Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Cell Metabolism, Год журнала: 2019, Номер 29(3), С. 592 - 610

Опубликована: Март 1, 2019

Язык: Английский

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The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2018, Номер 17(5), С. 1054 - 1112

Опубликована: Июль 10, 2018

Abstract Flavonoids are plant‐derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and complex pathways involved bioavailability of flavonoids body now well understood. In recent years, been appreciated that gut microbiome plays major role flavonoid action, but much progress still needs to be made this area. Since first publications health effects flavonoids, their action is understood protect against various stresses, mechanism evolved from debunked simple direct antioxidant hypothesis into an understanding molecular targets enzymes specific cell types. This review traces development field over past 8 decades, indicates current state art, how was reached. Future recommendations based historical analysis (a) focus key areas (b) perform intervention studies focusing protective effects, (c) carry out cellular vitro experiments using appropriate cells together chemical form found at site action; could native compounds food for digestion intestine, conjugated metabolites blood after absorption small intestine cells, or forms tissues catabolism by microbiota.

Язык: Английский

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Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review

Obesity Reviews, Год журнала: 2016, Номер 17(7), С. 573 - 586

Опубликована: Апрель 15, 2016

Dietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results clinical studies patients with MetS involving chronic supplementation polyphenol-rich diet, foods, extracts or single phenolics features (obesity, dyslipidemia, blood pressure and glycaemia) associated complications (oxidative stress inflammation). Polyphenols were shown to be efficient, especially at higher doses, there no specific foods able alleviate all MetS. Green tea, however, significantly reduced body mass index waist circumference improved lipid metabolism. Cocoa glucose. Soy isoflavones, citrus products, hesperidin quercetin metabolism, whereas cinnamon In numerous studies, antioxidative anti-inflammatory effects not significant after polyphenol in However, some trials pointed towards an improvement endothelial function supplemented cocoa, anthocyanin-rich berries, resveratrol. Therefore, diets rich polyphenols, such as Mediterranean which promote consumption diverse products could effective nutritional strategy improve health © 2016 The Authors. Obesity Reviews published by John Wiley & Sons Ltd behalf World Obesity.

Язык: Английский

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The safety of green tea and green tea extract consumption in adults – Results of a systematic review

Regulatory Toxicology and Pharmacology, Год журнала: 2018, Номер 95, С. 412 - 433

Опубликована: Март 24, 2018

A systematic review of published toxicology and human intervention studies was performed to characterize potential hazards associated with consumption green tea its preparations. toxicological evidence from laboratory revealed the liver as target organ hepatotoxicity critical effect, which strongly certain dosing conditions (e.g. bolus dose via gavage, fasting), positively correlated total catechin epigallocatechingallate (EGCG) content. adverse event (AE) data 159 yielded findings consistent in that a limited range concentrated, catechin-rich preparations resulted hepatic AEs dose-dependent manner when ingested large doses, but not consumed brewed or extracts beverages part food. Toxico- pharmacokinetic further suggests internal catechins is key determinant occurrence severity hepatotoxicity. safe intake level 338 mg EGCG/day for adults derived safety solid dose. An Observed Safe Level (OSL) 704 might be considered beverage form based on AE data.

Язык: Английский

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Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health

Circulation Research, Год журнала: 2018, Номер 122(2), С. 369 - 384

Опубликована: Янв. 18, 2018

A growing body of nutritional science highlights the complex mechanisms and pleiotropic pathways cardiometabolic effects different foods. Among these, some most exciting advances are occurring in area flavonoids, bioactive phytochemicals found plant foods; dairy, including milk, yogurt, cheese. Many relevant ingredients mechanistic now being clarified, shedding new light on both for how diet influences health well-being. Flavonoids, example, have skeletal muscle, adipocytes, liver, pancreas, myocardial, renal, immune cells, instance, related to 5′-monophosphate-activated protein kinase phosphorylation, endothelial NO synthase activation, suppression NF-κB (nuclear factor-κB) TLR4 (toll-like receptor 4). Effects dairy similarly may be mediated by specific amino acids, medium-chain odd-chain saturated fats, unsaturated branched-chain natural trans probiotics, vitamin K1/K2, calcium, as well processing such fermentation homogenization. These characteristics foods influence diverse mammalian target rapamycin, silent information regulator transcript-1, angiotensin-converting enzyme, peroxisome proliferator–activated receptors, osteocalcin, matrix glutamate protein, hepatic de novo lipogenesis, adipose fatty acid oxidation inflammation, gut microbiome interactions intestinal integrity endotoxemia. The complexity these emerging corresponding biological responses rapid continued need generate robust empirical evidence clinical

