Pathogens, Год журнала: 2023, Номер 12(10), С. 1253 - 1253
Опубликована: Окт. 18, 2023
Severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) emerged in a live animal market the Hubei Province of Wuhan China late 2019 and was declared pandemic by World Health Organization (WHO) on 11 March 2020 [...].
Язык: Английский
REVISTA BIOMÉDICA, Год журнала: 2024, Номер 35(2), С. 51 - 58
Опубликована: Апрель 22, 2024
Background: COVID-19, whose etiologic agent is SARS-CoV-2, an RNA virus, characterized by a high mutation rate. Therefore, while more subjects are infected, greater probability that the virus will potentially undergo changes confer evolutionary advantages (immune response evasion, increased virulence, and reduced vaccination efficacy). Efforts to acquire herd immunity through may be compromised in low- middle-income countries, where process slow inequitable. This lead new variant outbreaks with transmission capacity. it important surveillance circulating variants populations. Methods: In this sense, Tepic, Nayarit, Mexico, 100 viral genomes of positive patients were sequenced during beginning end third (August 4th September 3rd, 2021) fourth (January February 2nd, 2022) COVID-19 waves. Results: Sequence analysis revealed presence several variants; alpha (B.1.1.7), gamma (P.1), local (B.1.1.519), mu (B.1.621), delta (B.1.617.2), its subtypes (AY.3, AY.4, AY.10, AY.11, AY.20, AY.23.1) wave. Later, wave, still detected (AY.26 AY.113), as well omicron (B.1.1.529) (B.A.1 BA.1.1). Conclusion: Obtained data progressive shift dominant variants, delta, wave
Язык: Английский
Процитировано
0
Biotechnology Reports, Год журнала: 2024, Номер 45, С. e00869 - e00869
Опубликована: Дек. 7, 2024
Extracellular triacylglycerol hydrolases (ETH) play a critical role for microorganisms, acting as essential tools lipid breakdown and survival in challenging environments. The pursuit of more effective ETH genes enzymes through evolution holds significant potential enhancing living conditions. This study employs proteogenomic approach to identify high G+C notable Gram-positive bacterium,
Язык: Английский
Процитировано
0
Опубликована: Авг. 22, 2023
Worldwide, the COVID-19 pandemic, which was brought on by brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. Despite urgency, does not have any particular antiviral treatments at this time. As result, scientists are concentrating repurposing already existing medications or creating ones. The SARS-CoV-2 main protease, is necessary for viral replication, been identified as possible target family medicines called protease inhibitors (MPIs). Studies major proteases from SARS-CoV and MERS-CoV, remarkably similar structures functions to provided insight creation MPIs. By analyzing MPI trials review sheds light therapeutic uses MPIs COVID-19. talks about how work, effective they against safe are. paper also emphasizes current developments in including computational studies, vitro vivo research, clinical trials. According review, there lot hope treatment COVID-19, numerous works. Although more research needed assess their safety effectiveness settings, these may offer patients with much-needed option. importance ongoing into structure function information will be critical development other drugs future.
Язык: Английский
Процитировано
1
Pathogens, Год журнала: 2023, Номер 12(10), С. 1253 - 1253
Опубликована: Окт. 18, 2023
Severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) emerged in a live animal market the Hubei Province of Wuhan China late 2019 and was declared pandemic by World Health Organization (WHO) on 11 March 2020 [...].
Язык: Английский
Процитировано
0