The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier

Nutrients, Год журнала: 2025, Номер 17(5), С. 859 - 859

Опубликована: Фев. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Язык: Английский

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Ultra‐processed foods cause weight gain and increased energy intake associated with reduced chewing frequency: A randomized, open‐label, crossover study

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

To elucidate the effects of ultra-processed foods (UPFs) on body weight and ad libitum energy intake compared with non-UPFs.

Язык: Английский

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Associations between ultra-processed foods intake and preserved ratio impaired spirometry in U.S. adults

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 31, 2025

Preserved Ratio Impaired Spirometry (PRISm) is increasingly recognized as a precursor to Chronic Obstructive Pulmonary Disease (COPD). The impact of Ultra-Processed Foods (UPFs) intake on PRISm and lung function remains underexplored, we aimed explore their associations. This study included 8,336 U.S. adults. Weighted logistic linear regression models were employed for main analysis. Dose-response relationship was examined through restricted cubic spline (RCS) analysis, subgroup analyses explored interactions with selected covariates. Participants in the group older exhibited various adverse health characteristics. percentage total daily energy from UPFs (%Kcal) associated non-significant increase risk (OR 1.67, 95% CI: 0.96-2.92, p = 0.07). However, highest quartile significantly linked increased 1.36, 0.99-1.86, P trend 0.043). Furthermore, higher negatively affected function, participants showing significant reduction forced expiratory volume 1 s (FEV1) -45.5 mL (95% -87.6 -3.4, 0.045) decrease vital capacity (FVC) -139.4 -223.5 -55.4, < 0.001) compared those lowest quartile. RCS analysis demonstrated relationships both function. Subgroup revealed susceptibility primarily among individuals occupational exposure. Additionally, sensitivity indicated that (%Grams) an 1.86, 1.07-3.25, 0.03). Higher affects particularly

Язык: Английский

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Association Between Ultra-Processed Food Intake and Self-Reported Arthritis

American Journal of Preventive Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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A Low Dietary Quality Index in a Newly Diagnosed Inflammatory Bowel Disease Cohort: Results from a Case—Control Study

Nutrients, Год журнала: 2025, Номер 17(6), С. 958 - 958

Опубликована: Март 10, 2025

Background: Epidemiological evidence suggests a link between the risk of IBD and diet. Macro- micro- nutrient intake, diet quality dietary patterns may play pivotal role in disease pathogenesis. We aimed to study intake newly diagnosed patients compared non-IBD controls. Methods: A cohort were invited complete Scottish Collaborative Group Food Frequency Questionnaire (SCGFFQ) at their first clinic visit. Controls recruited from ambulatory patients, university students, healthcare workers. The SCGFFQ estimates habitual over 3-month period. Component data calculated based on previous validation studies, deriving by comparison actual weighted food records. Data age, gender, ethnicity, phenotype collected. macro- micro-nutrients was expressed as mean standard deviation using Kruskal–Wallis test. Dietary derived principal component analysis. Differences for ethnicity analysed logistic regression recommendation values (DRVs) measured index. Results: enrolled 160 cases (114 UC 46 CD) 126 controls, study, with median age across groups 40 years (IQR = 24) UC, 34 29) CD, 36 indexes both CD low controls: 59.0% (SD 18.0) 46.0% 17.7) 63.2% 17.1) had excessive total energy consumption (>2500 kcal/day) DRVs. reported higher retinol, vitamin D, riboflavin, niacin, B6, B12, panthanoic acid consistent rich animal products fruit/vegetable intake. This is likely driven 2 (rich carbohydrates, refined sugar fibre) 5 (refined saturated fat) cohort. pattern 1 (variety items oily fish) less be consumed population. tended have lower overall micro-nutrients. Conclusions: identified here are proof concept, next phase would ideally monitor these case–control prospectively, further understand mechanisms behind which influence IBD. Patients finding supports dietetic attention early CD.

Язык: Английский

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UPFs and Shortened Lifespans: Ultra-Processed Foods Linked to Accelerated Biological Aging; Consequences Across Human Body Systems and Implications for Associated Medical Specialties

Scientia. Technology, science and society., Год журнала: 2025, Номер 2(3), С. 13 - 36

Опубликована: Март 1, 2025

Ultra-processed foods (UPFs) are defined by their high levels of refined carbohydrates, unhealthy fats, artificial additives, and preservatives. These contribute to biological aging through mechanisms such as chronic inflammation, oxidative stress, metabolic dysfunction. Inflammation, disruptions in insulin signaling key factors the development aging-related diseases, including cardiovascular disease, diabetes, neurodegenerative disorders. Specifically, advanced glycation end-products (AGEs) epigenetic modifications significantly acceleration disrupting cellular function, promoting tissue damage, driving disease development. UPF consumption is linked cancer, gastrointestinal disorders, obstetric gynecological conditions, a range adverse effects on various body systems. Reducing intake encouraging healthier dietary patterns crucial for mitigating impact UPFs related health conditions. For individuals unable transition whole food-based diets, pharmaceutical medical interventions offer alternatives reduce UPF-related aging. A combined approach pharmacologic therapies adjustments may optimize outcomes, with ongoing research into novel treatments further enhancing strategies counteract effects. This review examines accelerating aging, which they associated potential mitigate

