Association between Purpureocillium, amino acid metabolism and cognitive function in drug-naïve, first-episode schizophrenia DOI Creative Commons
Xiuxia Yuan, Xue Li, Lijuan Pang

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Май 22, 2025

Cognitive impairments in patients with schizophrenia (SCZ) is associated poor social functioning and long-term prognosis. Our previous work suggests that some key fungal markers including Purpureocillium, are linked to SCZ. We present a case-control study includes 136 first-episode, drug-naïve SCZ 92 healthy controls (HCs). Untargeted liquid chromatography/mass spectrometry (LC/MS) was utilized measure serum metabolite levels. The abundance of Purpureocillium assessed using the internal transcribed spacer (ITS) analysis. function measured MATRICS Consensus Battery. demonstrated significant declines attention alertness (AV), speed processing (SOP) individuals found have negative correlation multiple domains cognitive function. Additionally, SCZ-related metabolic 2-Oxoarginine, N-Acetyl-serotonin, Ergothioneine, Isobutyric acid Biotin were significantly both scores (SOP AV). Mediation analyses revealed had direct indirect effects on SOP AV) through (2-Oxoarginine, Ergothioneine). Further, be correlated inflammation oxidative stress, which been pathogenesis findings suggest might its regulation metabolism specific amino acids involved stress. A better understanding about fungal-immune-metabolites association may lead novel treatment approaches improve

Язык: Английский

Potential similarities in gut microbiota composition between autism spectrum disorder and neurotypical siblings: Insights from a comprehensive meta-analysis DOI

Hongli Xiao,

Han Zhu,

Tong-Ao Zeng

и другие.

Neuroscience, Год журнала: 2025, Номер 567, С. 172 - 181

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1

Autism Spectrum Disorder, Oral Implications, and Oral Microbiota DOI Creative Commons

Emiliana D’Angelo,

Fausto Fiori,

Giuseppe Andrea Ferraro

и другие.

Children, Год журнала: 2025, Номер 12(3), С. 368 - 368

Опубликована: Март 15, 2025

Background/Objectives: Autism spectrum disorder (ASD) is a complex neurodevelopmental characterized by difficulties in social interaction, communication, and repetitive behaviors. Recent evidence indicates significant relationship between ASD imbalances microbiota, particularly the oral gastrointestinal areas. This review examines impact of self-injurious behaviors (SIB), sensory sensitivity, dietary choices on comorbidities associated with ASD. Methods: An extensive literature was conducted using PubMed Scopus. The focus human studies full-text availability, utilizing search terms related to ASD, health, disorders. research evaluated for methodological quality its relevance connections Results: Individuals face unique health challenges, including injuries from increased which complicate hygiene care. Selective eating can lead nutritional deficiencies worsen issues. Dysbiosis gut marked altered levels acetate, propionate, butyrate, interferes gut-brain oral-brain connections, contributing behavioral neurological symptoms. Treatment options such as probiotics, fecal microbiota transfer, integration therapies potentially alleviate symptoms improve life. Conclusions: suggests bidirectional influence through neuroinflammatory mechanisms metabolic disturbances. Proactive strategies focusing dental may help reduce enhance overall management underscoring need further into microbiota–host interactions their therapeutic potential.

Язык: Английский

Процитировано

1

The Impact of Gut Microbiota on the Development of Anxiety Symptoms—A Narrative Review DOI Open Access

Kamil Nikel,

Michał Stojko,

Joanna Smolarczyk

и другие.

Nutrients, Год журнала: 2025, Номер 17(6), С. 933 - 933

Опубликована: Март 7, 2025

The gut microbiota plays a key role in mental health, with growing evidence linking its composition to anxiety and depressive disorders. Research on this topic has expanded significantly recent years. This review explores alterations the of individuals disorders examines potential therapeutic effects probiotics. Background/Objectives: aims analyze evaluate probiotics mitigating symptoms. By examining research, study seeks highlight gut–brain connection implications for health interventions. Materials Methods: A literature search was conducted PubMed, Embase, CINAHL, Google Scholar, focusing studies investigating relationship between disorders, as well impact symptom severity. Results: reviewed suggest that often exhibit alterations, including reduced microbial diversity lower abundance short-chain fatty acid-producing bacteria. Additionally, probiotics, particularly those from Lactobacillus genus, may help alleviate symptoms by modulating composition. Conclusions: Gut dysbiosis appears be closely linked probiotic interventions could represent promising avenue. However, further research is needed clarify underlying mechanisms optimize treatment strategies.

