National analysis of the dietary index for gut microbiota and kidney stones: evidence from NHANES (2007–2018)

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 13, 2025

Background Previous studies have highlighted the effects of diet and gut microbiota on incidence kidney stones, dietary index for (DI-GM) is a new that accurately represents variety microbiota. The current study intends to examine potential correlation between DI-GM stones. Methods Data from 2007–2018 National Health Nutrition Examination Survey (NHANES) were employed in this cross-sectional study. history stones was assessed using conditions questionnaire. In order multivariate logistic regression implemented. Additionally, smoothed curve fitting, subgroup analyses, sensitivity analyses conducted. Results investigation encompassed total 21,587 participants. After adjusting all covariates, we found negatively related (OR = 0.96, 95% CI 0.93–0.98, p 0.0021). Compared those lowest quartile, participants highest quartile had lower prevalence 0.86, 0.75–0.98, 0.0252). fitting revealed linearly associated with results proved robustness main analyses. Conclusion A negative supported by evidence presented This finding emphasizes benefits structure according reducing Further research should validate discovery employing longitudinal studies.

Язык: Английский

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Linear association of the dietary index for gut microbiota with insulin resistance and type 2 diabetes mellitus in U.S. adults: the mediating role of body mass index and inflammatory markers

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 21, 2025

Background Gut microbiota is reported to be related the onset of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). The dietary index for gut (DI-GM) a novel reflecting diversity. We aimed evaluate association DI-GM with T2DM IR. Methods This cross-sectional research comprised 10,600 participants aged ≥20 from National Health Nutrition Examination Survey (NHANES) 2007–2018. employed weighted multivariable linear logistic regression models examine correlation Linear or nonlinear relationships were examined by restricted cubic spline (RCS) regression. Additionally, subgroup sensitivity analyses performed ensure reliability results. Mediation analysis explored roles body mass (BMI) inflammatory factors in these associations. Results Higher inversely associated (OR = 0.93, 95%CI: 0.89–0.98) IR 0.95, 0.91–0.99) after adjusting confounders. ≥ 6 group showed significantly lower risks 0.74, 0.60–0.91) 0.77, 0.62–0.95). RCS demonstrated relationship between T2DM, as well was also correlated risk markers T2DM. that BMI systemic inflammation response partly mediated IR, while immune-inflammation only Conclusion mediating this association.

Язык: Английский

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Dietary index for gut microbiota and its inverse association with female infertility: evidence from NHANES 2013–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 4, 2025

Background Infertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays crucial role in female reproductive health. This study aimed investigate association between Dietary Index for Gut Microbiota (DI-GM) and infertility. Methods We analyzed data from 8,910 participants aged 20–45 years NHANES 2013–2018 cycles. DI-GM scores were calculated based on dietary recall interviews, including 14 foods nutrients associated with Female infertility was identified through questionnaires. Weighted logistic regression models used assess relationship infertility, adjustments demographic, lifestyle, health-related covariates. Restricted cubic spline (RCS) analyses explored non-linear associations, subgroup ensured robustness of results. Results A significant negative observed (adjusted OR = 0.89, 95% CI: 0.83–0.95, p < 0.001). Participants ≥6 had 40% lower risk compared those 0–3 (OR 0.60, 0.44–0.82, RCS revealed an L-shaped relationship, threshold at 5. Subgroup indicated stronger associations women education levels coronary heart disease ( P interaction <0.05). Conclusion Our findings demonstrate higher score is reduced suggesting interventions targeting may offer cost-effective strategy improving Further longitudinal interventional are warranted confirm causality elucidate underlying mechanisms.

Язык: Английский

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A study of correlation of the dietary index for gut microbiota with non-alcoholic fatty liver disease based on 2007–2018 National Health and Nutrition Examination Survey

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 10, 2025

Objective To explore the correlation of dietary index for gut microbiota (DI-GM) with non-alcoholic fatty liver disease (NAFLD). Methods Data 6,711 participants were extracted from National Health and Nutrition Examination Survey (NHANES) during 2007–2018. A weighted logistic regression analysis was employed assessment DI-GM NAFLD, a restricted cubic spline (RCS) implemented to examine potential non-linear associations. Subgroup analyses conducted identify particularly susceptible groups. Additionally, synergistic effects different components on NAFLD risk assessed by quantile sum (WQS) regression. Results The exhibited statistically significant [OR (95%CI):0.91 (0.85, 0.98), p = 0.015]. results RCS indicated linear ( 0.810 non-linearity). Further stratified that negative consistent all subgroups. WQS revealed soybean (27%), refined grains (17%), coffee (16%), red meat (9%) had highest contribution weights NAFLD. Conclusion As an important tool influences diet microbiota, is negatively correlated factors. Soybean, grains, coffee, are key factors influencing direct shall be explored effectiveness prevention treatment evaluated improving scores via interventions.

Язык: Английский

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Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Background Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. Methods This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. Results In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65–0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles ( < 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). Conclusion The levels are inversely associated frailty, part association mediated parameters.

Язык: Английский

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