The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004
Xu Sun,
Jimei Song,
Ran Yan
и другие.
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 11, 2025
Abstract
Background
The
connection
between
lipid-related
obesity
indices
and
severe
headache
or
migraine
in
young
middle-aged
people
aged
20–60
remains
ambiguous,
there
are
gaps
the
discriminative
ability
of
different
indicators
for
headaches
migraines.
Consequently,
we
set
out
to
look
into
this
association
utilizing
National
Health
Nutrition
Examination
Survey
(NHANES)
data
from
1999
2004.
Methods
After
values
waist-to-height
ratio
(WHtR),
body-mass
index
(BMI),
body
roundness
(BRI),
visceral
adiposity
(VAI),
lipid
accumulation
product
(LAP),
triglyceride
glucose
(TyG),
cardiac
metabolism
(CMI),
waist
Index
(WTI),
conicity
(CI)
weight-adjusted
(WWI)
were
estimated,
with
minimal
sufficient
adjustment
confounders
determined
by
directed
acyclic
graph
(DAG),
weighted
univariable
multivariable
logistic
regression
analyses
carried
ascertain
relationship
them
migraine.
Stratified
analysis
cross-effect
implemented
examine
variability
intergroup
correlations.
Restricted
cubic
splines
(RCS)
receiver
operating
characteristic
(ROC)
then
employed
nonliner
relationships
its
discriminatory
migraine,
respectively.
Results
3354
United
States
adults
involved
our
study,
whom
839
(25.01%)
had
adjusting
relevant
covariables,
WHtR,
BRI,
BMI,
LAP,
WTI
VAI
all
associated
WHtR
(OR
=
6.38,
95%
CI:
2.25,18.09,
P
<
0.01)
showed
best
predictive
ability.
Additionally,
BRI
demonstrated
linear
dose-response
prevalence
(all
overall
0.05,
non−linearity
>
0.05).
Conclusions
Among
those
ten
evaluated
BMI
positive
individuals
within
Our
study
can
provide
important
insight
epidemiological
research
comprehensive
management
obese
patients
Язык: Английский
Hesperetin mitigates adipose tissue inflammation to improve obesity-associated metabolic health
International Immunopharmacology,
Год журнала:
2025,
Номер
149, С. 114211 - 114211
Опубликована: Фев. 9, 2025
Язык: Английский
African minors’ health challenges are comparable to those in the rest of the world
World Journal of Clinical Pediatrics,
Год журнала:
2025,
Номер
14(2)
Опубликована: Март 18, 2025
Today’s
youth
in
rich
and
poor
countries
faces
comparable
health
risks
challenges.
There
is
the
temptation
to
enjoy
too
much
food
that
advertised
as
delicious
eat
little
healthier
food.
An
increasingly
sedentary
lifestyle
makes
physical
activity
voluntary,
no
longer
based
on
daily
need
for
rural
production.
This
a
serious
medical
problem,
today’s
young
people
are
threatened
tomorrow
(and
sometimes,
already
today)
by
cardiovascular
disease
type
2
diabetes
mellitus,
later
further
challenges
including
arthritis,
stroke,
more.
But
this
challenge
far
beyond
medicine.
Young
be
empowered
distinguish
between
good
bad
lifestyles
strengthened
their
willingness
make
an
effort
future
health.
It
may
not
seem
very
sexy
mostly
fruits
high-fiber
traditional
foods
instead
of
hamburgers,
snacks,
sweets,
or
posh
restaurants.
Everyone
needs
certain
resistance
advertising
today,
whether
they
grow
up
Nigeria,
Europe
anywhere
else.
Medical
doctors,
teachers,
many
other
professionals
with
responsibilities
have
key
role
endeavour.
Язык: Английский
Role of metabolic dysfunction-associated fatty liver disease in atrial fibrillation and heart failure: molecular and clinical aspects
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 8, 2025
Metabolic
dysfunction-associated
fatty
liver
disease
(MASLD)
is
a
rising
global
health
concern.
