Association between vitamin A intake and depression: A cross-sectional study of NHANES from 2005 to 2020 and Mendelian randomization analysis
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Background:
The
association
of
vitamin
A
intake
with
depression
remains
unclear.
This
study
combined
observational
research
and
Mendelian
randomization
(MR)
analysis
to
explore
the
relationship
between
depression.
Methods:
First,
we
performed
a
cross-sectional
utilizing
National
Health
Nutrition
Examination
Survey
(NHANES)
data
from
2005
2020.
Weighted
multivariable
logistic
regressions
restricted
cubic
spline
(RCS)
regression
were
applied
We
also
conducted
stratified
sensitivity
analyses
assess
robustness
results.
Second,
MR
causal
risk
using
publicly
available
Genome-Wide
Association
Studies
(GWAS)
database.
The
inverse-variance
weighted
(IVW)
method
was
our
primary
for
analysis.
In
addition,
multiple
evaluate
reliability
results,
including
Cochran’s
Q
test,
MR-Egger
intercept
regression,
MR-Pleiotropy
Residual
Sum
Outlier
(MR-PRESSO),
leave-one-out
Results:
In
study,
total
38,157
individuals
enrolled.
negatively
associated
after
adjusting
all
covariates
(OR=0.92,
95%CI:
0.88-0.97,
P=0.001).
Similar
inverse
associations
observed
when
converted
into
categorical
variables.
RCS
found
an
L-shaped
nonlinear
dietary
(
P
non-linearity=0.010)
covariates.
Vitamin
consumption
inversely
(OR=0.999,
95%
CI:
0.999-1.000,
P=0.002)
intakes
below
492.00
μg.
contrast,
no
(
P=0.656)
μg
or
higher.
Furthermore,
remained
robust
in
both
analyses.
analysis,
15
single-nucleotide
polymorphisms
(SNPs)
identified
as
instrumental
variables
(IVs).
IVW
significant
(OR=0.39,
0.10-1.58,
P=0.188).
results
method,
median
simple
mode
method.
Sensitivity
confirmed
these
Conclusions:
that
depression,
regardless
whether
measured
continuous
variable.
However,
findings
did
not
indicate
risk.
Язык: Английский
Protective effects of docosahexaenoic acid combined with bilberry extract on myopic Guinea pigs
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 17, 2024
This
study
aims
to
investigate
the
protective
effects
of
docosahexaenoic
acid
(DHA)
combined
with
bilberry
extract
(BE)
on
myopic
guinea
pigs.
In
total,
105
healthy
pigmented
pigs
aged
2
weeks
were
selected
and
randomly
divided
into
five
groups.
The
normal
control
(NC)
group
received
no
treatment,
while
experimental
groups
wore
-6.0D
lenses
right
eye
establish
an
animal
model
lens-induced
myopia
(LIM).
These
further
based
different
treatments:
feeding,
DHA
BE
+
treatment.
Refractive
error
axial
length
for
both
eyes
measured
before
modeling,
after
4
8
Fundus
examination
was
performed,
choroidal
thickness,
vascularity
index
(CVI),
maximal
mixed
response
in
dark
adaptation
(Max-ERG),
cone
cell
light
(Cone-ERG)
measured.
After
we
observed
a
significant
reduction
refractive
shortening
length,
improvement
fundus
condition,
increased
thickness
CVI
LIM
group.
Electroretinogram
(ERG)
showed
that
amplitudes
a-wave
b-wave
enhanced
Max-ERG
Cone-ERG
tests.
exhibited
superior
compared
combination
delayed
progression
more
effective
than
or
alone.
synergistic
effect
offers
new
approach
prevention
treatment
myopia.
Язык: Английский