrients in cancer is established, associations between comprehensive dietary nutrient intake and presence remain underexplored. This cross-sectional study investigates global profiles relation to solid blood cancers. Methods A total 42,732 mobile adults from National Health Nutrition Examination Survey (NHANES, 2001–2023) were enrolled this study. The potential intakes 34 4 common trace components with investigated by weighted logistic regression restricted cubic spline. Results Higher saturated fatty acid (OR = 1.1082, 95% CI: 1.0110–1.2146), β -carotene 1.0431, 1.0096–1.0777) vitamin K 1.0370, 1.0094–1.0654) was positively associated overall presence, while phosphorus 0.9016, 0.8218–0.9892) showed a protective association. For tumors, 1.1099), α 1.0353), 1.0484), 1.0405) exhibited positive associations. Retinol linked carcinoma 1.0935, 1.0222–1.1698). Dose–response analyses revealed linear relationships without non-linear thresholds. Conclusion Specific nutrients, notably fats, carotenoids, K, are increased whereas reduced presence. Due nature measurement after diagnosis, causal relationship could not be established. These findings underscore need for longitudinal studies establish causality inform interventions management.

Язык: Английский

---

Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder

Chinese Herbal Medicines, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

---