Associations of Essential and Non-Essential Trace Elements’ Levels in the Blood, Serum, and Urine in Women with Premature Ovarian Insufficiency
Biological Trace Element Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Premature
ovarian
insufficiency
(POI)
is
poorly
understood,
with
causes
identified
in
only
25%
of
cases.
Emerging
evidence
suggests
links
between
trace
elements
(TEs)
and
POI.
This
study
the
first
to
compare
concentrations
manganese
(Mn),
copper
(Cu),
zinc
(Zn),
selenium
(Se),
molybdenum
(Mo),
arsenic
(As),
cadmium
(Cd),
mercury
(Hg),
lead
(Pb)
across
urine,
serum,
whole
blood
women
POI
compared
healthy
controls
(HC),
aiming
explore
their
distribution
potential
associations
cross-sectional-case-control
enrolled
81
participants
(40
patients
41
controls)
at
University
Medical
Centre
Ljubljana,
Slovenia.
Blood
urine
samples
were
collected
quantify
basic
biochemical
parameters
using
standard
clinical
chemistry
methods
Mn,
Cu,
Zn,
Se,
Mo,
As,
Cd,
Hg,
Pb
inductively
coupled
plasma-mass
spectrometry
(ICP-MS).
Participants
also
completed
questionnaires
on
socio-demographics,
medical
history,
lifestyle,
nutrition.
Data
was
analyzed
Mann–Whitney
U
test,
Student's
t-tests,
Fisher
exact
logistic
regression
models
adjusted
body
mass
index
(BMI),
age,
hematocrit,
Kendall's
tau
correlation.
Women
had
significantly
higher
BMI
red
cell
(RBC)
indices,
including
hemoglobin,
width
(RDW),
controls.
A
larger
proportion
resided
rural
agricultural
areas.
Liver
kidney
function
assessments
showed
no
significant
differences
groups.
Adjusted
revealed
that
lower
urinary
levels
than
controls,
while
Mn
higher.
Serum
Cu
elevated
patients,
whereas
Pb,
Hg
lower.
No
observed
for
As.
Correlation
analysis
several
strong
moderate
among
TEs
biofluids,
but
weak
correlations
found
demographic
or
factors.
women.
Notably,
most
(Zn,
Pb)
group,
both
serum.
Язык: Английский
Association of Trace Elements with Polycystic Ovary Syndrome in Women—A Case-Control Study
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 79 - 79
Опубликована: Янв. 29, 2025
Objectives:
There
are
still
limited
or
lacking
data
on
the
association
of
trace
elements
(TEs)
with
polycystic
ovary
syndrome
(PCOS).
This
case–control
study
aimed
to
determine
levels
essential
TEs
(manganese
(Mn),
copper
(Cu),
zinc
(Zn),
selenium
(Se),
molybdenum
(Mo))
and
non-essential
(arsenic
(As),
cadmium
(Cd),
mercury
(Hg),
lead
(Pb))
in
urine,
whole
blood,
serum
investigate
a
possible
kidney
liver
function,
endocrine
metabolic
parameters,
environmental
lifestyle
sources
potential
exposure
provide
recommendations.
Methods:
In
our
study,
women
PCOS
(n
=
35)
healthy
controls
underwent
clinical
ultrasonographic
examination,
filled
questionnaires
targeting
general,
lifestyle,
information,
provided
fasting
venous
blood
samples
first
morning
urine
for
biochemical,
hormonal,
TE
analysis.
Multiple
linear
regression
models
were
used
evaluate
between
obtained
through
questionnaires.
Results:
PCOS,
lower
Mo
(p
0.024)
0.011)
higher
Cu
0.026)
detected
when
compared
controls.
Results
this
show
that
amendments
might
be
related
altered
function
disrupted
hormonal
balance
women.
positively
correlated
leukocyte
count.
was
negative
correlation
proteinuria
luteinizing
hormone
levels.
Regarding
negatively
urinary
bilirubin
levels,
there
positive
alanine
aspartate
aminotransferase,
respectively.
Dietary
supplement
consumption
certain
diet
habits
appeared
important
predictors
(beef
consumption)
(cereal
boiled
vegetable
modify
Conclusions:
Concentrations
chemical
biological
appear
nutrition.
To
knowledge,
is
novel
finding
Mo.
Additional
research
needed
more
insights
into
causality
relationship
humans.
Язык: Английский
Evidencias fisiológicas de los mitos menstruales prehispánicos
LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades,
Год журнала:
2025,
Номер
6(1)
Опубликована: Март 4, 2025
La
relación
entre
vida,
mito
y
cultura
es
entendida
como
un
espacio
en
el
que
se
clarifican
los
acontecimientos
de
la
naturaleza
a
partir
diferentes
elementos
proporcionados
por
dichas
narraciones
(
Ramírez
Angarita,
C.,
&
Santos,
C.