Язык: Английский

Процитировано

0

Small Intestinal Bacterial and Fungal Overgrowth: Health Implications and Management Perspectives DOI Open Access
Noha Salah Soliman, Caroline Kruithoff, Erin Marie D. San Valentin

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1365 - 1365

Опубликована: Апрель 17, 2025

Background/Objectives: Small Intestinal Bacterial Overgrowth (SIBO) and Fungal (SIFO) are distinct yet often overlapping conditions characterized by an abnormal increase in microbial populations within the small intestine. SIBO results from overgrowth of colonic bacteria, while SIFO is driven fungal overgrowth, primarily involving Candida species. Both present with nonspecific gastrointestinal (GI) symptoms such as bloating, abdominal pain, diarrhea, malabsorption, making differentiation between challenging. This review aims to elucidate underlying mechanisms, risk factors, diagnostic challenges, management strategies associated SIFO. Methods: A comprehensive current literature was conducted, focusing on pathophysiology, modalities, therapeutic approaches for Results: commonly factors reduced gastric acid secretion, impaired gut motility, structural abnormalities like bowel obstruction diverticula. It frequently diagnosed using jejunal aspirates (≥105 colony forming units (CFUs)/mL) or breath tests. In contrast, linked prolonged antibiotic use, immunosuppression, microbiome dysbiosis, diagnosis relying cultures intestinal due absence standardized protocols. Conclusion: The clinical overlap frequent misdiagnosis highlight need improved tools a multidisciplinary approach management. emphasizes importance understanding mechanisms behind SIFO, how they relate other health outcomes, potential optimize patient care outcomes.

Язык: Английский

Процитировано

0

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis DOI
Seung Hyeon Kim,

Zachary White,

Anastasiia Gainullina

и другие.

Immunity, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder DOI Creative Commons

Evelyn Takyi,

Khemlal Nirmalkar, James B. Adams

и другие.

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Май 16, 2025

Autism spectrum disorder (ASD) is a developmental that characterized by deficits in social communication and restricted, repetitive, stereotyped behaviors. In addition to neurobehavioral symptoms, children with ASD often have gastrointestinal symptoms (e.g. constipation, diarrhea, gas, abdominal pain, reflux). Several studies proposed the role of gut microbiota metabolic disorders neurodevelopmental dysfunction patients; these results offer promising avenues for novel treatments this disorder. Interventions targeting - such as fecal transplant (FMT), therapy (MTT), probiotics, prebiotics, synbiotics, antibiotics, antifungals, diet promise improve health can potentially neurological symptoms. The modulation using MTT has shown beneficial long-term effects on GI core autism. Also, resemble typically developing individuals seems be most intervention. As carried out are open-label studies, more extensive double-blinded randomized control trials needed confirm efficacy therapeutic option ASD. This review examines current clinical research evidence use interventions target microbiome probiotics/prebiotics, their effectiveness changing improving

Язык: Английский

Процитировано

0

Association between Purpureocillium, amino acid metabolism and cognitive function in drug-naïve, first-episode schizophrenia DOI Creative Commons
Xiuxia Yuan, Xue Li, Lijuan Pang

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Май 22, 2025

Cognitive impairments in patients with schizophrenia (SCZ) is associated poor social functioning and long-term prognosis. Our previous work suggests that some key fungal markers including Purpureocillium, are linked to SCZ. We present a case-control study includes 136 first-episode, drug-naïve SCZ 92 healthy controls (HCs). Untargeted liquid chromatography/mass spectrometry (LC/MS) was utilized measure serum metabolite levels. The abundance of Purpureocillium assessed using the internal transcribed spacer (ITS) analysis. function measured MATRICS Consensus Battery. demonstrated significant declines attention alertness (AV), speed processing (SOP) individuals found have negative correlation multiple domains cognitive function. Additionally, SCZ-related metabolic 2-Oxoarginine, N-Acetyl-serotonin, Ergothioneine, Isobutyric acid Biotin were significantly both scores (SOP AV). Mediation analyses revealed had direct indirect effects on SOP AV) through (2-Oxoarginine, Ergothioneine). Further, be correlated inflammation oxidative stress, which been pathogenesis findings suggest might its regulation metabolism specific amino acids involved stress. A better understanding about fungal-immune-metabolites association may lead novel treatment approaches improve

Язык: Английский

Процитировано

0