The Association Between Chronic Liver Disease and Osteoporosis in East Asian Populations: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Zhiyu Wang,

Qi Qu,

Rui Jiang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Abstract Background Chronic liver disease is a widespread health problem globally, particularly common in East Asia. Osteoporosis (OP), as metabolic bone disease, has also gained increasing attention aging societies. In recent years, studies have suggested possible association between chronic and OP, but their causal relationship not been fully or systematically studied. Objective To investigate the OP Asian populations using Mendelian randomization (MR) methods. Methods The datasets for hepatitis B infection (CHB), C (CHC), cirrhosis were sourced from UK Biobank, while those hepatocellular carcinoma (HCC) Japan Biobank. All participants included populations. We first treated exposure outcome MR analysis, then performed reverse analysis treating outcome. inverse variance-weighted (IVW) method was used primary to calculate odds ratios (ORs) 95% confidence intervals (95% CIs). MR-Egger weighted median supplementary approaches assess OP. Heterogeneity pleiotropy tests ensure reliability of results. Results IVW results indicated that CHB (ebi-a-GCST90018584) will increase incidence (bbj-a-137) (OR = 1.063, CI: 1.015–1.112, p 0.009), with no evidence heterogeneity pleiotropy. However, found CHC, cirrhosis, HCC on Reverse analyses did reveal any significant effect disease. Conclusion populations, Therefore, patients only require long-term antiviral treatment protect should monitor over time reduce risk ultimately improving quality life.

Язык: Английский

Linking Reproductive Tract Microbiota to Premature Ovarian Insufficiency: Pathophysiological Mechanisms and Therapies DOI Creative Commons
Xi Zhao, Wenying Shi,

Zhengyu Li

и другие.

Journal of Reproductive Immunology, Год журнала: 2024, Номер 166, С. 104325 - 104325

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

0
Bone Loss and Fractures in Post-Menopausal Women Living with HIV: A Narrative Review DOI Creative Commons

Maryam Jamshaid,

Amirmohammad Heidari,

Ahmed Hassan

и другие.

Pathogens, Год журнала: 2024, Номер 13(9), С. 811 - 811

Опубликована: Сен. 19, 2024

Introduction: Post-menopausal women living with Human Immunodeficiency Virus (WLHIV) face an increased risk of bone fractures due to the relationship between HIV-related factors and menopause. This narrative review aims summarise current knowledge about fracture among post-menopausal WLHIV in particular looking at hormonal changes, combined antiretroviral therapy (cART), lifestyle factors, psychosocial implications. We also profiled a summary significant, recent studies residing low-income countries (LIC). Methods: A thorough search literature was performed across PubMed, Medline, Scopus, Google Scholar, focussing on published 2000 2024. Inclusion criteria entailed original research, reviews, meta-analyses addressing mineral density (BMD), incidence, related WLHIV. Results: The identified 223 relevant studies. exhibit significantly lower BMD higher rates compared both HIV-negative pre-menopausal cART, particularly tenofovir disoproxil fumarate (TDF), contributes reduced BMD. Menopausal status exacerbates this through decreased oestrogen levels, leading resorption. Moreover, choices such as smoking, alcohol consumption, low physical activity are more prevalent PWHIV, which further elevates risk. Different may make WLWHIV vulnerable stage their life, depression, isolation, stigma, housing nutritional issues. Women LICs variety challenges accessing HIV care. There gaps research prevalence osteoporosis loss LICs. Conclusion: effects Antiretroviral (particularly TDF), exacerbate is need for careful selection hormone replacement (HRT), emerging treatments Abaloparatide. holistic approach including changes support crucial reduce WLHIV, especially countries.

Язык: Английский

Процитировано

0
The Importance of Nutrition in Perimenoposal Women DOI

Ferit Ozmaskan

Опубликована: Сен. 4, 2024

Perimenopause is the period when women experience a decline in reproductive abilities and adjust to changes estrogen production. It typically begins mid-40s can last until menopause. During this time, may symptoms such as irregular menstrual cycles, hot flashes, sleep disturbances, mood swings. Menopause confirmed after 12 consecutive months without period.Estrogen deficiency, hormone with extensive metabolic effects, decreases during menopause, leading increased risks of cardiovascular diseases, hormone-sensitive breast cancer, other chronic illnesses. These be mitigated through lifestyle changes.Common perimenopause menopause include night sweats, headaches, joint pain, which vary intensity are influenced by lifestyle.In conclusion, delay development associated alleviate symptoms, improve daily life.

Язык: Английский

Процитировано

0
Effects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial DOI Open Access
Alisa Turbić, Liesbeth Vandenput, Anoohya Gandham

и другие.

Nutrients, Год журнала: 2024, Номер 16(23), С. 4219 - 4219

Опубликована: Дек. 6, 2024

Correction of decreased diversity the gut microbiome, which is characteristic menopause, by supplementation with a synbiotic may attenuate or prevent dysbiosis processes and preserve bone mass. We describe rationale design OsteoPreP trial aimed at evaluating effects 12 months on metabolic health in postmenopausal Caucasian women.

Язык: Английский

Процитировано

0
The Association Between Chronic Liver Disease and Osteoporosis in East Asian Populations: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Zhiyu Wang,

Qi Qu,

Rui Jiang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Abstract Background Chronic liver disease is a widespread health problem globally, particularly common in East Asia. Osteoporosis (OP), as metabolic bone disease, has also gained increasing attention aging societies. In recent years, studies have suggested possible association between chronic and OP, but their causal relationship not been fully or systematically studied. Objective To investigate the OP Asian populations using Mendelian randomization (MR) methods. Methods The datasets for hepatitis B infection (CHB), C (CHC), cirrhosis were sourced from UK Biobank, while those hepatocellular carcinoma (HCC) Japan Biobank. All participants included populations. We first treated exposure outcome MR analysis, then performed reverse analysis treating outcome. inverse variance-weighted (IVW) method was used primary to calculate odds ratios (ORs) 95% confidence intervals (95% CIs). MR-Egger weighted median supplementary approaches assess OP. Heterogeneity pleiotropy tests ensure reliability of results. Results IVW results indicated that CHB (ebi-a-GCST90018584) will increase incidence (bbj-a-137) (OR = 1.063, CI: 1.015–1.112, p 0.009), with no evidence heterogeneity pleiotropy. However, found CHC, cirrhosis, HCC on Reverse analyses did reveal any significant effect disease. Conclusion populations, Therefore, patients only require long-term antiviral treatment protect should monitor over time reduce risk ultimately improving quality life.

Язык: Английский

Процитировано

0