In
addition
to
direct
hepatic
complications,
extra-hepatic
including
cardiovascular
diseases
(CVD),
type
2
diabetes
(T2D),
gastroesophageal
reflux
disease,
chronic
kidney
and
some
malignancies,
are
increasingly
recognized.
CVD,
atrial
fibrillation
(AF)
heart
failure
(HF),
the
leading
cause
of
death
in
patients
with
MASLD.
External
factors,
excess
energy
intake,
sedentary
lifestyle
xenobiotic
use,
induce
inflammation-related
complications.
MASLD,
AF,
HF
associated
immune
system
activation,
reprogramming
cells
establishment
memory.
Emerging
evidence
suggests
that
cross-talk
each
other
through
diverse
spectrum
autocrine,
paracrine
endocrine
mechanisms.
Pro-inflammatory
cytokines
produced
from
circulate
systemically
orchestrate
metabolic
derangements
promote
systematic
dysregulation
heart-liver
axis
development
end-organ
Cardio-hepatic
syndrome
describes
clinical
biochemical
dysfunction
cardiac
pathology
due
interaction
between
liver.
Activation
inflammatory
cascades,
oxidative
stress
underlie
key
mechanisms
bringing
about
such
pathological
changes.
This
review
focuses
on
current
molecular
cross-talk.
It
summarizes
epidemiological
pathophysiological
associations
AF
HF.
addition,
we
will
discuss
how
repurposing
currently
available
emerging
pharmacotherapies
may
help
tackle
risks
resulting
Язык: Английский
Spotlight on the Mechanism of Action of Semaglutide
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 14514 - 14541
Опубликована: Дек. 23, 2024
Initially
intended
to
control
blood
glucose
levels
in
patients
with
type
2
diabetes,
semaglutide,
a
potent
glucagon-like
peptide
1
analogue,
has
been
established
as
an
effective
weight
loss
treatment
by
controlling
appetite.
Integrating
the
latest
clinical
trials,
semaglutide
or
without
diabetes
presents
significant
therapeutic
efficacy
ameliorating
cardiometabolic
risk
factors
and
physical
functioning,
independent
of
body
reduction.
Semaglutide
may
modulate
adipose
tissue
browning,
which
enhances
human
metabolism
exhibits
possible
benefits
skeletal
muscle
degeneration,
accelerated
obesity
ageing.
This
be
attributed
anti-inflammatory,
mitochondrial
biogenesis,
antioxidant
autophagy-regulating
effects.
However,
most
supporting
evidence
on
mechanistic
actions
is
preclinical,
demonstrated
rodents
not
actually
confirmed
humans,
therefore
warranting
caution
interpretation.
article
aims
explore
potential
innovative
molecular
mechanisms
action
restoring
balance
several
interlinking
aspects
metabolism,
pointing
distinct
functions
inflammation
oxidative
stress
insulin-sensitive
musculoskeletal
tissues.
Moreover,
applications
protection
from
infections
anti-aging
properties
are
discussed.
enhancement
core
involved
progress
although
mostly
provide
framework
for
future
research
diseases
overall.
Язык: Английский
A bioinformatics analysis of gene expression in endometrial cancer, endometriosis and obesity
Shan Shibu,
Shrinal Vasa,
S. Samantaray
и другие.
Women & Health,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Дек. 9, 2024
Endometrial
cancer
(EC),
endometriosis
(ENDO),
and
obesity
(OBY)
are
interconnected
conditions
in
women
that
may
share
underlying
genetic
pathways.
This
study
aimed
to
identify
shared
pathways
differential
gene
expressions
across
these
uncover
potential
therapeutic
targets.
A
bioinformatics
pipeline
was
applied
using
expression
datasets
from
the
GEO
database,
incorporating
analysis,
functional
pathway
enrichment,
PPI
network
construction,
survival
mutational
profiling
198
samples.
The
analysis
revealed
26
differentially
expressed
genes
(DEGs),
with
IGF-1,
CREBBP,
EP300,
PIAS1
identified
as
key
hub
genes.
