Intermittent fasting applied in combination with astaxanthin alleviates D‐galactose‐induced aging in rats: Comparison in oxidative stress, immune response, and metabolomics
Journal of Food Science,
Год журнала:
2025,
Номер
90(4)
Опубликована: Апрель 1, 2025
Effective
anti-aging
strategies
involving
dietary
restriction
and
antioxidant
supplementation
are
gaining
increasing
research
attention,
while
the
health
effects
of
their
combined
intervention
rarely
reported.
In
this
study,
for
first
time,
we
investigated
underlying
mechanisms
intermittent
fasting
(IF),
astaxanthin
(AX),
combination
in
D-galactose-induced
aging
rats.
Our
results
demonstrated
that
these
three
treatments
effectively
inhibited
malondialdehyde
levels
improved
activity
endogenous
enzymes
brain,
liver,
serum
Simultaneously,
IF
AX
had
a
synergistic
effect
on
recovery
brain
mitochondrial
injury
as
evidenced
by
permeability
transition
pore
openness,
membrane
potential,
respiratory
chain
complex
enzyme
activity,
cortical
hippocampal
lesions.
Notably,
significantly
increased
Immunoglobulin
M
(55.66
±
3.23%),
immunoglobulin
G
(34.41
2.65%),
IL-2
(23.49
1.78%)
compared
with
model
group.
Moreover,
reduced
accumulation
pro-inflammatory
factor
IL-6
(23.06
2.02%),
induced
more
remarkable
reduction
IL-1β
(35.92
3.06%)
serum.
Considering
metabolomics
analysis,
hypothesized
played
positive
role
regulation
nervous
system,
which
was
associated
differential
metabolites
lysope
16:0,
N-Acety-L-tyrosine,
L-Alanyl-L-Lysine.
This
reveals
therapy
provided
efficacy
enhancing
resistance
to
oxidative
stress,
ameliorating
dysfunction,
restoring
immune
system.
These
findings
might
have
significant
implications
further
studies
exploration
effective
therapy.
Язык: Английский
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Aging and Disease,
Год журнала:
2013,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2013
Aging
is
characterized
by
progressive
multisystem
deterioration
driven
molecular
and
cellular
mechanisms
encapsulated
in
the
twelve
hallmarks
of
aging.
Green
tea
(GT),
derived
from
Camellia
sinensis,
has
garnered
significant
scientific
interest
due
to
its
rich
polyphenolic
composition,
particularly
epigallocatechin-3-gallate,
pleiotropic
health
benefits.
In
this
narrative
review,
we
explored
multifaceted
through
which
GT
may
mitigate
aging
hallmarks.
Evidence
vitro,
animal,
human
studies
shown
that
polyphenols
can
enhance
DNA
repair
pathways,
preserve
telomere
length,
modulate
epigenetic
markers,
improve
proteostasis
autophagic
flux,
regulate
nutrient-sensing
networks,
rejuvenate
mitochondrial
function.
Additionally,
exhibits
anti-inflammatory
properties
restore
a
physiological
gut
microbiota
composition.
Beyond
effects,
consumption
humans
been
associated
with
improved
cognitive
function,
cardiovascular
health,
muscle
preservation,
metabolic
regulation
populations.
Collectively,
these
findings
highlight
GT's
potential
as
naturally
occurring
geroscience
intervention
capable
addressing
interconnected
network
processes
more
comprehensively
than
single-target
pharmaceuticals.
Future
research
should
focus
on
optimizing
dosing
regimens,
exploring
synergies
other
anti-aging
strategies,
investigating
personalized
responses
interventions.
Язык: Английский