Potential similarities in gut microbiota composition between autism spectrum disorder and neurotypical siblings: Insights from a comprehensive meta-analysis
Hongli Xiao,
Han Zhu,
Tong-Ao Zeng
и другие.
Neuroscience,
Год журнала:
2025,
Номер
567, С. 172 - 181
Опубликована: Янв. 8, 2025
Язык: Английский
Autism Spectrum Disorder, Oral Implications, and Oral Microbiota
Emiliana D’Angelo,
Fausto Fiori,
Giuseppe Andrea Ferraro
и другие.
Children,
Год журнала:
2025,
Номер
12(3), С. 368 - 368
Опубликована: Март 15, 2025
Background/Objectives:
Autism
spectrum
disorder
(ASD)
is
a
complex
neurodevelopmental
characterized
by
difficulties
in
social
interaction,
communication,
and
repetitive
behaviors.
Recent
evidence
indicates
significant
relationship
between
ASD
imbalances
microbiota,
particularly
the
oral
gastrointestinal
areas.
This
review
examines
impact
of
self-injurious
behaviors
(SIB),
sensory
sensitivity,
dietary
choices
on
comorbidities
associated
with
ASD.
Methods:
An
extensive
literature
was
conducted
using
PubMed
Scopus.
The
focus
human
studies
full-text
availability,
utilizing
search
terms
related
to
ASD,
health,
disorders.
research
evaluated
for
methodological
quality
its
relevance
connections
Results:
Individuals
face
unique
health
challenges,
including
injuries
from
increased
which
complicate
hygiene
care.
Selective
eating
can
lead
nutritional
deficiencies
worsen
issues.
Dysbiosis
gut
marked
altered
levels
acetate,
propionate,
butyrate,
interferes
gut-brain
oral-brain
connections,
contributing
behavioral
neurological
symptoms.
Treatment
options
such
as
probiotics,
fecal
microbiota
transfer,
integration
therapies
potentially
alleviate
symptoms
improve
life.
Conclusions:
suggests
bidirectional
influence
through
neuroinflammatory
mechanisms
metabolic
disturbances.
Proactive
strategies
focusing
dental
may
help
reduce
enhance
overall
management
underscoring
need
further
into
microbiota–host
interactions
their
therapeutic
potential.
Язык: Английский
The Impact of Gut Microbiota on the Development of Anxiety Symptoms—A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 933 - 933
Опубликована: Март 7, 2025
The
gut
microbiota
plays
a
key
role
in
mental
health,
with
growing
evidence
linking
its
composition
to
anxiety
and
depressive
disorders.
Research
on
this
topic
has
expanded
significantly
recent
years.
This
review
explores
alterations
the
of
individuals
disorders
examines
potential
therapeutic
effects
probiotics.
Background/Objectives:
aims
analyze
evaluate
probiotics
mitigating
symptoms.
By
examining
research,
study
seeks
highlight
gut–brain
connection
implications
for
health
interventions.
Materials
Methods:
A
literature
search
was
conducted
PubMed,
Embase,
CINAHL,
Google
Scholar,
focusing
studies
investigating
relationship
between
disorders,
as
well
impact
symptom
severity.
Results:
reviewed
suggest
that
often
exhibit
alterations,
including
reduced
microbial
diversity
lower
abundance
short-chain
fatty
acid-producing
bacteria.
Additionally,
probiotics,
particularly
those
from
Lactobacillus
genus,
may
help
alleviate
symptoms
by
modulating
composition.
Conclusions:
Gut
dysbiosis
appears
be
closely
linked
probiotic
interventions
could
represent
promising
avenue.
However,
further
research
is
needed
clarify
underlying
mechanisms
optimize
treatment
strategies.
Язык: Английский
Small Intestinal Bacterial and Fungal Overgrowth: Health Implications and Management Perspectives
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1365 - 1365
Опубликована: Апрель 17, 2025
Background/Objectives:
Small
Intestinal
Bacterial
Overgrowth
(SIBO)
and
Fungal
(SIFO)
are
distinct
yet
often
overlapping
conditions
characterized
by
an
abnormal
increase
in
microbial
populations
within
the
small
intestine.
SIBO
results
from
overgrowth
of
colonic
bacteria,
while
SIFO
is
driven
fungal
overgrowth,
primarily
involving
Candida
species.
