Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women?
Life,
Год журнала:
2025,
Номер
15(2), С. 277 - 277
Опубликована: Фев. 11, 2025
Irritable
bowel
syndrome
(IBS)
is
a
functional
gastrointestinal
disorder
characterized
by
abdominal
pain,
bloating,
and
altered
habits.
Women
are
disproportionately
affected
IBS
due
to
complex
interplay
between
genetic,
environmental,
psychosocial
factors,
along
with
crucial
role
of
the
gut–brain
axis
in
modulating
both
function
pain
perception.
Evidence
suggests
strong
association
psychological
distress
symptoms.
report
higher
levels
compared
men,
sex
biological
variable
that
shapes
several
aspects
mechanisms,
epidemiology,
clinical
manifestations
IBS.
This
paper
explores
bidirectional
relationship
factors
focus
on
women.
Stress,
anxiety,
depression,
childhood
trauma
contribute
symptomatology,
societal
unique
women
may
exacerbate
this
condition.
Strategies
for
integrated
care
approaches
gender-specific
treatment
strategies
improve
patient
outcomes
quality
life
needed.
Язык: Английский
Exercise, Gut Microbiome, and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms
Gastroenterology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
benefits
of
regular
physical
activity
(PA)
on
disease
prevention
and
treatment
outcomes
have
been
recognized
for
centuries.
However,
only
recently
has
interorgan
communication
triggered
by
the
release
"myokines"
from
contracting
skeletal
muscles
emerged
as
a
putative
mechanism
which
exercise
confers
protection
against
numerous
states.
Cross-talk
between
active
gut
microbiota
reveal
how
PA
boosts
host
immunity,
facilitates
more
diverse
microbiome
functional
metabolome,
plays
positive
role
in
energy
homeostasis
metabolic
regulation.
In
contrast,
despite
large
interindividual
variation
human
microbiome,
reduced
microbial
diversity
implicated
several
diseases
gastrointestinal
(GI)
tract,
systemic
immune
diseases,
cancers.
Although
prolonged,
intense,
weight-bearing
conducted
extreme
conditions
can
increase
intestinal
permeability,
compromising
gut-barrier
function
resulting
both
upper
lower
GI
symptoms,
these
are
transient
benign.
Accordingly,
become
an
attractive
target
modulating
many
effects
health
disease,
although
precise
dose
required
to
induce
favourable
changes
enhance
immunity
is
currently
unknown.
Future
efforts
should
concentrate
gaining
deeper
understanding
factors
involved
exercise-gut
interactions
through
generation
'omics
readouts
(ie,
metatranscriptomics,
metaproteomics,
metabolomics)
that
potential
identify
traits
linked
states,
validating
experimental
preclinical
systems.
A
greater
interacts
with
tract
may
enable
targeted
therapeutic
strategies
be
developed
individuals
populations
at
risk
variety
diseases.
Язык: Английский
Irritable bowel syndrome, the gut microbiome, and diet
Current Opinion in Endocrinology Diabetes and Obesity,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Purpose
of
review
To
provide
an
update
recent
studies
exploring
the
role
gut
microbiota
and
diet
in
pathogenesis
treatment
irritable
bowel
syndrome
(IBS).
Recent
findings
The
human
microbiome
has
been
recognized
as
important,
active
source
signaling
molecules
that
explain
part
disorder
brain
interaction
(DGBI)
IBS.
Subsequent
changes
metabolome
such
production
short-chain
fatty
acids
(SCFA)
serotonin
are
associated
with
IBS
symptoms.
Dietary
components
important
triggers
symptoms
a
low
fermentable
oligo-,
di-,
monosaccharides,
polyols
(FODMAPs)
shown
effective
safe,
even
when
used
long-term.
Fecal
transplantation
(FMT)
not
sustained
symptom
reduction
controlled
clinical
trials.
Summary
This
elucidates
developments
it
relates
to
trial
results
targeting
dietary
interventions.
is
metabolically
affects
bi-directional
gut-brain
axis.