R.
2018
),
mitos
resultan
muchas
veces
observaciones
cuidadosas
las
conductas
sociales,
podemos
poner
ejemplo
visiones
prehispánicas
torno
salud,
incluida
menstruación,
buscaban
equilibrio
lo
natural
espiritual,
individuo
comunidad
para
mantener
orden
social
armonía
espiritual.
Dada
importancia
estos
conocimientos,
objetivo
del
trabajo
fue
identificar
estudios
relacionados
con
fisiología
cuatro
creencias
menstruación:
menstruación
sensible
ritmos
cosmos,
sangre
menstrual
poderes
curativos,
regulaciones
conductuales
dependientes
ciclo
salud
reproductiva.
Se
analizaron
veintiún
artículos
condiciones
fisiológicas
cumplían
criterios
observados
incluidos
van
2002
2024.
Entre
ideas
destacar,
encuentra
curativos
sangrado
menstrual,
ahora
conoce
tiene
presentes
células
madre
secretan
altos
factores
angiogénicos
(VEGF,
HGF,
ANG
MMP-1),
citoquinas
proinflamatorias
(L-6,
IL-8
e
IFN-gamma)
antiinflamatorias
(IL-4,
IL10
IL-13)
potencial
regeneración
inmunorregulación.
Evaluation of factors affecting the physiological levels of copper and iron in sheep and cattle in some areas of Diyala Governorate, Iraq.
A. Hussein,
Marah Salim Hameed,
Waleed Ibrahim Jalil
и другие.
PubMed,
Год журнала:
2025,
Номер
15(1), С. 261 - 269
Опубликована: Янв. 1, 2025
Trace
minerals
are
important
components
of
many
physiological
functions,
including
growth,
development,
and
the
immune
response.
This
study
aimed
to
evaluate
copper
iron
status
in
sheep
cattle
some
areas
Diyala
governorate,
Iraq.
One
hundred
blood
samples
were
collected,
50
from
order
measure
levels
serum.
In
sheep,
serum
level
significantly
increased
among
females
compared
males,
while
cattle,
decreased
with
males.
The
showed
a
significant
increase
Serum
age
more
than
1
year
accordingly
at
first
life
or
less
year.
Among
plays
no
role
copper.
pregnant
ewes
non-pregnant.
lambing
non-pregnant
value
was
sheep.
changes
between
cows.
Sheep
Abu
Saida
those
Baqubah
Saadia
cities.
Cows
good
body
scores
have
medium
poor
scores.
There
linear
correlation
studied
parameters
for
cows
affected
by
age,
gender,
pregnancy,
soil
composition.
Язык: Английский
Amphibians and their impact on human reproduction research
F&S Reports,
Год журнала:
2025,
Номер
6, С. 3 - 6
Опубликована: Апрель 1, 2025
Язык: Английский
Engineered immune cell-based therapeutics for female reproductive tract cancers: Advances and future prospects
Journal of Reproductive Healthcare and Medicine,
Год журнала:
2024,
Номер
5, С. 14 - 14
Опубликована: Ноя. 28, 2024
Cancers
of
the
reproductive
tract
are
one
major
causes
deaths
in
women.
The
higher
rate
mortality
among
these
cancers
mainly
due
to
late
stage
disease
detection
and
resistance
existing
drugs.
As
research
progresses,
personalized
medicine,
which
involves
tailoring
treatments
unique
characteristics
each
patient’s
tumor,
is
expected
play
a
significant
role
future.
Engineered
immune
cells
such
as
engineered
dendritic
cells,
chimeric
antigen
receptor
(CAR)
T-cells,
natural
killer
(NK)
have
emerged
an
innovative
approach
cure
female
(FRCs).
These
designed
boost
system’s
ability
identify
remove
cancer
offering
new
therapeutic
opportunities
for
patients
with
limited
treatment
options.
present
review
highlights
applicability
various
cell-based
approaches
treat
FRCs.
It
also
outlines
potential
combining
nanoparticle-based
engineering
strategies
further
enhance
effectiveness
cell
through
improving
delivery
modulators.
Overall,
article
promising
improve
outcomes
Язык: Английский
Nutritional Deficiencies and Subfertility: A Comprehensive Review of Current Evidence
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 8, 2024
Subfertility,
a
condition
marked
by
reduced
capacity
to
conceive
naturally,
affects
significant
proportion
of
couples
globally.
