Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases DOI Open Access
Donia Jerab,

Ferdinand Blangero,

Paulo César Trindade da Costa

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1253 - 1253

Опубликована: Апрель 3, 2025

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are known to help resolve inflammation through generation of anti-inflammatory eicosanoids and specialized pro-resolving mediators, including resolvins, protectins, maresins. Through binding the GPR120/FFAR4 receptor, their beneficial effects result from phospholipid membrane remodeling, impairment inflammatory signaling molecules clustering, subsequent inhibition NF-κB inflammasome activation, a reduction in oxidative stress. Obesity, chronic disease that contributes metabolic disorders, is alleviated by n-3 PUFAs. In adipose tissue (AT) individuals with obesity, PUFAs counteract hypoxia, inhibit immune cell infiltration AT inflammation, improve insulin sensitivity, reduce fat mass. Beyond AT, also alleviate other disorders such as metabolic-associated steatotic liver (MASLD), gut dysbiosis, and/or renal dysfunction. cardiovascular (CVD), they mainly recommended secondary prevention for patients coronary heart risks. This review provides an in-depth analysis benefits obesity related diseases, examining both mechanistic clinical aspects. Additionally, it explores obesity-related conditions, bowel disease, psoriasis, rheumatoid arthritis, osteoarthritis, multiple sclerosis, targeting specific pathophysiological mechanisms. Clinical applications limitations discussed based on findings human trials.

Язык: Английский

Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases DOI Open Access
Donia Jerab,

Ferdinand Blangero,

Paulo César Trindade da Costa

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1253 - 1253

Опубликована: Апрель 3, 2025

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are known to help resolve inflammation through generation of anti-inflammatory eicosanoids and specialized pro-resolving mediators, including resolvins, protectins, maresins. Through binding the GPR120/FFAR4 receptor, their beneficial effects result from phospholipid membrane remodeling, impairment inflammatory signaling molecules clustering, subsequent inhibition NF-κB inflammasome activation, a reduction in oxidative stress. Obesity, chronic disease that contributes metabolic disorders, is alleviated by n-3 PUFAs. In adipose tissue (AT) individuals with obesity, PUFAs counteract hypoxia, inhibit immune cell infiltration AT inflammation, improve insulin sensitivity, reduce fat mass. Beyond AT, also alleviate other disorders such as metabolic-associated steatotic liver (MASLD), gut dysbiosis, and/or renal dysfunction. cardiovascular (CVD), they mainly recommended secondary prevention for patients coronary heart risks. This review provides an in-depth analysis benefits obesity related diseases, examining both mechanistic clinical aspects. Additionally, it explores obesity-related conditions, bowel disease, psoriasis, rheumatoid arthritis, osteoarthritis, multiple sclerosis, targeting specific pathophysiological mechanisms. Clinical applications limitations discussed based on findings human trials.

Язык: Английский

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