Язык: Английский

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Role of oxidative stress and antioxidants in daily nutrition and human health

Nutrition, Год журнала: 2016, Номер 33, С. 311 - 321

Опубликована: Авг. 8, 2016

Язык: Английский

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Polyphenol protection and treatment of hypertension

Phytomedicine, Год журнала: 2016, Номер 23(2), С. 220 - 231

Опубликована: Янв. 7, 2016

Язык: Английский

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The beneficial therapeutic effects of plant‐derived natural products for the treatment of sarcopenia

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2022, Номер 13(6), С. 2772 - 2790

Опубликована: Авг. 12, 2022

Abstract Sarcopenia is an age‐related muscle disorder typically associated with a poor quality of life. Its definition has evolved over time, and several underlying causes sarcopenia in the elderly have been proposed. However, exact mechanisms involved sarcopenia, as well effective treatments for this condition, are not fully understood. The purpose article was to conduct comprehensive review previous evidence regarding definition, diagnosis, risk factors, efficacy plant‐derived natural products sarcopenia. methodological approach current narrative performed using PubMed, Scopus, Web Science databases, Google Scholar (up March 2021) order satisfy our objectives. substantial beneficial effects along safety some including curcumin, resveratrol, catechin, soy protein, ginseng on reported review. Based clinical studies, nutraceuticals functional foods may physical performance, handgrip knee‐extension strength, weight‐lifting capacity, time or distance travelled before feeling fatigued, mitochondrial function, fatigue, mean fibre area, total number myonuclei. In preclinical supplementation herbs bioactive compounds resulted increased plantaris mass, skeletal mass strength production, expression anabolic factors myogenin, Myf5 MyoD, enhanced inhibition atrophy We found that such nutritional status, inactivity, inflammation, oxidative stress, endocrine system dysfunction, insulin resistance, history chronic disease, mental health, genetic linked ginseng, without any significant side effects, Plant‐derived might effect various components Nevertheless, due limited human trials, benefits remain inconclusive. It suggested longitudinal studies better understand identifying treatment strategy based its pathophysiology, be undertaken future investigations.

Язык: Английский

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Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

Molecules, Год журнала: 2023, Номер 28(13), С. 5246 - 5246

Опубликована: Июль 6, 2023

Cellular signaling pathways involved in the maintenance of equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited prevention treatment cancer. Epigallocatechin-3-gallate (EGCG) is most abundant phenolic compound found green tea. It has been shown to regulate multiple crucial cellular pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, others. Deregulation abovementioned pathophysiology demonstrated EGCG may exert anti-proliferative, anti-inflammatory, apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical clinical studies suggest used numerous disorders, This review aims summarize existing knowledge regarding biological properties EGCG, especially context cancer prophylaxis.

Язык: Английский

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Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Molecules, Год журнала: 2024, Номер 29(6), С. 1373 - 1373

Опубликована: Март 20, 2024

Epigallocatechin gallate (EGCG) is a catechin, which type of flavonoid found in high concentrations green tea. EGCG has been studied extensively for its potential health benefits, particularly cancer. to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects numerous cancer cell lines animal models. demonstrated the ability interrupt various signaling pathways associated with cellular proliferation division different types. anticancer activity mediated by interfering hallmarks. This article summarize highlight on hallmarks focused impacts these cancer-related The studies discussed this review enrich understanding EGCG’s as therapeutic tool against cancer, offering substantial foundation scientists medical experts advance scientific clinical investigations regarding possibility treatment.

Язык: Английский

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