Язык: Английский

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Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 24, 2025

Background The rising intake of ultra-processed foods (UPFs) has been linked to adverse health outcomes, yet its impact on aging acceleration remains unclear. Objective This study aimed examine the association between percentage total daily calories (%Kcal) and grams (%Gram) from UPFs phenotypic age (PhenoAgeAccel). Methods Data 12,079 adults in NHANES 2005–2010 cycles were analyzed. relationship PhenoAgeAccel was assessed using multivariable linear regression restricted cubic splines, with adjustments for relevant covariates. mediating role body mass index (BMI) also explored. Results A significant positive observed PhenoAgeAccel, highest quartile showing an increase 0.60 (95% CI: 0.15, 1.05; p trend = 0.039), but no found PhenoAgeAccel. Mediation analysis indicated that BMI mediated 27.5% Sensitivity analyses confirmed robustness results. Conclusion Higher is positively associated playing a role.

Язык: Английский

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Exploring the relationship between ultra-processed food consumption and gut microbiota at school age in a Brazilian birth cohort

Cadernos de Saúde Pública, Год журнала: 2025, Номер 41(2)

Опубликована: Янв. 1, 2025

Abstract: Dietary patterns significantly impact health outcomes and gut microbiota composition. However, longitudinal studies associating ultra-processed food consumption with composition, especially among adolescents in low- middle-income countries, are lacking. This study aimed to explore this association using data collected from 364 participants at ages 6, 11, 12 years the 2004 Pelotas (Brazil) Birth Cohort. Microbiota was obtained age after 16S rRNA gene sequencing of self-collected fecal samples. Linear or logistic regression models evaluated relationship between groups (alpha diversity, beta diversity relative abundances phylum genus levels), considering dietary covariates demographic, socioeconomic, health-related, behavioral factors. No significant associations alpha were observed multiple testing corrections, there no strong evidence linking unweighted metrics explaining little variance 11 12. Nominal found Actinobacteria (p = 0.032) Proteobacteria 0.045) (phyla), Bacteroides 0.037 6; p 0.015 11) Peptostreptococcus 0.025 0.010 (genera). these lost statistical significance adjustments for comparisons. These findings highlight need more better understand complex interaction intake composition adolescent populations countries.

Язык: Английский

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The link between ultra-processed food consumption, fecal microbiota, and metabolomic profiles in older mediterranean adults at high cardiovascular risk

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 17, 2025

Ultra-processed food (UPF) consumption has been linked to adverse metabolic outcomes, potentially mediated by alterations in gut microbiota and metabolite production. This study aims explore the cross-sectional longitudinal associations between NOVA-classified UPF consumption, fecal microbiota, metabolome a population of Mediterranean older adults at high cardiovascular risk. A total 385 individuals, aged 55 75 years, were included study. Dietary lifestyle information, anthropometric measurements, stool samples collected baseline after 1-year follow-up. Fecal assessed using 16 S rRNA sequencing liquid chromatography-tandem mass spectrometry, respectively. At baseline, higher was associated with lower abundance Ruminococcaceae incertae sedis (β = - 0.275, P 0.047) concentrations metabolites propionylcarnitine 0.0003, 0.013) pipecolic acid 0.040) feces. Longitudinally, increased reduced Parabacteroides spp. follow-up 0.278, 0.002). High less favorable profiles, suggesting possible link short-chain fatty (SCFA) production, altered mitochondrial energy metabolism, impaired amino metabolism. These findings support reduction promotion dietary patterns rich fiber for better health. Further research is needed confirm these clarify underlying mechanisms. ISRCTN89898870 ( https://doi.org/10.1186/ISRCTN89898870 ).

Язык: Английский

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The Gut–Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12465 - 12465

Опубликована: Ноя. 20, 2024

Myocardial infarction (MI) remains the leading cause of death globally, imposing a significant burden on healthcare systems and patients. The gut-heart axis, bidirectional network connecting gut health to cardiovascular outcomes, has recently emerged as critical factor in MI pathophysiology. Disruptions this including dysbiosis compromised intestinal barrier integrity, lead systemic inflammation driven by gut-derived metabolites like lipopolysaccharides (LPSs) trimethylamine N-oxide (TMAO), both which exacerbate progression. In contrast, such short-chain fatty acids (SCFAs) from balanced microbiota exhibit protective effects against cardiac damage. This review examines molecular mediators considering role factors sex-specific hormones, aging, diet, physical activity, alcohol consumption outcomes. Additionally, we highlight therapeutic approaches, dietary interventions, personalized probiotics, exercise regimens. Addressing axis holds promise for reducing risk improving recovery, positioning it novel target therapy.

Язык: Английский

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