Genes,
Год журнала:
2024,
Номер
15(12), С. 1562 - 1562
Опубликована: Ноя. 30, 2024
Background/Objectives:
Abnormalities
in
lipid
metabolism
and
endoplasmic
reticulum
(ER)
stress
are
strongly
associated
with
the
development
of
a
multitude
pathological
conditions,
including
nonalcoholic
fatty
liver
disease
(NAFLD),
diabetes
mellitus,
obesity.
Previous
studies
have
indicated
potential
connection
between
thyroid
hormone
responsive
(THRSP)
that
ER
may
participate
synthesis
key
regulators
adipogenesis.
However,
specific
mechanisms
remain
to
be
investigated.
Methods:
In
this
study,
we
explored
roles
THRSP
by
interfering
gene
expression
mouse
mesenchymal
stem
cells,
comparing
effects
on
adipogenesis
control
interfered
groups,
combining
transcriptomic
proteomic
analysis.
Results:
Our
results
showed
number
droplets
was
significantly
reduced
after
THRSP,
levels
adipogenesis,
such
as
LPL,
FABP4,
PLIN1,
CIDEC,
were
downregulated.
Both
differential
genes
(proteins)
enriched
processes
lipolytic
regulation,
stress,
cholesterol
metabolism,
sphingolipid
PPAR
signaling
pathway,
glycerophospholipid
metabolism.
The
marker
gene,
ATF6,
most
downregulated
transcription
factor.
addition,
RT-qPCR
validation
pathway
SCD1;
droplet
generation
LIPE,
DGAT1,
AGPAT2;
ATF6
Conclusions:
These
suggest
is
involved
regulating
which
closely
related
Interfering
helpful
ameliorating
occurrence
diseases
abnormalities
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
31(2)
Опубликована: Дек. 18, 2024
Intrapancreatic
fat
deposition
(IPFD)
has
garnered
increasing
attention
in
recent
years.
The
prevalence
of
IPFD
is
relatively
high
and
associated
with
factors
such
as
obesity,
age,
sex.
However,
the
pathophysiological
mechanisms
underlying
remain
unclear,
several
potential
contributing
factors,
including
oxidative
stress,
alterations
gut
microbiota,
hormonal
imbalances.
was
found
to
be
highly
correlated
occurrence
prognosis
exocrine
pancreatic
diseases.
Although
imaging
techniques
primary
diagnostic
approach
for
IPFD,
an
expanding
array
biomarkers
clinical
scoring
systems
have
been
identified
screening
purposes.
Currently,
effective
treatments
are
not
available;
however,
existing
medications,
glucagon-like
peptide-1
receptor
agonists,
new
therapeutic
approaches
explored
animal
models
shown
considerable
managing
this
disease.
This
paper
reviews
pathogenesis
its
association
diseases,
advancements
diagnosis
treatment,
emphasizing
significant
relevance
IPFD.
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2465 - 2465
Опубликована: Июль 29, 2024
In
this
study,
we
undertook
an
extensive
investigation
to
determine
how
CypB
PPIase
activity
affects
preadipocyte
differentiation
and
lipid
metabolism.
Our
findings
revealed
that
inhibition
of
CypB's
suppressed
the
expression
crucial
proteins
involved
in
adipocyte
induced
changes
regulating
cell
cycle.
Furthermore,
clarified
impact
on
metabolism
via
AKT/mTOR
signaling
pathway.
Additionally,
demonstrated
involvement
through
XBP1s
These
discoveries
offer
invaluable
insights
for
devising
innovative
therapeutic
strategies
aimed
at
treating
averting
obesity
its
related
health
complications.
Targeting
may
emerge
as
a
promising
avenue
addressing
obesity-related
conditions.
our
research
opens
up
opportunities
creating
new
by
enhancing
comprehension
processes
cellular
endoplasmic
reticulum
stress.
Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 26
Опубликована: Окт. 15, 2024
Breast
cancer
(BC)
is
a
major
cause
of
cancer-related
mortality
across
the
globe
and
especially
highly
prevalent
in
females.
