Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)
Molecular Medicine Reports,
Год журнала:
2025,
Номер
31(4), С. 1 - 34
Опубликована: Фев. 24, 2025
Flavonoids
are
a
group
of
polyphenolic
compounds
distributed
in
vegetables,
fruits
and
other
plants,
which
have
considerable
antioxidant,
anti‑tumor
anti‑inflammatory
activities.
Several
types
gastrointestinal
(GI)
cancer
the
most
common
malignant
tumors
world.
A
large
number
studies
shown
that
flavonoids
inhibitory
effects
on
cancer,
they
recognized
as
class
potential
drugs.
Therefore,
present
review
investigated
molecular
mechanisms
treatment
different
GI
summarized
drug
delivery
systems
commonly
used
to
improve
their
bioavailability.
First,
classification
therapeutic
various
human
diseases
were
briefly
introduced.
Then,
clarify
mechanism
action
body,
metabolic
process
body
associated
signaling
pathways
causing
five
discussed,
well
corresponding
targets
flavonoids.
Finally,
clinical
settings,
poor
water
solubility,
low
permeability
inferior
stability,
lead
absorption
efficiency
vivo.
three
widely
summarized.
Suggestions
for
improving
bioavailability
focus
next
stage
research
also
put
forward.
Язык: Английский
Investigating small molecules in Propolis as Nipah virus glycoprotein (NiV-G) inhibitors through molecular interaction studies
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42595 - e42595
Опубликована: Фев. 1, 2025
Despite
the
significant
fatality
rates
associated
with
Nipah
virus
(NiV)
outbreaks
in
South
Asia,
including
Bangladesh,
and
India,
till
today,
there
is
no
approved
medications
to
treat
it.
In
this
context,
small
molecules
propolis
were
computationally
screened
through
pharmacokinetic
toxicity
studies
followed
by
molecular
docking
dynamics
simulation
glycoprotein
(NiV-G
protein)
assess
their
anti-Nipah
potential.
A
thorough
literature
analysis
was
performed
identify
antiviral
compounds
from
a
pool
of
84
experimental
articles.
Following
ADMET
analysis,
27
out
34
docked
against
NiV-G
compared
control
ligand,
ribavirin,
which
an
investigational
drug
Nipah.
The
revealed
that
bauer-7-en-3β-yl
acetate
(BA)
moronic
acid
(MA)
bound
more
strongly
active
site
than
ribavirin
other
ligands.
Investigation
root-mean-square
deviation
(RMSD),
root
mean
square
fluctuations
(RMSF),
radius
gyration
(Rg),
solvent
accessible
surface
area
(SASA),
(MolSA),
binding
free
energy
(MM-PBSA),
complexity
hydrogen
bonds
(HBs),
secondary
structure
ligand-target
interactions
for
100
ns
(MD)
study
further
supported
complex's
stability
compactness.
Therefore,
silico
interaction
reports
both
may
be
possible
candidates
infection.
Язык: Английский
Enhancing Curcumol Delivery through PD-1 Targeted Nanocarriers: A Novel Therapeutic Approach for Prostate Cancer
Phytomedicine,
Год журнала:
2025,
Номер
141, С. 156595 - 156595
Опубликована: Март 2, 2025
Язык: Английский
Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
Toxics,
Год журнала:
2025,
Номер
13(3), С. 194 - 194
Опубликована: Март 8, 2025
Propolis
has
been
well
known
for
centuries
as
a
natural
preventive
and
therapeutic
agent.
Its
numerous
health
benefits
are
mainly
attributed
to
its
high
content
of
phenolic
compounds
that
have
remarkable
antioxidant
activity.
Since
phenolics
may
exert
dual
nature
(pro-oxidant
antioxidant)
the
aim
this
study
was
investigate
safety
profile
ethanolic
extract
propolis
related
flavonoid
galangin
their
ability
protect
lymphocytes
from
irinotecan-induced
cyto/genotoxicity
in
vitro.
Isolated
human
peripheral
blood
were
exposed
3
h
three
concentrations
corresponding
average
daily
dose
0.25
mL
[propolis
70%
ethanol
(3:7,
w/w)],
five-
ten-fold
higher
concentration.
Cyto-
genoprotective
effects
tested
using
cytokinesis-block
micronucleus
cytome
assay.
Treatment
with
selected
exerted
biocompatibility
diminished
level
cytogenetic
damage
caused
by
irinotecan.
at
same
concentration
offered
stronger
protective
effect
than
single
galangin.
Also,
apoptosis
prevailing
mechanism
cell
death
our
experimental
conditions.
These
preliminary
results
speak
favour
future
investigations
other
available
methods
models.
Язык: Английский
Network Pharmacology and Experimental Validation Reveal Therapeutic Potential of Propolis in UV-Induced Allergic Dermatitis
Foods,
Год журнала:
2025,
Номер
14(6), С. 996 - 996
Опубликована: Март 14, 2025
Propolis
demonstrates
diverse
pharmacological
properties
encompassing
antimicrobial,
anti-inflammatory,
antioxidant,
immunomodulatory,
and
wound-healing
activities.
This
study
investigated
the
therapeutic
mechanism
of
propolis
against
ultraviolet
(UV)-induced
allergic
dermatitis
through
an
integrated
approach
combining
network
pharmacology
with
in
vitro
experimental
validation.