Nutrition
is
fundamental
aspect
reproductive
health,
with
various
nutrients
essential
in
maintaining
optimal
function.
This
comprehensive
review
explores
the
intricate
relationship
between
nutritional
deficiencies
and
subfertility.
It
examines
key
micronutrients
such
as
vitamins
D,
E,
C,
B12,
well
minerals
zinc,
iron,
selenium,
magnesium,
their
impacts
on
fertility.
The
also
considers
macronutrients
importance
balanced
diet
supporting
health.
Drawing
an
extensive
body
clinical
evidence
studies,
this
highlights
how
these
can
lead
hormonal
imbalances,
impaired
gametogenesis,
suboptimal
pregnancy
outcomes.
discusses
efficacy
interventions,
including
dietary
supplements
lifestyle
modifications,
improving
Furthermore,
it
addresses
emerging
research
personalized
nutrition
its
potential
enhance
underscores
necessity
for
healthcare
providers
assess
address
status
patients
provides
practical
recommendations
developing
plans,
counseling
patients,
integrating
interventions
into
fertility
treatments.
By
offering
synthesis
current
evidence,
aims
inform
practice
promote
further
role
enhancing
Язык: Английский
Application of amphiregulin in IVM culture of immature human oocytes and pre-insemination culture for COCs in IVF cycles
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 18, 2024
Background
Amphiregulin
(AR)
is
a
growth
factor
that
resembles
the
epidermal
(EGF)
and
serves
various
functions
in
different
cells.
However,
no
systematic
studies
or
reports
on
role
of
AR
human
oocytes
have
currently
been
performed
reported.
This
study
aimed
to
explore
immature
during
vitro
maturation
(IVM)
fertilization
(IVF)
achieving
better
embryonic
development
provide
basis
for
pre-insemination
culture
medium
specific
cumulus
oocyte
complexes
(COCs).
Methods
First,
we
examined
concentration
follicular
fluid
(FF)
patients
who
underwent
routine
IVF
explored
correlation
between
levels
subsequent
development.
Second,
was
added
IVM
investigate
whether
could
improve
effects
IVM.
Finally,
pioneered
use
supplemented
with
COCs
involvement
can
promote
oocytes,
as
well
Results
A
total
609
FF
samples
were
examined,
positive
blastocyst
formation
observed.
In
our
study,
potential
rate
AR-added
groups,
ameliorated
significantly
compared
control
group
(All
P
<
0.05).
Only
IVM-50
had
higher
than
(P
final
maturation,
fertilization,
high-quality
embryo,
formation,
rates
those
Conclusion
positively
correlated
cultures
effectively
laboratory
outcomes
IVF.
Furthermore,
directly
developmental
at
an
optimal
50
ng/ml.
Язык: Английский
Calcium-phosphorus metabolism and assisted reproductive technologies: intersection points
Russian Journal of Human Reproduction,
Год журнала:
2024,
Номер
30(4), С. 19 - 19
Опубликована: Янв. 1, 2024
Язык: Английский
Circulating micronutrients levels and their association with the risk of endometriosis
Yanna Zhang,
Meng Li,
Feifei Zhang
и другие.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 16, 2024
Background
Endometriosis,
a
prevalent
gynecological
disease,
has
an
unclear
pathogenesis.
Micronutrients
play
crucial
role
in
disease
development,
which
led
to
investigation
of
their
association
with
endometriosis.
Methods
In
this
study,
we
analyzed
the
relationship
between
15
micronutrients
and
endometriosis
using
both
univariate
multivariate
Mendelian
randomization
(MR)
assess
correlation.
The
results
were
validated
high-performance
liquid
chromatography
(HPLC).
Results
MR
analysis
indicated
that
vitamin
B6
(OR
=
1.7060,
95%
CI:
1.1796–2.4672,
p
0.0045)
calcium
1.4834,
1.0747–2.0475,
0.0165)
are
associated
increased
risk
Higher
intakes
greater
likelihood
developing
Egger
regression’s
intercept
term
demonstrated
no
evidence
pleiotropy
(
>
0.05)
or
heterogeneity
(p
SNPs
for
B6.
analysis,
2.397,
1.231–4.669,
0.01)
was
linked
endometriosis,
independently
other
exposure
factors.
No
significant
0.831)
0.369)
observed
genetic
variation
affirming
reliability
analysis.
HPLC
confirmed
increase
serum
levels
calcium,
aligning
findings.
Conclusion
Vitamin
may
be
potentially
acting
as
independent
factor.
Further
research
is
essential
elucidate
offering
novel
insights
prevention
treatment
strategies.
Язык: Английский