Both
present
with
nonspecific
gastrointestinal
(GI)
symptoms
such
as
bloating,
abdominal
pain,
diarrhea,
malabsorption,
making
differentiation
between
challenging.
This
review
aims
to
elucidate
underlying
mechanisms,
risk
factors,
diagnostic
challenges,
management
strategies
associated
SIFO.
Methods:
A
comprehensive
current
literature
was
conducted,
focusing
on
pathophysiology,
modalities,
therapeutic
approaches
for
Results:
commonly
factors
reduced
gastric
acid
secretion,
impaired
gut
motility,
structural
abnormalities
like
bowel
obstruction
diverticula.
It
frequently
diagnosed
using
jejunal
aspirates
(≥105
colony
forming
units
(CFUs)/mL)
or
breath
tests.
In
contrast,
linked
prolonged
antibiotic
use,
immunosuppression,
microbiome
dysbiosis,
diagnosis
relying
cultures
intestinal
due
absence
standardized
protocols.
Conclusion:
The
clinical
overlap
frequent
misdiagnosis
highlight
need
improved
tools
a
multidisciplinary
approach
management.
emphasizes
importance
understanding
mechanisms
behind
SIFO,
how
they
relate
other
health
outcomes,
potential
optimize
patient
care
outcomes.
Язык: Английский
IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis
Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Май 16, 2025
Autism
spectrum
disorder
(ASD)
is
a
developmental
that
characterized
by
deficits
in
social
communication
and
restricted,
repetitive,
stereotyped
behaviors.
In
addition
to
neurobehavioral
symptoms,
children
with
ASD
often
have
gastrointestinal
symptoms
(e.g.
constipation,
diarrhea,
gas,
abdominal
pain,
reflux).
Several
studies
proposed
the
role
of
gut
microbiota
metabolic
disorders
neurodevelopmental
dysfunction
patients;
these
results
offer
promising
avenues
for
novel
treatments
this
disorder.
Interventions
targeting
-
such
as
fecal
transplant
(FMT),
therapy
(MTT),
probiotics,
prebiotics,
synbiotics,
antibiotics,
antifungals,
diet
promise
improve
health
can
potentially
neurological
symptoms.
The
modulation
using
MTT
has
shown
beneficial
long-term
effects
on
GI
core
autism.
Also,
resemble
typically
developing
individuals
seems
be
most
intervention.
As
carried
out
are
open-label
studies,
more
extensive
double-blinded
randomized
control
trials
needed
confirm
efficacy
therapeutic
option
ASD.
This
review
examines
current
clinical
research
evidence
use
interventions
target
microbiome
probiotics/prebiotics,
their
effectiveness
changing
improving
Язык: Английский
Association between Purpureocillium, amino acid metabolism and cognitive function in drug-naïve, first-episode schizophrenia
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Май 22, 2025
Cognitive
impairments
in
patients
with
schizophrenia
(SCZ)
is
associated
poor
social
functioning
and
long-term
prognosis.
Our
previous
work
suggests
that
some
key
fungal
markers
including
Purpureocillium,
are
linked
to
SCZ.
We
present
a
case-control
study
includes
136
first-episode,
drug-naïve
SCZ
92
healthy
controls
(HCs).
Untargeted
liquid
chromatography/mass
spectrometry
(LC/MS)
was
utilized
measure
serum
metabolite
levels.
The
abundance
of
Purpureocillium
assessed
using
the
internal
transcribed
spacer
(ITS)
analysis.
function
measured
MATRICS
Consensus
Battery.
demonstrated
significant
declines
attention
alertness
(AV),
speed
processing
(SOP)
individuals
found
have
negative
correlation
multiple
domains
cognitive
function.
Additionally,
SCZ-related
metabolic
2-Oxoarginine,
N-Acetyl-serotonin,
Ergothioneine,
Isobutyric
acid
Biotin
were
significantly
both
scores
(SOP
AV).
Mediation
analyses
revealed
had
direct
indirect
effects
on
SOP
AV)
through
(2-Oxoarginine,
Ergothioneine).
Further,
be
correlated
inflammation
oxidative
stress,
which
been
pathogenesis
findings
suggest
might
its
regulation
metabolism
specific
amino
acids
involved
stress.
A
better
understanding
about
fungal-immune-metabolites
association
may
lead
novel
treatment
approaches
improve
Язык: Английский