Dietary Factors and Interventions for Cognitive Impairment and Dementia

Nutrients, Год журнала: 2025, Номер 17(2), С. 210 - 210

Опубликована: Янв. 8, 2025

Nutrition is an important lifestyle factor that can reduce the risk of future cognitive impairment and various neurodegenerative disorders, such as Alzheimer's disease (AD) AD-related dementias (ADRDs) [...].

Язык: Английский

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Simply crushedZizyphi spinosi semenprevents neurodegenerative diseases and reverses age-related cognitive decline in mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 28, 2024

Abstract Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these to remove toxic repair damaged neurons, suppress senescence. As a source such prophylactic agents, we selected Zizyphi spinosi semen (ZSS), medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ tau pathology cognitive impairment mouse models Alzheimer’s disease frontotemporal dementia. Non-extracted simple crush powder showed stronger effects than improved α-synuclein cognitive/motor function Parkinson’s model mice. Furthermore, when administered normal aged mice, suppressed senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression neurogenesis, enhanced cognition levels similar those young The quantity known active ingredients ZSS, jujuboside A, B, spinosin, was not proportional nootropic activity ZSS. These results suggest that promising dietary material prevention neurodegenerative brain aging. Impact statement has only disease-preventing but also brain-rejuvenating

Язык: Английский

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Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Опубликована: Сен. 13, 2024

Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these to remove toxic repair damaged neurons, suppress senescence. As a source such prophylactic agents, we selected Zizyphi spinosi semen (ZSS), medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ tau pathology cognitive impairment mouse models Alzheimer’s disease frontotemporal dementia. Non-extracted simple crush powder showed stronger effects than improved α-synuclein cognitive/motor function Parkinson’s model mice. Furthermore, when administered normal aged mice, suppressed senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression neurogenesis, enhanced cognition levels similar those young The quantity known active ingredients ZSS, jujuboside A, B, spinosin, was not proportional nootropic activity ZSS. These results suggest that promising dietary material prevention neurodegenerative brain aging.Impact statementNon-extracted has only disease-preventing but also brain-rejuvenating

Язык: Английский

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Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Опубликована: Сен. 13, 2024

Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these to remove toxic repair damaged neurons, suppress senescence. As a source such prophylactic agents, we selected Zizyphi spinosi semen (ZSS), medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ tau pathology cognitive impairment mouse models Alzheimer’s disease frontotemporal dementia. Non-extracted simple crush powder showed stronger effects than improved α-synuclein cognitive/motor function Parkinson’s model mice. Furthermore, when administered normal aged mice, suppressed senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression neurogenesis, enhanced cognition levels similar those young The quantity known active ingredients ZSS, jujuboside A, B, spinosin, was not proportional nootropic activity ZSS. These results suggest that promising dietary material prevention neurodegenerative brain aging.Impact statementNon-extracted has only disease-preventing but also brain-rejuvenating

Язык: Английский

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Elucidation of the Anti-Epileptic Effect of Acorus Tatarinowii Schott Based on Brain Metabolomics and Gut Microbiota Analysis

Опубликована: Янв. 1, 2024

Язык: Английский

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