Язык: Английский
From human to superhuman: the impact of the microbiome on physiology
The Journal of Physiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
The
complex
microbial
community
residing
in
the
human
gut
has
long
been
understood
to
regulate
gastrointestinal
physiology
and
participate
digestive
diseases,
but
its
extraintestinal
actions
influences
are
increasingly
recognized.
This
article
discusses
bidirectional
interactions
between
microbiome
athletic
performance,
metabolism,
longevity
ability
of
gut–brain
axis
influence
cognitive
function
mental
health.
image
Язык: Английский
Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment
Gastrointestinal Disorders,
Год журнала:
2025,
Номер
7(1), С. 11 - 11
Опубликована: Янв. 22, 2025
Background:
Chronic
constipation
is
a
well-recognized
complication
which
caused
by
hard
and/or
infrequent
defecation.
According
to
estimates,
presents
as
chronic
illness
affecting
16%
of
adults
globally,
who
deal
with
insufficient
bowel
movements
that
cause
discomfort,
bloating,
or
sensation
incomplete
bowel.
Objectives:
This
review
looks
at
the
many
local
and
systemic
factors
contribute
pathogenesis
causative,
including
dietary
habits,
genetic
factors,
colon
function
absorption,
social
economic
lifestyle,
biological
drug
factors.
Results:
Appropriate
diagnostic
management
modalities
are
cornerstone
in
patients
constipation.
However,
there
still
controversies
regarding
timing
these
approaches.
condition
common
reduces
quality
life
represents
burden
on
any
healthcare
system.
In
clinical
practice,
it
remains
problematic,
physicians
most
time
indecisive
therapy
administer
what
time.
Conclusions:
Constipation
new
topic
was
introduced
over
decade
ago
purpose
this
study
shed
some
light
onto
problems
modern
day
techniques
can
be
used
treat
patients,
primarily
through
behavioural,
conservative,
medical,
surgical
means.
Additionally,
particular
conjunction
an
algorithm
designed
enhance
support
practice.
Язык: Английский
The role of exercise in alleviating irritable bowel syndrome (IBS) symptoms: addressing diagnostic challenges and management shortcomings
Gebrezabher Niguse Hailu,
Meles Mebrahtu Gebremariam,
Hailemariam Atsbeha Meles
и другие.
The Egyptian Journal of Internal Medicine,
Год журнала:
2025,
Номер
37(1)
Опубликована: Фев. 13, 2025
Abstract
Background
Irritable
bowel
syndrome
(IBS)
is
a
prevalent
yet
intricate
gastrointestinal
condition
that
poses
substantial
challenges
in
both
diagnosis
and
treatment.
The
lack
of
definitive
diagnostic
markers
the
focus
on
symptom-based
therapies
often
result
inadequate
relief
for
patients,
leading
to
frustration
psychological
distress.
In
areas
where
access
healthcare
limited,
uncertainty
surrounding
IBS
frequently
drives
patients
explore
alternative
treatments,
including
traditional
medicine,
which
can
potentially
worsen
or
introduce
new
health
risks.
Aim
This
case
report
study
aimed
examine
underappreciated
role
exercise
as
viable
treatment
IBS,
shedding
light
shortcomings
current
therapeutic
practices.
It
provides
an
important
perspective
presents
highly
effective
non-pharmacological
intervention
underutilized
clinical
practice
Ethiopia.
Язык: Английский
Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(5), С. 1708 - 1708
Опубликована: Март 3, 2025
Background/Objectives:
Physical
exercise
can
have
significant
consequences
for
the
gastrointestinal
tract,
which
is
why
there
been
studies
into
its
influence
on
treatment
of
conditions
such
as
colorectal
cancer,
inflammatory
bowel
diseases
(IBD),
and
irritable
syndrome
(IBS),
being
that
epidemiological
evidence
has
a
protective
effect
against
colon
cancer.
