Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management
Frontiers in Sports and Active Living,
Год журнала:
2025,
Номер
7
Опубликована: Март 6, 2025
Background
Tryptophan
(TRP)
metabolism
through
the
kynurenine
(KYN)
pathway
is
influenced
by
inflammatory
mediators,
generating
metabolites
that
regulate
immune
and
responses.
Exercise
has
been
proposed
as
a
modulator
of
this
pathway,
but
its
role
in
health
benefits
chronic
disease
management
remains
unclear.
Objective
This
systematic
review
examines
exercise-induced
adaptations
KYN
their
potential
implications
for
management.
Additionally,
we
identify
key
methodological
considerations
future
research.
Methods
A
structured
search
PubMed/Medline,
Web
Science,
Scopus
was
conducted
up
to
October
2024
clinical
trials
investigating
effects
exercise
training
on
pathway.
Results
Of
2,795
articles
initially
found,
13
involving
592
participants
met
inclusion
criteria.
Most
studies
reported
particularly
cancer
survivors.
These
appeared
be
intensity
duration.
However,
several
limitations
were
noted,
no
included
patients
with
metabolic
or
cardiovascular
diseases.
Conclusions
Here,
show
modulates
both
healthy
diseased
populations,
highlighting
prevention
further
randomized-controlled
are
needed
clarify
mechanisms
applications,
Systematic
Review
Registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481
,
PROSPERO
(CRD42022351481).
Язык: Английский
Exploring the Mechanism of Action of Honeybran‐Fried Cimicifuga Rhizoma in the Treatment of IBS‐D Based on Metabolomics and Network Pharmacology
Biomedical Chromatography,
Год журнала:
2025,
Номер
39(5)
Опубликована: Март 24, 2025
ABSTRACT
Honeybran‐fried
Cimicifuga
Rhizoma
(HBCR)
is
often
used
to
treat
prolonged
diarrhea
and
prolapse
of
the
anus,
uterine
prolapse,
gastric
ptosis
caused
by
spleen
qi
deficiency
inability
elevate
qi,
thus
lowering
middle
qi.
Rats
were
divided
randomly
into
four
groups.
Fecal
samples
rats
in
each
group
subjected
metabolomics
analysis.
We
identified
chemical
components
HBCR
using
liquid
chromatography–tandem
mass
spectrometry.
predicted
potential
active
key
targets
network
pharmacology
construct
a
“drug–potential
ingredient–target–disease”
network.
The
screened
differential
metabolites
analysis
combined
pathway
Pharmacodynamic
indices
showed
that
had
good
therapeutic
effect
upon
IBS‐D.
Metabolomics
revealed
26
treatment
IBS‐D
HBCR.
A
total
69
identified,
32
296
screened.
Combination
for
joint
may
be
affected
metabolism
linoleic
acid,
retinol,
arachidonic
tryptophan.
significant
effects
with
Язык: Английский
Peripheral Kynurenine Pathway Metabolites in Patients with Psoriasis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3139 - 3139
Опубликована: Март 28, 2025
Psoriasis
is
a
systemic
disease
affecting
2-3%
of
the
general
population.
Tryptophan
(TRP)
an
amino
acid
metabolized
in
kynurenine
pathway
(KP).
The
aim
this
study
was
to
assess
pathway's
metabolites
serum
and
urine
psoriatic
patients
explore
possible
interplay
with
disease's
pathogenesis
its
comorbidities.
involved
60
plaque
psoriasis
30
healthy
volunteers
matched
for
gender,
age,
BMI.
Serum
samples
were
taken
from
participants
tested
TRP,
indoleamine
2,3-dioxygenase
(IDO),
2,3-tryptophan
dioxygenase
(TDO),
(KYN),
kynurenic
(KYNA),
quinolinic
(QUIN),
numerous
laboratory
parameters.
Correlations
between
metabolites'
levels
clinical,
parameters
depression
occurrence
statistically
evaluated.
Concentrations
tryptophan,
acid,
significantly
higher
among
(p
<
0.05
p
0.001,
0.001
respectively).
A
significant
stimulation
suggests
role
chronic
inflammation
or
Further
research
needed
discover
whether
increase
KP
indicator
compensatory
mechanism
psoriasis.
Язык: Английский
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Neurotoxicity Research,
Год журнала:
2025,
Номер
43(2)
Опубликована: Март 28, 2025
Язык: Английский
Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 372 - 372
Опубликована: Дек. 9, 2024
CY1-4,
9-nitropyridine
[2',3':4,5]
pyrimido
[1,2-α]
indole
-5,11-
dione,
is
an
indoleamine
2,3-dioxygenase
(IDO)
inhibitor
and
a
poorly
water-soluble
substance.
It
very
important
to
increase
the
solubility
of
CY1-4
improve
its
bioavailability
therapeutic
effect.
In
this
study,
mesoporous
silica
nano-skeleton
carrier
material
Sylysia
was
selected
as
load
then
drug
delivery
system
(MSNM@CY1-4)
prepared
by
coating
hydrophilic
polymer
Hydroxypropyl
methylcellulose
(HPMC)
lipid
Distearoylphosphatidyl-ethanolamine-poly(ethylene
glycol)
Язык: Английский