The interplay of gut microbiota, obesity, and depression: insights and interventions
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Окт. 30, 2024
Язык: Английский
Effects of candidate genes on milk fat synthesis in ruminants: A meta-analysis
Journal of Dairy Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Phytochemical composition and antidiabetic, anti-obesity, antioxidant, and cytotoxic activities of Carthamus tinctorius seed oil
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 28, 2024
Carthamus
tinctorius
L.
(Safflower)
is
widely
used
in
traditional
Japanese,
Korean,
Chinese,
Arabian,
and
Persian
herbal
medicine
to
treat
metabolic
diseases.
This
study
aimed
characterize
C.
seed
oil
components
estimate
its
inhibitory
effects
on
free
radicals,
porcine
pancreatic
lipase,
α-amylase,
cytotoxic.
To
describe
the
phytochemical
of
oil,
Gas
Chromatography-Mass
Spectrometry
(GC-MS)
technique
was
performed,
while
reference
biochemical
analytical
assays
were
utilized
for
biological
testing.
The
results
showed
that
seven
fatty
acids
accounting
100%
total
identified,
major
acid
linoleic
(79.98
±
0.79%),
followed
by
oleic
(11.20
0.21%)
palmitic
(5.71
0.12%)
acids.
tests
revealed
has
potent
with
IC50
values
13.18
0.07,
43.6
0.09
31.62
0.65
μg/ml,
respectively,
comparison
positive
controls
commercial
drugs
Trolox,
Orlistat,
Acarbose,
which
have
4.1
0.57,
12.88
0.94,
28.18
1.22
respectively.
potential
cytotoxic
against
tested
cancer
cells
lines
a
concentration-dependent
effect
cell
viability.
Given
these
findings,
it
clear
exhibits
DPPH
antilipase,
α-amylase
inhibitory,
properties
controls.
Future
vivo
research
warranted
elucidate
oil's
mechanism
action
decipher
molecular
pathways
involved
anti-obesity,
antidiabetic,
antioxidant,
activities.
Язык: Английский
Metabolomics and network pharmacology reveal partial insights into the hypolipidemic mechanisms of ferulic acid in a dyslipidemia mouse model
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
Introduction
Hyperlipidemia
is
a
condition
characterized
by
abnormal
levels
of
lipids
and
lipoproteins
in
the
plasma,
posing
significant
health
risks.
Ferulic
acid
(FA)
an
organic
with
therapeutic
properties
for
diabetes
hyperlipidemia.
Methods
To
explore
biomarkers
FA
treatment
hyperlipidemia
elucidate
mechanisms
lipid-lowering-related
changes
metabolic
pathways
metabolomics
network
pharmacology.
Initially,
hyperlipidemic
mouse
model
induced
triton
WR-1339
was
established
to
evaluate
effects
FA.
Subsequently,
serum
utilized
identify
differential
metabolites,
pathway
analysis
performed
using
MetaboAnalyst
6.0.
Thirdly,
pharmacology
employed
potential
targets
Finally,
compound-target-metabolite
(C-T-M)
obtained
core
validated
them
molecular
docking.
Results
Biochemical
histological
examination
showed
that
had
lipid-lowering
on
mice.
It
identified
31
against
involving
lipid
amino
metabolism.
Lipid
atherosclerosis
signaling
were
as
key
KEGG
analysis.
Conjoint
associated
18
six
biomarkers.
Molecular
docking
results
has
high
binding
affinity
these
targets.
Discussion
Through
synergy
metabolomics,
this
study
provides
insights
into
how
regulates
endogenous
underscoring
its
promise
Язык: Английский