Based
on
poor
outcomes
several
limitations
present
management
approaches
BC,
there
an
urgent
need
to
focus
explore
alternate
target
possible
drug
candidates
against
BC.
The
accumulation
misfolded
proteins
subsequent
activation
unfolded
protein
response
(UPR)
alters
homeostasis
endoplasmic
reticulum
(ER)
lumen
that
ultimately
causes
oxidative
stress
ER.
UPR
activates
stress-detecting
such
as
IRE1α,
PERK,
ATF6,
these
sometimes
may
lead
pro-apoptotic
signaling
pathways
cancerous
cells.
ER
stress-dependent
antitumor
activity
could
be
achieved
either
through
suppressing
adaptive
make
cells
susceptible
or
by
causing
chronic
triggering
pathways.
Several
herbal
drugs
trigger
ER-dependent
apoptosis
BC
Therefore,
this
review
discussed
role
fifty-two
their
active
constituents,
focusing
disrupting
balance
within
Further,
challenges
opportunities
have
also
been
BC.Breast
Biotechnology & Biotechnological Equipment,
Год журнала:
2024,
Номер
38(1)
Опубликована: Ноя. 17, 2024
Diacylglycerol
acyltransferase
(DGAT)
plays
a
pivotal
role
in
lipid
metabolism,
particularly
the
biosynthesis
of
triacylglycerols
(TAGs),
which
are
essential
for
energy
storage
and
cellular
membrane
formation.
Xanthoceras
sorbifolium,
commonly
known
as
yellowhorn,
is
notable
high
oil
content
its
seeds
potential
biodiesel
production.
However,
DGATs
have
not
been
thoroughly
studied.
In
this
study,
we
conducted
bioinformatics
analysis
XsDGAT
gene
family
X.
sorbifolium.
The
homologs,
sequence
features,
domain
architecture,
evolutionary
relationships
were
identified,
expression
patterns
across
different
tissues
their
regulatory
elements
XsDGATs
also
displayed,
providing
valuable
insights
into
roles
accumulation.
This
comprehensive
offers
resources
further
experimental
investigations
applications
aimed
at
enhancing
productivity
Genes,
Год журнала:
2024,
Номер
15(12), С. 1562 - 1562
Опубликована: Ноя. 30, 2024
Background/Objectives:
Abnormalities
in
lipid
metabolism
and
endoplasmic
reticulum
(ER)
stress
are
strongly
associated
with
the
development
of
a
multitude
pathological
conditions,
including
nonalcoholic
fatty
liver
disease
(NAFLD),
diabetes
mellitus,
obesity.
Previous
studies
have
indicated
potential
connection
between
thyroid
hormone
responsive
(THRSP)
that
ER
may
participate
synthesis
key
regulators
adipogenesis.
However,
specific
mechanisms
remain
to
be
investigated.
Methods:
In
this
study,
we
explored
roles
THRSP
by
interfering
gene
expression
mouse
mesenchymal
stem
cells,
comparing
effects
on
adipogenesis
control
interfered
groups,
combining
transcriptomic
proteomic
analysis.
Results:
Our
results
showed
number
droplets
was
significantly
reduced
after
THRSP,
levels
adipogenesis,
such
as
LPL,
FABP4,
PLIN1,
CIDEC,
were
downregulated.
Both
differential
genes
(proteins)
enriched
processes
lipolytic
regulation,
stress,
cholesterol
metabolism,
sphingolipid
PPAR
signaling
pathway,
glycerophospholipid
metabolism.
The
marker
gene,
ATF6,
most
downregulated
transcription
factor.
addition,
RT-qPCR
validation
pathway
SCD1;
droplet
generation
LIPE,
DGAT1,
AGPAT2;
ATF6
Conclusions:
These
suggest
is
involved
regulating
which
closely
related
Interfering
helpful
ameliorating
occurrence
diseases
abnormalities