This
review
aims
to
demonstrate
mechanisms
action
physical
in
well
benefits
associated
with
digestive
system,
addition
gathering
training
recommendations
treating
different
diseases.
Results:
modulates
motility,
permeability,
immune
responses,
microbiota
composition,
both
beneficial
adverse
effects
depending
intensity
duration.
Regular
moderate
improved
quality
life
IBD
IBS,
reduced
cancer
risk,
potential
symptom
relief
constipation.
However,
high-intensity
may
exacerbate
gastroesophageal
reflux
symptoms
increase
risk
bleeding.
While
aerobic
extensively
studied,
resistance
health
remain
underexplored.
Conclusions:
New
methodologies
techniques,
molecular
biology
study
gastric
receptors,
led
advances
understanding
changes
exercise.
These
cover
intensities
are
investigated
experimental
models
clinical
studies.
Язык: Английский
Endocrine gastroenterological aspects of metabolic dysfunction
Experimental and Clinical Gastroenterology,
Год журнала:
2025,
Номер
9, С. 36 - 43
Опубликована: Март 6, 2025
This
review
article
examines
the
endocrine
gastroenterological
aspects
of
metabolic
dysfunction,
which
is
a
complex
pathological
condition
that
affects
metabolism
and
accompanied
by
disturbances
in
functioning
system.
The
introduction
focuses
on
key
hormones
such
as
insulin
leptin
their
roles
regulating
digestive
processes.
consequences
secretion
these
hormones,
including
development
type
2
diabetes
mellitus
obesity,
are
discussed.
offers
comprehensive
analysis
relationship
between
disruption
problems
irritable
bowel
syndrome,
highlighting
importance
further
research
to
understand
mechanisms
underlying
diseases.
results
this
can
serve
basis
for
new
approaches
diagnosis
treatment
disorders,
well
formation
strategies
prevention
associated
Язык: Английский
Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 328 - 328
Опубликована: Март 10, 2025
Inflammatory
bowel
disease
(IBD)
induces
immunological
and
autonomic
imbalances.
Exercise
is
a
beneficial
strategy
for
controlling
IBD
symptoms.
We
investigated
the
role
of
exercise
on
gastrointestinal
(GI)
motility
changes
parameters
in
rats
with
ileitis.
Rats
were
divided
into
control,
ileitis,
exercise+ileitis
groups.
Ileitis
was
induced
by
TNBS
(40
mM,
intraileally).
The
swimming
(1
h/day/4
weeks,
5%/bw).
assessed
eating
behaviour
oxidative
stress.
Body
composition
bioimpedance.
Autonomic
balance
ECG
measured
an
electrocardiogram
(ECG).
Gastrointestinal
evaluated
using
phenol
red
technique.
In
terms
body
composition,
total
water
(TBW),
mass
index
(BMI),
fat-free
(FFM)
higher
ileitis
group
(216.80
±
11.44
mL;
24.09
2.15
g/cm2;
287.1
14.66
g)
(p
<
0.05)
vs.
control
(130.06
28.23
16.38
2.50
193
42.21
prevented
(91.33
12.33
11.73
0.47
133.8
16.82
these
changes.
reduction
gastric
retention
(11.22
1.91%
35.17
1.01%
33.96
1.77%).
increased
intestinal
duodenum
(46.3
2.56%
24.98
1.78%)
jejunum
(34.22
2.33%
34.72
2.83%
47.32
1.48%)
decreased
ileum
group.
Exercise+ileitis
(24.96
1.66%
46.3
2.56%)
(40.32
3.75%
14.08
0.88%).
high
MDA
levels
(4.43
0.69
0.12
nmol/mg
tissue).
This
effect
(2.75
0.21
4.43
observed
LF
component
(31.32
3.99
43.43
3.86).
correlation
indicated
stronger
interrelationship
between
parameter
(r:
0.68;
p:
0.04).
current
study
suggests
alters
GI
balance,
physical
can
represent
essential
non-pharmacological
approach
to
treatment.
Язык: Английский