The
targets
components
were
conducted
PubChem,
EMBL-EBI,
SEA
Search
Server
databases,
disease-associated
for
atopic
related
conditions
extracted
from
GeneCards.
overlapping
between
UV-induced
screened.
Gene
Ontology
(GO)
Enrichment
analysis
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
performed.
key
further
validated
ELISA
experiments
using
HSF
cells.
results
show
that
there
28
dermatitis.
GO
1246
terms
biological
functions,
52
cellular
components,
98
molecular
functions.
KEGG
obtained
110
signaling
pathways.
protein-protein
interaction
(PPI)
showed
TNF,
NFKB1,
MMP-9,
IL-2
hub
proteins.
experiment
confirmed
reduced
levels
MMP-9
UBV-induced
cells
a
dose-dependent
manner.
These
findings
provide
mechanistic
evidence
supporting
as
promising
functional
food,
dietary
supplements,
or
medicinal
agent
skin
disorders.
Язык: Английский
Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients
The EPMA Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Cancer
drug
resistance
poses
a
significant
challenge
in
oncology,
primarily
driven
by
cancer
cell
plasticity,
which
promotes
tumor
initiation,
progression,
metastasis,
and
therapeutic
evasion
many
different
cancers.
Breast
cancers
(BCs)
are
prominent
example
of
that,
with
an
estimated
2.3
million
new
cases
670,000
BC-related
deaths
registered
worldwide
annually.
Triple-negative
BC
is
especially
challenging
for
treatments
demonstrating
particularly
aggressive
disease
course,
early
manifestation
metastatic
disease,
frequent
drug-resistant
types,
poor
individual
outcomes.
Although
chemosensitizing
agents
have
been
developed,
their
clinical
utility
oncology
remains
unproven.
The
mitogen-activated
protein
kinase
(MAPK)
pathway
considered
critical
regulator
intracellular
extracellular
signaling
highly
relevant
both
—
genetic
epigenetic
modifications.
Dysregulation
the
MAPK
pathways
plays
role
conferring
chemoresistance
BC.
Contextually,
targeting
represents
promising
strategy
overcoming
enhancing
efficacy
anticancer
treatment.
On
other
hand,
flavonoids,
class
phytochemicals,
key
modulators
signaling.
Flavonoids
interact
ERK,
JNK,
p38,
ERK5
cascade
present
avenue
developing
novel
anti-cancer
therapies
re-sensitizing
treatment
Compounds
such
as
quercetin,
kaempferol,
genistein,
luteolin,
myricetin,
EGCG,
baicalein,
baicalin,
nobiletin,
morin,
delphinidin,
acacetin,
isorhamnetin,
apigenin,
silymarin,
among
others,
identified
specific
signaling,
exerting
complex
downstream
effects
cells
increasing
therewith
suppressing
growth
aggressivity.
These
properties
reflect
mechanisms
great
relevance
to
overcome
overall
management.
This
article
highlights
corresponding
provides
clinically
illustrations
framework
3P
medicine
primary
(protection
individuals
at
high
risk
against
health-to-disease
transition)
secondary
care
progression).
3PM
novelty
makes
good
use
patient
phenotyping
stratification,
predictive
multi-level
diagnostics,
application
Artificial
Intelligence
(AI)
tools
individualized
interpretation
big
data
all
proposed
cost-effective
tailored
profiles
clear
benefits
patients
advanced
Язык: Английский
In Vitro Inhibition of Colon Cancer Stem Cells by Natural Polysaccharides Obtained from Wheat Cell Culture
Polymers,
Год журнала:
2025,
Номер
17(8), С. 1048 - 1048
Опубликована: Апрель 12, 2025
Natural
polysaccharides
(PSs)
have
shown
inhibitory
effects
on
differentiated
cancer
cells
(DCCs),
but
their
activity
against
stem
(CSCs)
remains
poorly
understood.
Here,
we
report
that
PSs
from
wheat
cell
cultures
(WCCPSs)
inhibit
the
proliferation
of
both
DCCs
and
CSCs
derived
HCT-116
colorectal
cells.
Among
them,
NA
DC
fractions
showed
strongest
anti-CSC
activity.
NA,
rich
in
xylose,
was
effective
at
lower
concentrations,
while
DC,
enriched
xylose
galacturonic
acid
(GalUA),
exhibited
higher
potency,
with
a
IC50
preferential
doses.
WCCPSs
reduced
β-catenin
levels,
some
also
downregulated
Ep-CAM,
CD44,
c-Myc.
Notably,
increased
caspase-3
without
inducing
cytochrome
C
caspase-8
overexpression,
suggesting
mechanism
promoting
CSC
differentiation
rather
than
apoptosis.
Correlation
analysis
linked
content
to
c-Myc
expression,
GalUA
levels
caspase-3.
These
results
suggest
WCCPS
bioactivity
may
be
related
monosaccharide
composition.
Overall,
our
findings
support
potential
wheat-derived
as
CSC-targeting
agents
suppress
self-renewal
promote
differentiation,
offering
promising
approach
reduce
tumor
aggressiveness
recurrence.
Язык: Английский