Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

ABSTRACT This study explores the effects of a nutraceutical blend with prebiotics, β‐glucans, essential minerals, and silymarin on gut microbiota, inflammation, sleep quality in obesity through microbiota reshaping metabolic improvements over 90 days. A double‐blind, randomized trial was conducted 77 participants divided into two groups receiving either standard (NSupple) or silymarin‐enriched (NSupple_ Silybum ). Fecal plasma samples were collected at baseline post‐supplementation for metabolic, inflammatory marker analysis. The results showed reduction body weight, waist‐to‐height ratio, total cholesterol, fractions NSupple_ group. There dysbiosis recovery shown by increase beneficial bacteria, such as Lentisphaerae phylum, Lactobacillus Faecalibacterium genera, prausnitzii NSupple group, concurrent Adlercreutzia Sutterella Both demonstrated improved profiles reduced TNF‐α/IL‐10 cortisol levels, Firmicutes/Bacteroides ratio. Additionally, associated reductions pro‐inflammatory cytokines composition. reshaped enhanced anti‐inflammatory species, parameters, highlighting its potential nutritional strategy managing reducing inflammation.

Язык: Английский

Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 1, 2025

Bioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked obesity. Compounds such berberine coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome exerting antioxidant effects, while beet pulp, rich fiber antioxidants, enhances health through additional prebiotic benefits. This study evaluated the effects of a nutraceutical supplement, Slim, on modulation obese mice induced by high-fat diet. Our results demonstrated that Slim supplementation significantly improved lipid metabolism, reshaped colon histomorphology, decreased levels Mucispirillum schaedleri, which were correlated with VLDL-c triglycerides. We suggest these driven duplibiotic effect, resulting from synergistic action bioactive compounds.

Язык: Английский

Personalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR

Clinics, Год журнала: 2024, Номер 80, С. 100549 - 100549

Опубликована: Дек. 5, 2024

Язык: Английский