Elevated
IGF-1
significantly
linked
poorer
outcomes
EC
patients
(p
<
.05).
Frequent
mutations
were
observed
genes,
suggesting
their
critical
role
disease
mechanisms.
highlights
links
among
EC,
ENDO,
OBY,
emphasizing
high
a
prognostic
marker
recurrent
alterations
promising
These
findings
provide
insights
into
underpinnings
of
present
new
avenues
for
targeted
therapies.
Язык: Английский
Can interventions targeting MDSCs improve the outcome of vaccination in vulnerable populations?
International Reviews of Immunology,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Дек. 21, 2024
Preventive
vaccination
is
a
crucial
strategy
for
controlling
and
preventing
infectious
diseases,
offering
both
effectiveness
cost-efficiency.
However,
despite
the
widespread
success
of
programs,
there
are
still
certain
population
groups
who
struggle
to
mount
adequate
responses
immunization.
These
at-risk
include
but
not
restricted
elderly,
overweight
individuals,
individuals
with
chronic
infections
cancer
patients.
All
these
characterized
by
persistent
inflammation.
Recent
studies
have
demonstrated
that
one
key
players
in
immune
regulation
promotion
inflammation
myeloid-derived
suppressor
cells
(MDSCs).
possess
wide
range
immunosuppressive
mechanisms
able
dampen
antigen-specific
antigen-nonspecific
manner,
thus
contributing
establishment
maintenance
an
inflammatory
environment.
Given
their
pivotal
role
modulation,
growing
interest
understanding
how
MDSCs
may
influence
efficacy
vaccines,
particularly
vulnerable
populations.
In
this
narrative
review,
we
discuss
whether
regulate
vaccine-induced
immunity
suppression
can
potentially
enhance
vaccine
Язык: Английский
Identification of prognostic significant markers of early diagnosis of obesity and metabolic disorders
Problems of Balneology Physiotherapy and Exercise Therapy,
Год журнала:
2024,
Номер
101(6), С. 71 - 71
Опубликована: Янв. 31, 2024
Obesity,
being
a
global
epidemic
of
the
21st
century,
increases
likelihood
various
diseases
and
conditions
that
are
associated
with
increased
mortality.
Given
risks
obesity
throughout
life,
identifying
early
predictors
its
development
is
priority
task
prevention.
Assessment
prognostic
significance
laboratory
parameters,
functional
tests
instrumental
examination
data
for
diagnosis
metabolic
disorders.
The
studies
were
conducted
at
Scientific
Clinical
Center
1
B.V.
Petrovsky
Russian
Surgery
participation
77
patients
(43
men
34
women)
aged
33
to
65
years.
After
signing
voluntary
informed
consent
special
study
processing
their
personal
data,
all
underwent
comprehensive
clinical,
examination.
design
provided
three-time
an
interval
6
12
months.
To
search
disorders,
we
used
algorithm
constructing
mathematical
model
multiple
regression.
dynamics
body
mass
index
insulin
resistance
served
as
resulting
feature.
build
predictive
model,
matrix
independent
variables
was
formed,
including
parameters
characterizing
biochemical
status
patients,
severity
systemic
inflammation,
composition,
well
arterial
stiffness
vascular
condition
based
on
results
ultrasound
duplex
scanning
brachiocephalic
arteries.
choice
most
informative
set
act
provides
achieving
maximum
additive
effect
in
explaining
variance
construction
actual
regression
selection
factors
carried
out
using
method
sequential
hypothesis
testing.
As
result
applying
testing,
three
(predictors)
identified
predict
degree
BMI
increase
four
accuracy
developed
verified
final
stage
study,
showed
high
information
content.
Two
clusters
identified:
cluster
risk
includes
inflammatory
response
index,
triglyceride-glucose
blood
leptin
level.
biomarkers
disorders
consists
atherogenicity
coefficient,
malondialdehyde
level,
inflammation
roundness
index.
Язык: Английский