International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1770 - 1770
Опубликована: Фев. 19, 2025
Endometriosis is a complicated, estrogen-dependent gynecological condition with high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women's physical and mental health exacerbates socioeconomic burden. However, specific mechanisms behind occurrence endometriosis-related pain remain unclear. It currently believed that endometriosis related to various factors, such immune abnormalities, endocrine disorders, brain-gut axis, angiogenesis, mechanical stimulation. These factors induce systemic chronic inflammation, which stimulates nerves subsequently alters neural plasticity, leading nociceptive sensitization thereby causing pain. In this paper, we compile review articles published on study mechanisms. Starting from influencing associated explain relationship between these inflammation further elaborate potential by induces sensitization. We aim reveal possible pain, well sensitization, offer new targets for treatment
Язык: Английский