Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11078 - 11078

Опубликована: Окт. 15, 2024

Environmental exposure to a mixture of chemical xenobiotics acts as double-edged sword, promoting or suppressing tumorigenesis and the development breast cancer (BC). Before anything else, we are what eat. In this review, highlight both “the good” bad” sides daily human diet dietary patterns that could influence BC risk (BCR) incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, raw food, increases apoptosis autophagy, antioxidation, cell cycle arrest, anti-inflammation, immune response against cells. Moreover, healthy lead reduction in inhibition genomic instability, stemness, growth, proliferation, invasion, migration, distant metastasis. We also emphasize that, addition beneficial compounds, our food is more contaminated by chemicals with harmful effects, which interact each other endogenous proteins lipids, resulting synergistic antagonistic effects. diverse diet, combined appropriate nutritional behaviors, can exert anti-carcinogenic effects improve treatment efficacy, patient outcomes, overall quality life patients.

Язык: Английский

The role of miRNAs in the extracellular vesicle-mediated interplay between breast tumor cells and cancer-associated fibroblasts

Journal of Cancer Metastasis and Treatment, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

The tumor microenvironment (TME) of breast cancer (BC) is depicted as an immunosuppressive dwelling that comprises a myriad cell types embedded in the extracellular matrix. As one most abundant populations within TME, cancer-associated fibroblasts (CAFs) play indispensable roles increasing aggressiveness and promoting resistance to standard-of-care therapies. Extracellular vesicles (EVs) represent diverse array biological nanoparticles, encompassing exosomes, microvesicles, apoptotic bodies. In recent years, these cell-derived membranous structures have raised great interest they can encapsulate numerous cellular cargo, such proteins, lipids, miRNAs. By transmitting bioactive content recipient cells, EVs pivotal intercellular communication between CAFs cells. secreted from cells typically activate resident acquire myofibroblastic phenotype, while diffused by CAFs, turn, substantially increase progression BC. This review summarizes latest findings highlight functional role EV especially miRNAs, regulatory network. A better understanding EV-mediated cell-cell interactions crucial achieving effective treatment patients with

Язык: Английский

Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1564 - 1564

Опубликована: Ноя. 21, 2024

Background: The aim of this study was to determine the effect Sparstolonin B (SsnB) on cell proliferation and apoptosis in human breast cancer (MCF-7) ovarian epithelial (OVCAR-3) lines presence absence estradiol hemihydrate (ES). Phosphoinositol-3 kinase (PI3K), phosphorylated protein alpha (p-AKT), mTOR (mechanistic target rapamycin) signaling proteins, sphingomyelin/ceramide metabolites were also measured within scope study. Methods: anti-proliferative effects SsnB therapy evaluated over a range times concentrations. Cell determined by measuring Proliferating Nuclear Antigen (PCNA). PCNA quantified ELISA distribution assessed immunofluorescence microscopy. MTT analysis used test vitality cells, while LC-MS/MS analyze amounts ceramides (CERs), sphingosine-1-phosphate (S1P), sphingomyelins (SMs). TUNEL labeling assess apoptosis, staining enzyme-linked immunosorbent assay (ELISA) measure levels PI3K, p-AKT, p-mTOR proteins. Results: administration significantly decreased viability MCF-7 OVCAR-3 cells both ES, it did not cause toxicity healthy fibroblasts. In comparison controls, treated with showed significant drop S1P, p-mTOR. cultured SsnB, increase intracellular concentrations C16-C24 CERs observed. Conclusions: downregulated reducing promoting ceramide buildup apoptosis.

Язык: Английский